Tags

Type your tag names separated by a space and hit enter

Aphasic status epilepticus preceding tumefactive left hemisphere lesion in anti-MOG antibody associated disease.
Mult Scler Relat Disord. 2019 Jan; 27:91-94.MS

Abstract

INTRODUCTION

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have recently been associated with epilepsy with FLAIR hyperintense cortical lesions on MRI. Association between anti-MOG antibodies and epilepsy without detectable structural brain lesion on MRI is unknown.

CASE REPORT

A 48-year-old right-handed man with a four-and-a-half year history of anti-MOG antibody associated demyelinating disease presented with persistent global aphasia. Brain MRI showed no new lesion or cortical lesion in the left hemisphere. Electroencephalogram, magnetoencephalography, and brain perfusion single-photon emission computed tomography suggested epileptic foci in the left temporal and parietal lobes, and the patient's aphasia transiently responded to intravenous diazepam, compatible with aphasic status epilepticus. Cerebrospinal fluid showed mildly elevated cell count and positive oligoclonal bands. The patient only partially responded to antiepileptic drugs but responded to steroid pulse therapy. Six months later, the patient again exhibited global aphasia. Brain MRI showed tumefactive white matter lesion in the left temporo-parietal lobes.

CONCLUSION

Autoimmune epilepsy without obvious causative lesion on MRI can be seen in the course of anti-MOG antibody associated demyelinating disease. The subsequent emergence of tumefactive lesion closely located to the epileptic foci may suggest some association between autoimmune epilepsy and demyelinating lesions.

Authors+Show Affiliations

Department of Neurology, The University of Tokyo, Tokyo, Japan.Department of Neurology, The University of Tokyo, Tokyo, Japan. Electronic address: mkurihara-tky@umin.ac.jp.Department of Neurology, The University of Tokyo, Tokyo, Japan.Department of Neurology, The University of Tokyo, Tokyo, Japan.Division of Nuclear Medicine, Department of Radiology, The University of Tokyo, Tokyo, Japan.Division of Nuclear Medicine, Department of Radiology, The University of Tokyo, Tokyo, Japan.Department of Clinical Laboratory, The University of Tokyo, Tokyo, Japan.Department of Neurology, Tohoku University, Miyagi, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan.Department of Neurology, Tohoku University, Miyagi, Japan; Department of Neurology, Yonezawa National Hospital, Yamagata, Japan.Department of Neurology, The University of Tokyo, Tokyo, Japan.Department of Neurology, The University of Tokyo, Tokyo, Japan.Department of Neurology, The University of Tokyo, Tokyo, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30347340

Citation

Katsuse, Kazuto, et al. "Aphasic Status Epilepticus Preceding Tumefactive Left Hemisphere Lesion in anti-MOG Antibody Associated Disease." Multiple Sclerosis and Related Disorders, vol. 27, 2019, pp. 91-94.
Katsuse K, Kurihara M, Sugiyama Y, et al. Aphasic status epilepticus preceding tumefactive left hemisphere lesion in anti-MOG antibody associated disease. Mult Scler Relat Disord. 2019;27:91-94.
Katsuse, K., Kurihara, M., Sugiyama, Y., Kodama, S., Takahashi, M., Momose, T., Yumoto, M., Kaneko, K., Takahashi, T., Kubota, A., Hayashi, T., & Toda, T. (2019). Aphasic status epilepticus preceding tumefactive left hemisphere lesion in anti-MOG antibody associated disease. Multiple Sclerosis and Related Disorders, 27, 91-94. https://doi.org/10.1016/j.msard.2018.10.012
Katsuse K, et al. Aphasic Status Epilepticus Preceding Tumefactive Left Hemisphere Lesion in anti-MOG Antibody Associated Disease. Mult Scler Relat Disord. 2019;27:91-94. PubMed PMID: 30347340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aphasic status epilepticus preceding tumefactive left hemisphere lesion in anti-MOG antibody associated disease. AU - Katsuse,Kazuto, AU - Kurihara,Masanori, AU - Sugiyama,Yusuke, AU - Kodama,Satoshi, AU - Takahashi,Miwako, AU - Momose,Toshimitsu, AU - Yumoto,Masato, AU - Kaneko,Kimihiko, AU - Takahashi,Toshiyuki, AU - Kubota,Akatsuki, AU - Hayashi,Toshihiro, AU - Toda,Tatsushi, Y1 - 2018/10/15/ PY - 2018/08/29/received PY - 2018/10/11/revised PY - 2018/10/14/accepted PY - 2018/10/23/pubmed PY - 2019/4/18/medline PY - 2018/10/23/entrez KW - Aphasia KW - Autoimmune epilepsy KW - Cortical encephalitis KW - Myelin oligodendrocyte glycoprotein KW - Tumefactive demyelinating lesion SP - 91 EP - 94 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 27 N2 - INTRODUCTION: Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have recently been associated with epilepsy with FLAIR hyperintense cortical lesions on MRI. Association between anti-MOG antibodies and epilepsy without detectable structural brain lesion on MRI is unknown. CASE REPORT: A 48-year-old right-handed man with a four-and-a-half year history of anti-MOG antibody associated demyelinating disease presented with persistent global aphasia. Brain MRI showed no new lesion or cortical lesion in the left hemisphere. Electroencephalogram, magnetoencephalography, and brain perfusion single-photon emission computed tomography suggested epileptic foci in the left temporal and parietal lobes, and the patient's aphasia transiently responded to intravenous diazepam, compatible with aphasic status epilepticus. Cerebrospinal fluid showed mildly elevated cell count and positive oligoclonal bands. The patient only partially responded to antiepileptic drugs but responded to steroid pulse therapy. Six months later, the patient again exhibited global aphasia. Brain MRI showed tumefactive white matter lesion in the left temporo-parietal lobes. CONCLUSION: Autoimmune epilepsy without obvious causative lesion on MRI can be seen in the course of anti-MOG antibody associated demyelinating disease. The subsequent emergence of tumefactive lesion closely located to the epileptic foci may suggest some association between autoimmune epilepsy and demyelinating lesions. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/30347340/Aphasic_status_epilepticus_preceding_tumefactive_left_hemisphere_lesion_in_anti_MOG_antibody_associated_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(18)30374-2 DB - PRIME DP - Unbound Medicine ER -