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The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers.
Psychoneuroendocrinology. 2019 02; 100:172-179.P

Abstract

The co-regulation of the hypothalamic-pituitary-adrenal (HPA) axis in mother-infant dyads is thought to be key for infant and child development. Nonetheless, previous literature presents some inconsistencies that might at least partially be due to the presence of risk conditions and the use of different statistical approaches to measure HPA axis co-regulation. Very preterm (VPT) birth represents one of these risk conditions as the early foundation of mother-infant interaction is disrupted. Both VPT infants and their mothers present evidence of altered HPA axis regulation. Nonetheless, the comparison of mother-infant HPA axis co-regulation in VPT infants compared to full-term (FT) ones has not been previously investigated. In this study, 3-month-old (corrected age) VPT infants and FT counterparts with their mothers took part in a well-validated stress-inducing laboratory task (i.e., double Face-to-Face Still-Face, FFSF paradigm). Salivary cortisol samples were obtained before (Baseline) and after (Early reactivity, Late reactivity and Recovery) the FFSF procedure. Dyadic HPA axis co-regulation was assessed at each sample time-point (i.e., in-moment coupling) as well as across samples (i.e., in-time synchrony). Significant in-moment coupling emerged at Baseline, Late reactivity and Recovery for FT infants' dyads only. An overlying pattern of salivary cortisol trajectories emerged between mothers and infants in the VPT group, whereas a more complex pattern of reciprocal and complementary co-regulation was found for FT infants' dyads. Although both groups gave evidence of HPA axis co-regulation, dyads of VPT infants appear to be less able to adapt reciprocally and dynamically to stressful conditions. These findings suggest that multiple approaches to account for dyadic HPA axis co-regulation should be used in order to depict the complex pattern of biological rhythms coordination in mother-infant dyads.

Authors+Show Affiliations

Scientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy.Scientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy.NICU, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy.Scientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy.Pediatric Unit, Sacra Famiglia Hospital Fatebenefratelli, Erba, CO, Italy.Neuropsychiatry and Neurorehabilitation Unit, Scientific Institute IRCCS Eugenio Medea, Lecco, Italy.NICU, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy.Scientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30343183

Citation

Provenzi, Livio, et al. "The Dual Nature of Hypothalamic-pituitary-adrenal Axis Regulation in Dyads of Very Preterm Infants and Their Mothers." Psychoneuroendocrinology, vol. 100, 2019, pp. 172-179.
Provenzi L, Giusti L, Fumagalli M, et al. The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers. Psychoneuroendocrinology. 2019;100:172-179.
Provenzi, L., Giusti, L., Fumagalli, M., Frigerio, S., Morandi, F., Borgatti, R., Mosca, F., & Montirosso, R. (2019). The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers. Psychoneuroendocrinology, 100, 172-179. https://doi.org/10.1016/j.psyneuen.2018.10.007
Provenzi L, et al. The Dual Nature of Hypothalamic-pituitary-adrenal Axis Regulation in Dyads of Very Preterm Infants and Their Mothers. Psychoneuroendocrinology. 2019;100:172-179. PubMed PMID: 30343183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers. AU - Provenzi,Livio, AU - Giusti,Lorenzo, AU - Fumagalli,Monica, AU - Frigerio,Susanna, AU - Morandi,Francesco, AU - Borgatti,Renato, AU - Mosca,Fabio, AU - Montirosso,Rosario, Y1 - 2018/10/12/ PY - 2018/07/16/received PY - 2018/10/11/revised PY - 2018/10/11/accepted PY - 2018/10/22/pubmed PY - 2020/3/25/medline PY - 2018/10/22/entrez KW - Cortisol KW - HPA axis KW - Mother-infant interaction KW - NICU KW - Preterm birth KW - Stress regulation SP - 172 EP - 179 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 100 N2 - The co-regulation of the hypothalamic-pituitary-adrenal (HPA) axis in mother-infant dyads is thought to be key for infant and child development. Nonetheless, previous literature presents some inconsistencies that might at least partially be due to the presence of risk conditions and the use of different statistical approaches to measure HPA axis co-regulation. Very preterm (VPT) birth represents one of these risk conditions as the early foundation of mother-infant interaction is disrupted. Both VPT infants and their mothers present evidence of altered HPA axis regulation. Nonetheless, the comparison of mother-infant HPA axis co-regulation in VPT infants compared to full-term (FT) ones has not been previously investigated. In this study, 3-month-old (corrected age) VPT infants and FT counterparts with their mothers took part in a well-validated stress-inducing laboratory task (i.e., double Face-to-Face Still-Face, FFSF paradigm). Salivary cortisol samples were obtained before (Baseline) and after (Early reactivity, Late reactivity and Recovery) the FFSF procedure. Dyadic HPA axis co-regulation was assessed at each sample time-point (i.e., in-moment coupling) as well as across samples (i.e., in-time synchrony). Significant in-moment coupling emerged at Baseline, Late reactivity and Recovery for FT infants' dyads only. An overlying pattern of salivary cortisol trajectories emerged between mothers and infants in the VPT group, whereas a more complex pattern of reciprocal and complementary co-regulation was found for FT infants' dyads. Although both groups gave evidence of HPA axis co-regulation, dyads of VPT infants appear to be less able to adapt reciprocally and dynamically to stressful conditions. These findings suggest that multiple approaches to account for dyadic HPA axis co-regulation should be used in order to depict the complex pattern of biological rhythms coordination in mother-infant dyads. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/30343183/The_dual_nature_of_hypothalamic_pituitary_adrenal_axis_regulation_in_dyads_of_very_preterm_infants_and_their_mothers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(18)30719-4 DB - PRIME DP - Unbound Medicine ER -