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Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy.
J Mol Neurosci. 2018 Dec; 66(4):512-523.JM

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42-induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42-induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ1-42 by inducing autophagy, indicating its potential therapeutic role in AD.

Authors+Show Affiliations

Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China.Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China. Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Endocrinology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Interventional Radiology, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.Department of Neurosurgery, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China.Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China. boxuqdhc@126.com.Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China. gangsunqdhc@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30345461

Citation

Yuan, Haicheng, et al. "Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis By Triggering Autophagy." Journal of Molecular Neuroscience : MN, vol. 66, no. 4, 2018, pp. 512-523.
Yuan H, Jiang C, Zhao J, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018;66(4):512-523.
Yuan, H., Jiang, C., Zhao, J., Zhao, Y., Zhang, Y., Xu, Y., Gao, X., Guo, L., Liu, Y., Liu, K., Xu, B., & Sun, G. (2018). Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. Journal of Molecular Neuroscience : MN, 66(4), 512-523. https://doi.org/10.1007/s12031-018-1175-2
Yuan H, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis By Triggering Autophagy. J Mol Neurosci. 2018;66(4):512-523. PubMed PMID: 30345461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. AU - Yuan,Haicheng, AU - Jiang,Chuanwu, AU - Zhao,Jingde, AU - Zhao,Yunsheng, AU - Zhang,Yongbin, AU - Xu,Yanqi, AU - Gao,Xiaoning, AU - Guo,Lingfei, AU - Liu,Yongji, AU - Liu,Kai, AU - Xu,Bo, AU - Sun,Gang, Y1 - 2018/10/22/ PY - 2018/06/24/received PY - 2018/09/14/accepted PY - 2018/10/23/pubmed PY - 2019/1/11/medline PY - 2018/10/23/entrez KW - Alzheimer’s disease KW - Autophagy KW - Euxanthone SP - 512 EP - 523 JF - Journal of molecular neuroscience : MN JO - J. Mol. Neurosci. VL - 66 IS - 4 N2 - Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42-induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42-induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ1-42 by inducing autophagy, indicating its potential therapeutic role in AD. SN - 1559-1166 UR - https://www.unboundmedicine.com/medline/citation/30345461/Euxanthone_Attenuates_Aβ1_42_Induced_Oxidative_Stress_and_Apoptosis_by_Triggering_Autophagy_ L2 - https://dx.doi.org/10.1007/s12031-018-1175-2 DB - PRIME DP - Unbound Medicine ER -