Tags

Type your tag names separated by a space and hit enter

The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature.
Prostaglandins Leukot Med. 1987 Mar; 26(3):253-63.PL

Abstract

The interactions of n-6 and n-3 fatty acids on prostaglandin metabolism in the isolated rat mesenteric vessels were studied. Sprague-Dawley rats (200-220 g) were fed for two weeks a fat-free semi-synthetic diet supplemented with 10% by weight of different combinations of Evening Primrose Oil (Efamol), a rich source of linoleic acid (LA) and gamma-linolenic acid (GLA), the immediate precursor of dihomo-gamma-linolenic acid (DGLA), and Polepa (POL), a marine oil rich in eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. The combinations of supplement were as follows: 9% Efamol - 1% POL, 8% Efamol - 2% POL, 7% Efamol - 3% POL, 6% Efamol - 4% POL, 5% Efamol - 5% POL. The outflow of thromboxane (TxB2), prostacyclin (6-keto-PGF1 alpha), PGE2, and PGE1 was decreased in relation to the proportion of marine oil in the diet, except for the group which received 8% Efamol - 2% POL, and which showed an increase in 6-keto-PGF1 alpha, PGE2, and PGE1. The decrease in TxB2 was much greater than those of 6-keto-PGF1 alpha or PGE2, while PGE1 followed the same pattern as prostacyclin and PGE2. These results suggest that n-3 fatty acids, at high concentrations, inhibits conversion of both DGLA and AA to eicosanoids. Low concentrations of fish oil may, in contrast, increase formation of desirable 1 and 2 series eicosanoids.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3033691

Citation

Nassar, B A., et al. "The Influence of Dietary Marine Oil (Polepa) and Evening Primrose Oil (Efamol) On Prostaglandin Production By the Rat Mesenteric Vasculature." Prostaglandins, Leukotrienes, and Medicine, vol. 26, no. 3, 1987, pp. 253-63.
Nassar BA, Manku MS, Huang YS, et al. The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. Prostaglandins Leukot Med. 1987;26(3):253-63.
Nassar, B. A., Manku, M. S., Huang, Y. S., Jenkins, D. K., & Horrobin, D. F. (1987). The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. Prostaglandins, Leukotrienes, and Medicine, 26(3), 253-63.
Nassar BA, et al. The Influence of Dietary Marine Oil (Polepa) and Evening Primrose Oil (Efamol) On Prostaglandin Production By the Rat Mesenteric Vasculature. Prostaglandins Leukot Med. 1987;26(3):253-63. PubMed PMID: 3033691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. AU - Nassar,B A, AU - Manku,M S, AU - Huang,Y S, AU - Jenkins,D K, AU - Horrobin,D F, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 253 EP - 63 JF - Prostaglandins, leukotrienes, and medicine JO - Prostaglandins Leukot Med VL - 26 IS - 3 N2 - The interactions of n-6 and n-3 fatty acids on prostaglandin metabolism in the isolated rat mesenteric vessels were studied. Sprague-Dawley rats (200-220 g) were fed for two weeks a fat-free semi-synthetic diet supplemented with 10% by weight of different combinations of Evening Primrose Oil (Efamol), a rich source of linoleic acid (LA) and gamma-linolenic acid (GLA), the immediate precursor of dihomo-gamma-linolenic acid (DGLA), and Polepa (POL), a marine oil rich in eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. The combinations of supplement were as follows: 9% Efamol - 1% POL, 8% Efamol - 2% POL, 7% Efamol - 3% POL, 6% Efamol - 4% POL, 5% Efamol - 5% POL. The outflow of thromboxane (TxB2), prostacyclin (6-keto-PGF1 alpha), PGE2, and PGE1 was decreased in relation to the proportion of marine oil in the diet, except for the group which received 8% Efamol - 2% POL, and which showed an increase in 6-keto-PGF1 alpha, PGE2, and PGE1. The decrease in TxB2 was much greater than those of 6-keto-PGF1 alpha or PGE2, while PGE1 followed the same pattern as prostacyclin and PGE2. These results suggest that n-3 fatty acids, at high concentrations, inhibits conversion of both DGLA and AA to eicosanoids. Low concentrations of fish oil may, in contrast, increase formation of desirable 1 and 2 series eicosanoids. SN - 0262-1746 UR - https://www.unboundmedicine.com/medline/citation/3033691/The_influence_of_dietary_marine_oil__Polepa__and_evening_primrose_oil__Efamol__on_prostaglandin_production_by_the_rat_mesenteric_vasculature_ L2 - https://antibodies.cancer.gov/detail/CPTC-TIMP1-2 DB - PRIME DP - Unbound Medicine ER -