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Gas Signaling Molecules and Mitochondrial Potassium Channels.
Int J Mol Sci. 2018 Oct 18; 19(10)IJ

Abstract

Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H₂S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low concentrations. These so-called gasotransmitters affect many cellular processes, such as apoptosis, proliferation, cytoprotection, oxygen sensing, ATP synthesis, and cellular respiration. It is thought that mitochondria, specifically their respiratory complexes, constitute an important target for these gases. On the other hand, increasing evidence of a cytoprotective role for mitochondrial potassium channels provides motivation for the analysis of the role of gasotransmitters in the regulation of channel function. A number of potassium channels have been shown to exhibit activity within the inner mitochondrial membrane, including ATP-sensitive potassium channels, Ca2+-activated potassium channels, voltage-gated Kv potassium channels, and TWIK-related acid-sensitive K⁺ channel 3 (TASK-3). The effects of these channels include the regulation of mitochondrial respiration and membrane potential. Additionally, they may modulate the synthesis of reactive oxygen species within mitochondria. The opening of mitochondrial potassium channels is believed to induce cytoprotection, while channel inhibition may facilitate cell death. The molecular mechanisms underlying the action of gasotransmitters are complex. In this review, we focus on the molecular mechanisms underlying the action of H₂S, NO, and CO on potassium channels present within mitochondria.

Authors+Show Affiliations

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology PAS, 3 Pasteur St., 02-093 Warsaw, Poland. a.walewska@nencki.gov.pl.Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology PAS, 3 Pasteur St., 02-093 Warsaw, Poland. a.szewczyk@nencki.gov.pl.Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology PAS, 3 Pasteur St., 02-093 Warsaw, Poland. p.koprowski@nencki.gov.pl.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30340432

Citation

Walewska, Agnieszka, et al. "Gas Signaling Molecules and Mitochondrial Potassium Channels." International Journal of Molecular Sciences, vol. 19, no. 10, 2018.
Walewska A, Szewczyk A, Koprowski P. Gas Signaling Molecules and Mitochondrial Potassium Channels. Int J Mol Sci. 2018;19(10).
Walewska, A., Szewczyk, A., & Koprowski, P. (2018). Gas Signaling Molecules and Mitochondrial Potassium Channels. International Journal of Molecular Sciences, 19(10). https://doi.org/10.3390/ijms19103227
Walewska A, Szewczyk A, Koprowski P. Gas Signaling Molecules and Mitochondrial Potassium Channels. Int J Mol Sci. 2018 Oct 18;19(10) PubMed PMID: 30340432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gas Signaling Molecules and Mitochondrial Potassium Channels. AU - Walewska,Agnieszka, AU - Szewczyk,Adam, AU - Koprowski,Piotr, Y1 - 2018/10/18/ PY - 2018/09/28/received PY - 2018/10/15/revised PY - 2018/10/16/accepted PY - 2018/10/21/entrez PY - 2018/10/21/pubmed PY - 2019/1/24/medline KW - BKCa channel KW - KATP channel KW - carbon monoxide KW - gasotransmitters KW - heme KW - hydrogen sulfide KW - mitochondria KW - nitric oxide KW - potassium channels JF - International journal of molecular sciences JO - Int J Mol Sci VL - 19 IS - 10 N2 - Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H₂S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low concentrations. These so-called gasotransmitters affect many cellular processes, such as apoptosis, proliferation, cytoprotection, oxygen sensing, ATP synthesis, and cellular respiration. It is thought that mitochondria, specifically their respiratory complexes, constitute an important target for these gases. On the other hand, increasing evidence of a cytoprotective role for mitochondrial potassium channels provides motivation for the analysis of the role of gasotransmitters in the regulation of channel function. A number of potassium channels have been shown to exhibit activity within the inner mitochondrial membrane, including ATP-sensitive potassium channels, Ca2+-activated potassium channels, voltage-gated Kv potassium channels, and TWIK-related acid-sensitive K⁺ channel 3 (TASK-3). The effects of these channels include the regulation of mitochondrial respiration and membrane potential. Additionally, they may modulate the synthesis of reactive oxygen species within mitochondria. The opening of mitochondrial potassium channels is believed to induce cytoprotection, while channel inhibition may facilitate cell death. The molecular mechanisms underlying the action of gasotransmitters are complex. In this review, we focus on the molecular mechanisms underlying the action of H₂S, NO, and CO on potassium channels present within mitochondria. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/30340432/Gas_Signaling_Molecules_and_Mitochondrial_Potassium_Channels_ L2 - https://www.mdpi.com/resolver?pii=ijms19103227 DB - PRIME DP - Unbound Medicine ER -