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Phytates and the inhibitory effect of bran on iron absorption in man.
Am J Clin Nutr. 1987 May; 45(5):988-96.AJ

Abstract

The cause of marked inhibitory effect of bran on absorption of dietary nonheme iron was studied in man by double-radioiron technique. Washing bran with hydrochloric acid but not with water removed inhibitory factor(s). Inhibition was almost restored by reconstituting phytate level. Removal of phytates in bran by endogenous phytase significantly increased absorption of iron. Removing, by washing with water, phosphates formed from phytates during enzymatic dephytinization led to a bran fraction with only a small remaining inhibitory effect on iron absorption. Half the iron in bran is in the form of monoferric phytate, which is well-absorbed. When potassium and magnesium phytates were added in amounts present in bran, the same inhibitory effect on iron absorption was seen. Although there appear to be other factors in bran that partly explain the inhibition, phytates are the main cause of the inhibitory effect of bran on iron absorption.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3034044

Citation

Hallberg, L, et al. "Phytates and the Inhibitory Effect of Bran On Iron Absorption in Man." The American Journal of Clinical Nutrition, vol. 45, no. 5, 1987, pp. 988-96.
Hallberg L, Rossander L, Skånberg AB. Phytates and the inhibitory effect of bran on iron absorption in man. Am J Clin Nutr. 1987;45(5):988-96.
Hallberg, L., Rossander, L., & Skånberg, A. B. (1987). Phytates and the inhibitory effect of bran on iron absorption in man. The American Journal of Clinical Nutrition, 45(5), 988-96.
Hallberg L, Rossander L, Skånberg AB. Phytates and the Inhibitory Effect of Bran On Iron Absorption in Man. Am J Clin Nutr. 1987;45(5):988-96. PubMed PMID: 3034044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytates and the inhibitory effect of bran on iron absorption in man. AU - Hallberg,L, AU - Rossander,L, AU - Skånberg,A B, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 988 EP - 96 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 45 IS - 5 N2 - The cause of marked inhibitory effect of bran on absorption of dietary nonheme iron was studied in man by double-radioiron technique. Washing bran with hydrochloric acid but not with water removed inhibitory factor(s). Inhibition was almost restored by reconstituting phytate level. Removal of phytates in bran by endogenous phytase significantly increased absorption of iron. Removing, by washing with water, phosphates formed from phytates during enzymatic dephytinization led to a bran fraction with only a small remaining inhibitory effect on iron absorption. Half the iron in bran is in the form of monoferric phytate, which is well-absorbed. When potassium and magnesium phytates were added in amounts present in bran, the same inhibitory effect on iron absorption was seen. Although there appear to be other factors in bran that partly explain the inhibition, phytates are the main cause of the inhibitory effect of bran on iron absorption. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/3034044/Phytates_and_the_inhibitory_effect_of_bran_on_iron_absorption_in_man_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/45.5.988 DB - PRIME DP - Unbound Medicine ER -