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Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial.
Breast Cancer Res 2018; 20(1):124BC

Abstract

BACKGROUND

Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors.

METHODS

One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis.

RESULTS

At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO2max (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01).

CONCLUSIONS

A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care.

TRIAL REGISTRATION

This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.

Authors+Show Affiliations

Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA. cdieli@usc.edu. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. cdieli@usc.edu.Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.Division of Endocrinology and Diabetes, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.Division of Biomarkers of Early Detection and Prevention, Beckman Research Institute, City of Hope (COH), Duarte, CA, 91010, USA.Division of Medical Oncology and Experimental Therapeutics, COH, Duarte, CA, 91010, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

30340503

Citation

Dieli-Conwright, Christina M., et al. "Aerobic and Resistance Exercise Improves Physical Fitness, Bone Health, and Quality of Life in Overweight and Obese Breast Cancer Survivors: a Randomized Controlled Trial." Breast Cancer Research : BCR, vol. 20, no. 1, 2018, p. 124.
Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, et al. Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial. Breast Cancer Res. 2018;20(1):124.
Dieli-Conwright, C. M., Courneya, K. S., Demark-Wahnefried, W., Sami, N., Lee, K., Sweeney, F. C., ... Mortimer, J. E. (2018). Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial. Breast Cancer Research : BCR, 20(1), p. 124. doi:10.1186/s13058-018-1051-6.
Dieli-Conwright CM, et al. Aerobic and Resistance Exercise Improves Physical Fitness, Bone Health, and Quality of Life in Overweight and Obese Breast Cancer Survivors: a Randomized Controlled Trial. Breast Cancer Res. 2018 10 19;20(1):124. PubMed PMID: 30340503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial. AU - Dieli-Conwright,Christina M, AU - Courneya,Kerry S, AU - Demark-Wahnefried,Wendy, AU - Sami,Nathalie, AU - Lee,Kyuwan, AU - Sweeney,Frank C, AU - Stewart,Christina, AU - Buchanan,Thomas A, AU - Spicer,Darcy, AU - Tripathy,Debu, AU - Bernstein,Leslie, AU - Mortimer,Joanne E, Y1 - 2018/10/19/ PY - 2018/07/26/received PY - 2018/09/13/accepted PY - 2018/10/21/entrez PY - 2018/10/21/pubmed PY - 2019/6/7/medline KW - Exercise KW - bone health KW - breast cancer KW - physical fitness KW - quality of life SP - 124 EP - 124 JF - Breast cancer research : BCR JO - Breast Cancer Res. VL - 20 IS - 1 N2 - BACKGROUND: Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors. METHODS: One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis. RESULTS: At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO2max (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01). CONCLUSIONS: A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care. TRIAL REGISTRATION: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. SN - 1465-542X UR - https://www.unboundmedicine.com/medline/citation/30340503/Aerobic_and_resistance_exercise_improves_physical_fitness_bone_health_and_quality_of_life_in_overweight_and_obese_breast_cancer_survivors:_a_randomized_controlled_trial_ L2 - https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1051-6 DB - PRIME DP - Unbound Medicine ER -