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Correlation of liver function with intestinal flora, vitamin deficiency and IL-17A in patients with liver cirrhosis.
Exp Ther Med 2018; 16(5):4082-4088ET

Abstract

The aim of this study was to investigate the correlation of liver function, intestinal flora, vitamin D and interleukin-17A (IL-17A) levels in patients with liver cirrhosis. A total of 52 patients diagnosed with posthepatitic cirrhosis and admitted into Yantai Infectious Disease Hospital (Yantai, China) from January to December in 2012 (liver cirrhosis group), and 52 patients with chronic hepatitis B (hepatitis group), and 40 healthy volunteers receiving physical examination in the hospital (normal control group) were selected into the study. The liver function, hepatitis B virus (HBV) deoxyribonucleic acid (DNA) level, intestinal flora distribution, vitamin D and IL-17A levels of all patients were detected, and the correlation among them was analyzed via Pearson's analysis. The number of Enterobacteriaceae, Enterococcus, Staphylococcus aureus and Saccharomyces in hepatitis and liver cirrhosis groups was significantly greater than in the normal control group (P<0.05), but the number of Lactobacillus, Bacteroides, Bifidobacterium and Clostridium was significantly decreased (P<0.05); the serum IL-17A levels in hepatitis and liver cirrhosis were obviously higher than that in the normal control group (P<0.05), but the serum vitamin D 25(OH) D and 1,25(OH)2D levels were obviously lower than that in the normal control group (P<0.05). In patients with liver cirrhosis, Enterobacteriaceae was positively correlated with prothrombin time (PT), Enterococcus was positively correlated with alanine aminotransferase and aspartate aminotransferase (AST) levels, Bifidobacterium was negatively correlated with AST, alkline phosphatase (AKP) and HBV DNA levels, and Bacteroides was negatively correlated with AST level and PT. There was a significant negative correlation between serum IL-17A and total bilirubin in patients with liver cirrhosis, and 25(OH) D was negatively correlated with AST, AKP and HBV DNA levels. In patients with liver cirrhosis, there was significant positive correlation between Enterococcus and IL-17A, and between Lactobacillus and 25(OH)D, but other bacteria were not obviously associated with IL-17A and vitamin D. Intestinal flora imbalance, vitamin D deficiency and IL-17A imbalance play an important role in the evolution of liver cirrhosis.

Authors+Show Affiliations

Department of Public Health, Yantai Infectious Disease Hospital, Yantai, Shandong 264001, P.R. China.Outpatient Department, Yantai Infectious Disease Hospital, Yantai, Shandong 264001, P.R. China.Medical Department, Yantai Infectious Disease Hospital, Yantai, Shandong 264001, P.R. China.Department of Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao, University Medical College, Yantai, Shandong 264000, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30344685

Citation

Mou, Haijuan, et al. "Correlation of Liver Function With Intestinal Flora, Vitamin Deficiency and IL-17A in Patients With Liver Cirrhosis." Experimental and Therapeutic Medicine, vol. 16, no. 5, 2018, pp. 4082-4088.
Mou H, Yang F, Zhou J, et al. Correlation of liver function with intestinal flora, vitamin deficiency and IL-17A in patients with liver cirrhosis. Exp Ther Med. 2018;16(5):4082-4088.
Mou, H., Yang, F., Zhou, J., & Bao, C. (2018). Correlation of liver function with intestinal flora, vitamin deficiency and IL-17A in patients with liver cirrhosis. Experimental and Therapeutic Medicine, 16(5), pp. 4082-4088. doi:10.3892/etm.2018.6663.
Mou H, et al. Correlation of Liver Function With Intestinal Flora, Vitamin Deficiency and IL-17A in Patients With Liver Cirrhosis. Exp Ther Med. 2018;16(5):4082-4088. PubMed PMID: 30344685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of liver function with intestinal flora, vitamin deficiency and IL-17A in patients with liver cirrhosis. AU - Mou,Haijuan, AU - Yang,Fengying, AU - Zhou,Jianqin, AU - Bao,Cuixia, Y1 - 2018/08/29/ PY - 2018/01/03/received PY - 2018/07/27/accepted PY - 2018/10/23/entrez PY - 2018/10/23/pubmed PY - 2018/10/23/medline KW - chronic hepatitis B KW - interleukin-17A KW - intestinal flora KW - liver cirrhosis KW - vitamin D SP - 4082 EP - 4088 JF - Experimental and therapeutic medicine JO - Exp Ther Med VL - 16 IS - 5 N2 - The aim of this study was to investigate the correlation of liver function, intestinal flora, vitamin D and interleukin-17A (IL-17A) levels in patients with liver cirrhosis. A total of 52 patients diagnosed with posthepatitic cirrhosis and admitted into Yantai Infectious Disease Hospital (Yantai, China) from January to December in 2012 (liver cirrhosis group), and 52 patients with chronic hepatitis B (hepatitis group), and 40 healthy volunteers receiving physical examination in the hospital (normal control group) were selected into the study. The liver function, hepatitis B virus (HBV) deoxyribonucleic acid (DNA) level, intestinal flora distribution, vitamin D and IL-17A levels of all patients were detected, and the correlation among them was analyzed via Pearson's analysis. The number of Enterobacteriaceae, Enterococcus, Staphylococcus aureus and Saccharomyces in hepatitis and liver cirrhosis groups was significantly greater than in the normal control group (P<0.05), but the number of Lactobacillus, Bacteroides, Bifidobacterium and Clostridium was significantly decreased (P<0.05); the serum IL-17A levels in hepatitis and liver cirrhosis were obviously higher than that in the normal control group (P<0.05), but the serum vitamin D 25(OH) D and 1,25(OH)2D levels were obviously lower than that in the normal control group (P<0.05). In patients with liver cirrhosis, Enterobacteriaceae was positively correlated with prothrombin time (PT), Enterococcus was positively correlated with alanine aminotransferase and aspartate aminotransferase (AST) levels, Bifidobacterium was negatively correlated with AST, alkline phosphatase (AKP) and HBV DNA levels, and Bacteroides was negatively correlated with AST level and PT. There was a significant negative correlation between serum IL-17A and total bilirubin in patients with liver cirrhosis, and 25(OH) D was negatively correlated with AST, AKP and HBV DNA levels. In patients with liver cirrhosis, there was significant positive correlation between Enterococcus and IL-17A, and between Lactobacillus and 25(OH)D, but other bacteria were not obviously associated with IL-17A and vitamin D. Intestinal flora imbalance, vitamin D deficiency and IL-17A imbalance play an important role in the evolution of liver cirrhosis. SN - 1792-0981 UR - https://www.unboundmedicine.com/medline/citation/30344685/Correlation_of_liver_function_with_intestinal_flora_vitamin_deficiency_and_IL_17A_in_patients_with_liver_cirrhosis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30344685/ DB - PRIME DP - Unbound Medicine ER -