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Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease.
J Endocrinol Invest. 1986 Dec; 9(6):479-86.JE

Abstract

Basal T4, T3, TSH, prolactin and growth hormone levels were determined in several groups: patients with postnecrotic cirrhosis with hepatocellular carcinoma (n = 14); patients with postnecrotic cirrhosis but without hepatocellular carcinoma (n = 26); cholangiolar carcinoma (n = 9); and normal controls age-matched to within 5 yr of the liver disease subjects studied. In addition, TRH stimulation (400 micrograms TRH) was performed; TSH, prolactin and growth hormone responses over a 180-min time interval were evaluated for each subject. The responses observed varied between liver disease groups. The presence or absence of hepatocellular carcinoma was found to determine, at least in part, the type of response observed. Similarly, the presence or absence of hepatic encephalopathy determined, and/or reflected, at least in part, the type of response observed. Finally, for purposes of continuity, basal and TRH-stimulated levels of TSH, prolactin, growth hormone, T4 and T3 are compared in 3 settings of cirrhosis: alcoholic, nonalcoholic postnecrotic cirrhosis, and postnecrotic cirrhosis with hepatocellular carcinoma.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3033051

Citation

Van Thiel, D H., et al. "Thyroid and Pituitary Hormone Responses to TRH in Advanced Nonalcoholic Liver Disease." Journal of Endocrinological Investigation, vol. 9, no. 6, 1986, pp. 479-86.
Van Thiel DH, Tarter R, Gavaler JS, et al. Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. J Endocrinol Invest. 1986;9(6):479-86.
Van Thiel, D. H., Tarter, R., Gavaler, J. S., Schade, R. R., & Sanghvi, A. (1986). Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. Journal of Endocrinological Investigation, 9(6), 479-86.
Van Thiel DH, et al. Thyroid and Pituitary Hormone Responses to TRH in Advanced Nonalcoholic Liver Disease. J Endocrinol Invest. 1986;9(6):479-86. PubMed PMID: 3033051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. AU - Van Thiel,D H, AU - Tarter,R, AU - Gavaler,J S, AU - Schade,R R, AU - Sanghvi,A, PY - 1986/12/1/pubmed PY - 1986/12/1/medline PY - 1986/12/1/entrez SP - 479 EP - 86 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 9 IS - 6 N2 - Basal T4, T3, TSH, prolactin and growth hormone levels were determined in several groups: patients with postnecrotic cirrhosis with hepatocellular carcinoma (n = 14); patients with postnecrotic cirrhosis but without hepatocellular carcinoma (n = 26); cholangiolar carcinoma (n = 9); and normal controls age-matched to within 5 yr of the liver disease subjects studied. In addition, TRH stimulation (400 micrograms TRH) was performed; TSH, prolactin and growth hormone responses over a 180-min time interval were evaluated for each subject. The responses observed varied between liver disease groups. The presence or absence of hepatocellular carcinoma was found to determine, at least in part, the type of response observed. Similarly, the presence or absence of hepatic encephalopathy determined, and/or reflected, at least in part, the type of response observed. Finally, for purposes of continuity, basal and TRH-stimulated levels of TSH, prolactin, growth hormone, T4 and T3 are compared in 3 settings of cirrhosis: alcoholic, nonalcoholic postnecrotic cirrhosis, and postnecrotic cirrhosis with hepatocellular carcinoma. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/3033051/Thyroid_and_pituitary_hormone_responses_to_TRH_in_advanced_nonalcoholic_liver_disease_ L2 - https://link.springer.com/article/10.1007/BF03346970 DB - PRIME DP - Unbound Medicine ER -