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Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl).
Nat Prod Res. 2020 Jun; 34(11):1621-1625.NP

Abstract

The flavonoid compositions, extracted from leaves, peel and flesh of white guava (Psidium guajava L. cv. Pearl), were identified and quantified by UPLC-ESI-QTOF-MS, HPLC-ESI-MS/MS and HPLC. The main components of three extracts all were quercetin-glycosides, but the proportion and content of quercetin-hexoside and quercetin-pentoside in each extract were different. Based on the measurements of MIC, MBC value and time killing curve, it emerged that 3 flavonoid extracts of white guava had good antibacterial effects on four pathogenic bacteria. White guava leaves flavonoids (WGLF) concentrations of 5.00 mg/mL and 0.625 mg/mL could change the micro-morphology of Escherichia coli and Staphylococcus aureus. It suggested that the antibacterial mechanism of WGLF on gram-positive and gram-negative bacteria was to destroy the structure and function of the cell membrane. It is indicated that the flavonoid extracts from white guava is a potential natural antimicrobial agent.

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Authors+Show Affiliations

Natural Product Laboratory Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Natural Product Laboratory Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Natural Product Laboratory Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Natural Product Laboratory Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Natural Product Laboratory Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Natural Product Laboratory Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

MeSH

Anti-Bacterial AgentsCell MembraneChromatography, High Pressure LiquidEscherichia coliFlavonoidsGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsPlant ExtractsPlant LeavesPsidiumQuercetinSpectrometry, Mass, Electrospray IonizationStaphylococcus aureusTandem Mass Spectrometry

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30334458

Citation

Zhang, Wanjun, et al. "Flavonoid Compounds and Antibacterial Mechanisms of Different Parts of White Guava (Psidium Guajava L. Cv. Pearl)." Natural Product Research, vol. 34, no. 11, 2020, pp. 1621-1625.

Zhang W, Wang J, Chen Y, et al. Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl). Nat Prod Res. 2020;34(11):1621-1625.

Zhang, W., Wang, J., Chen, Y., Zheng, H., Xie, B., & Sun, Z. (2020). Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl). Natural Product Research, 34(11), 1621-1625. https://doi.org/10.1080/14786419.2018.1522313

Zhang W, et al. Flavonoid Compounds and Antibacterial Mechanisms of Different Parts of White Guava (Psidium Guajava L. Cv. Pearl). Nat Prod Res. 2020;34(11):1621-1625. PubMed PMID: 30334458.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl). AU - Zhang,Wanjun, AU - Wang,Jingyi, AU - Chen,Yashu, AU - Zheng,Hongbin, AU - Xie,Bijun, AU - Sun,Zhida, Y1 - 2018/10/18/ PY - 2018/10/20/pubmed PY - 2020/8/4/medline PY - 2018/10/19/entrez KW - HPLC-ESI-MS/MS KW - Psidium guajava L. KW - UPLC-ESI-QTOF-MS KW - antibacterial activity KW - antibacterial mechanism KW - flavonoid compounds SP - 1621 EP - 1625 JF - Natural product research JO - Nat Prod Res VL - 34 IS - 11 N2 - The flavonoid compositions, extracted from leaves, peel and flesh of white guava (Psidium guajava L. cv. Pearl), were identified and quantified by UPLC-ESI-QTOF-MS, HPLC-ESI-MS/MS and HPLC. The main components of three extracts all were quercetin-glycosides, but the proportion and content of quercetin-hexoside and quercetin-pentoside in each extract were different. Based on the measurements of MIC, MBC value and time killing curve, it emerged that 3 flavonoid extracts of white guava had good antibacterial effects on four pathogenic bacteria. White guava leaves flavonoids (WGLF) concentrations of 5.00 mg/mL and 0.625 mg/mL could change the micro-morphology of Escherichia coli and Staphylococcus aureus. It suggested that the antibacterial mechanism of WGLF on gram-positive and gram-negative bacteria was to destroy the structure and function of the cell membrane. It is indicated that the flavonoid extracts from white guava is a potential natural antimicrobial agent. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/30334458/Flavonoid_compounds_and_antibacterial_mechanisms_of_different_parts_of_white_guava__Psidium_guajava_L__cv__Pearl__ DB - PRIME DP - Unbound Medicine ER -