Tags

Type your tag names separated by a space and hit enter

Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats.
Curr Med Sci. 2018 Oct; 38(5):903-909.CM

Abstract

Paired associative stimulation (PAS), combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI) in between, has been shown to influence the excitability of the motor cortex (MC) in humans. However, the underlying mechanisms remain unclear. This study was designed to explore an optimal protocol of PAS, which can modulate the excitability of MC in rats, and to investigate the underlying mechanisms. The resting motor thresholds (RMTs) of TMS-elicited motor evoked potentials (MEPs) recorded from the gastrocnemius muscle and the latency of P1 component of somatosensory evoked potentials (SEPs) induced by electrical tibial nerve stimulation were determined in male Sprague-Dawley rats (n=10). Sixty rats were then randomly divided into 3 groups: a PAS group (further divided into 10 subgroups at various ISIs calculated by using the latency of P1, n=5, respectively), a TMS (only) group (n=5) and a PNS (only) group (n=5). Ninety repetitions of PAS, TMS and PNS were administered to the rats in the 3 groups, respectively, at the frequency of 0.05 Hz and the intensity of TMS at 120% RMT and that of PNS at 6 mA. RMTs and motor evoked potentials' amplitude (MEPamp) were recorded before and immediately after the interventions. It was found that the MEPamp significantly decreased after PAS at ISI of 5 ms (P<0.05), while the MEPamp significantly increased after PAS at ISI of 15 ms, as compared with those before the intervention (P<0.05). However, the RMT did not change significantly after PAS at ISI of 5 ms or 15 ms (P>0.05). PAS at other ISIs as well as the sole use of TMS and PNS induced no remarkable changes in MEPamp and RMT. In conclusion, PAS can influence motor cortex excitability in rats. Neither TMS alone nor PNS alone shows significant effect.

Authors+Show Affiliations

Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Department of Rehabilitation Medicine, the 5th Hospital of Zhengzhou University, Zhengzhou, 470000, China.Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Department of Rehabilitation Medicine, the 1st People's Hospital of Haikou, Haikou, 570208, China.Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. pmr@tjh.tjmu.edu.cn.Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Department of Rehabilitation Medicine, the 1st Hospital of Wuhan, Wuhan, 430022, China.Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Department of Rehabilitation Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30341527

Citation

Zhang, Xiang-Yu, et al. "Effect of Paired Associative Stimulation On Motor Cortex Excitability in Rats." Current Medical Science, vol. 38, no. 5, 2018, pp. 903-909.
Zhang XY, Sui YF, Guo TC, et al. Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats. Curr Med Sci. 2018;38(5):903-909.
Zhang, X. Y., Sui, Y. F., Guo, T. C., Wang, S. H., Hu, Y., & Lu, Y. S. (2018). Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats. Current Medical Science, 38(5), 903-909. https://doi.org/10.1007/s11596-018-1960-8
Zhang XY, et al. Effect of Paired Associative Stimulation On Motor Cortex Excitability in Rats. Curr Med Sci. 2018;38(5):903-909. PubMed PMID: 30341527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats. AU - Zhang,Xiang-Yu, AU - Sui,Yan-Fang, AU - Guo,Tie-Cheng, AU - Wang,Sai-Hua, AU - Hu,Yan, AU - Lu,Yin-Shan, Y1 - 2018/10/20/ PY - 2018/06/07/received PY - 2018/09/10/revised PY - 2018/10/21/entrez PY - 2018/10/21/pubmed PY - 2019/1/25/medline KW - electrical stimulation KW - motor evoked potentials KW - paired associative stimulation KW - peripheral nerves KW - resting motor thresholds KW - somatosensory evoked potentials KW - transcranial magnetic stimulation SP - 903 EP - 909 JF - Current medical science JO - Curr Med Sci VL - 38 IS - 5 N2 - Paired associative stimulation (PAS), combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI) in between, has been shown to influence the excitability of the motor cortex (MC) in humans. However, the underlying mechanisms remain unclear. This study was designed to explore an optimal protocol of PAS, which can modulate the excitability of MC in rats, and to investigate the underlying mechanisms. The resting motor thresholds (RMTs) of TMS-elicited motor evoked potentials (MEPs) recorded from the gastrocnemius muscle and the latency of P1 component of somatosensory evoked potentials (SEPs) induced by electrical tibial nerve stimulation were determined in male Sprague-Dawley rats (n=10). Sixty rats were then randomly divided into 3 groups: a PAS group (further divided into 10 subgroups at various ISIs calculated by using the latency of P1, n=5, respectively), a TMS (only) group (n=5) and a PNS (only) group (n=5). Ninety repetitions of PAS, TMS and PNS were administered to the rats in the 3 groups, respectively, at the frequency of 0.05 Hz and the intensity of TMS at 120% RMT and that of PNS at 6 mA. RMTs and motor evoked potentials' amplitude (MEPamp) were recorded before and immediately after the interventions. It was found that the MEPamp significantly decreased after PAS at ISI of 5 ms (P<0.05), while the MEPamp significantly increased after PAS at ISI of 15 ms, as compared with those before the intervention (P<0.05). However, the RMT did not change significantly after PAS at ISI of 5 ms or 15 ms (P>0.05). PAS at other ISIs as well as the sole use of TMS and PNS induced no remarkable changes in MEPamp and RMT. In conclusion, PAS can influence motor cortex excitability in rats. Neither TMS alone nor PNS alone shows significant effect. SN - 2523-899X UR - https://www.unboundmedicine.com/medline/citation/30341527/Effect_of_Paired_Associative_Stimulation_on_Motor_Cortex_Excitability_in_Rats_ L2 - https://doi.org/10.1007/s11596-018-1960-8 DB - PRIME DP - Unbound Medicine ER -