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Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone.
Org Lett. 2018 10 19; 20(20):6440-6443.OL

Abstract

The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. The reaction provides an innovative synthetic approach for indoles. The approach features high efficiency, broad substrate scope, and excellent regioselectivity. C, C-Palladacycles should act as the intermediates. The C, C-palladacycles are obtained from simple aryl halides and alkynes and then reacted with diaziridinone to afford indoles.

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Authors+Show Affiliations

School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability , Tongji University , 1239 Siping Road , Shanghai , 200092 , P. R. China.

School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability , Tongji University , 1239 Siping Road , Shanghai , 200092 , P. R. China.

School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability , Tongji University , 1239 Siping Road , Shanghai , 200092 , P. R. China.

School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability , Tongji University , 1239 Siping Road , Shanghai , 200092 , P. R. China.

School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability , Tongji University , 1239 Siping Road , Shanghai , 200092 , P. R. China.

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30336674

Citation

Zhou, Bo, et al. "Synthesis of Indoles Through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone." Organic Letters, vol. 20, no. 20, 2018, pp. 6440-6443.

Zhou B, Wu Z, Ma D, et al. Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone. Org Lett. 2018;20(20):6440-6443.

Zhou, B., Wu, Z., Ma, D., Ji, X., & Zhang, Y. (2018). Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone. Organic Letters, 20(20), 6440-6443. https://doi.org/10.1021/acs.orglett.8b02750

Zhou B, et al. Synthesis of Indoles Through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone. Org Lett. 2018 10 19;20(20):6440-6443. PubMed PMID: 30336674.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone. AU - Zhou,Bo, AU - Wu,Zhuo, AU - Ma,Ding, AU - Ji,Xiaoming, AU - Zhang,Yanghui, Y1 - 2018/10/10/ PY - 2018/10/20/entrez PY - 2018/10/20/pubmed PY - 2018/10/20/medline SP - 6440 EP - 6443 JF - Organic letters JO - Org Lett VL - 20 IS - 20 N2 - The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. The reaction provides an innovative synthetic approach for indoles. The approach features high efficiency, broad substrate scope, and excellent regioselectivity. C, C-Palladacycles should act as the intermediates. The C, C-palladacycles are obtained from simple aryl halides and alkynes and then reacted with diaziridinone to afford indoles. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/30336674/Synthesis_of_Indoles_through_Palladium_Catalyzed_Three_Component_Reaction_of_Aryl_Iodides_Alkynes_and_Diaziridinone_ DB - PRIME DP - Unbound Medicine ER -