Tags

Type your tag names separated by a space and hit enter

Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes.
Invest Ophthalmol Vis Sci 2018; 59(12):4880-4885IO

Abstract

Purpose

The purpose of this study was to document the distribution of the severity of myopic maculopathy in a cohort of highly myopic patients and to explore the associated risk factors.

Methods

A total of 890 Chinese highly myopes aged between 7 and 70 years (median age 19 years) and with spherical refraction -6.00 diopter (D) or worse in both eyes were investigated. All participants underwent detailed ophthalmic examination. Myopic maculopathy was graded into 5 categories according to the International Photographic Classification and Grading System using color fundus photographs: category 0, no myopic retinal lesions, category 1, tessellated fundus only; category 2, diffuse chorioretinal atrophy; category 3, patchy chorioretinal atrophy; category 4, macular atrophy. Category 2 or greater were further classified as clinically significant myopic maculopathy (CSMM).

Results

Data from 884 of 890 right eyes were available for analysis. The proportions of category 1, category 2, category 3, and category 4 were 20.0% (177 eyes), 20.2% (178 eyes), 2.6% (23 eyes), and 0.2% (2 eyes), respectively. The proportion of CSMM increased with more myopic refraction (odds ratio 1.57; 95% confidence interval: 1.46-1.68), longer axial length (odds ratio 2.97; 95% confidence interval: 2.50-3.53), and older age (40-70 years compared to 12-18 years, odds ratio 6.77; 95% confidence interval: 3.61-12.70). However, there was a higher proportion of CSMM in children aged 7 to 11 years than those aged 12 to 18 years (20.9% vs. 11.0%, P = 0.008).

Conclusions

Older age, more myopic refraction, and longer axial length were associated with more severe myopic maculopathy. Although CSMM was uncommon among younger participants, children with early-onset high myopia have a disproportionately increased risk.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Brien Holden Vision Institute, Sydney, Australia. School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Research School of Biology, Australian National University, Canberra, Australia.Brien Holden Vision Institute, Sydney, Australia. School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30347081

Citation

Xiao, Ou, et al. "Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes." Investigative Ophthalmology & Visual Science, vol. 59, no. 12, 2018, pp. 4880-4885.
Xiao O, Guo X, Wang D, et al. Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes. Invest Ophthalmol Vis Sci. 2018;59(12):4880-4885.
Xiao, O., Guo, X., Wang, D., Jong, M., Lee, P. Y., Chen, L., ... He, M. (2018). Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes. Investigative Ophthalmology & Visual Science, 59(12), pp. 4880-4885. doi:10.1167/iovs.18-24471.
Xiao O, et al. Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes. Invest Ophthalmol Vis Sci. 2018 10 1;59(12):4880-4885. PubMed PMID: 30347081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes. AU - Xiao,Ou, AU - Guo,Xinxing, AU - Wang,Decai, AU - Jong,Monica, AU - Lee,Pei Ying, AU - Chen,Linxing, AU - Morgan,Ian G, AU - Sankaridurg,Padmaja, AU - He,Mingguang, PY - 2018/10/23/entrez PY - 2018/10/23/pubmed PY - 2019/5/7/medline SP - 4880 EP - 4885 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 59 IS - 12 N2 - Purpose: The purpose of this study was to document the distribution of the severity of myopic maculopathy in a cohort of highly myopic patients and to explore the associated risk factors. Methods: A total of 890 Chinese highly myopes aged between 7 and 70 years (median age 19 years) and with spherical refraction -6.00 diopter (D) or worse in both eyes were investigated. All participants underwent detailed ophthalmic examination. Myopic maculopathy was graded into 5 categories according to the International Photographic Classification and Grading System using color fundus photographs: category 0, no myopic retinal lesions, category 1, tessellated fundus only; category 2, diffuse chorioretinal atrophy; category 3, patchy chorioretinal atrophy; category 4, macular atrophy. Category 2 or greater were further classified as clinically significant myopic maculopathy (CSMM). Results: Data from 884 of 890 right eyes were available for analysis. The proportions of category 1, category 2, category 3, and category 4 were 20.0% (177 eyes), 20.2% (178 eyes), 2.6% (23 eyes), and 0.2% (2 eyes), respectively. The proportion of CSMM increased with more myopic refraction (odds ratio 1.57; 95% confidence interval: 1.46-1.68), longer axial length (odds ratio 2.97; 95% confidence interval: 2.50-3.53), and older age (40-70 years compared to 12-18 years, odds ratio 6.77; 95% confidence interval: 3.61-12.70). However, there was a higher proportion of CSMM in children aged 7 to 11 years than those aged 12 to 18 years (20.9% vs. 11.0%, P = 0.008). Conclusions: Older age, more myopic refraction, and longer axial length were associated with more severe myopic maculopathy. Although CSMM was uncommon among younger participants, children with early-onset high myopia have a disproportionately increased risk. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/30347081/Distribution_and_Severity_of_Myopic_Maculopathy_Among_Highly_Myopic_Eyes_ DB - PRIME DP - Unbound Medicine ER -