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Identification of Causative Ciguatoxins in Red Snappers Lutjanus bohar Implicated in Ciguatera Fish Poisonings in Vietnam.
Toxins (Basel). 2018 10 20; 10(10)T

Abstract

Ciguatera fish poisoning (CFP) is a type of food poisoning caused by the consumption of a variety of toxic ciguatera fish species in the tropical and subtropical waters. Although there have been a large number of suspected CFP cases in the Southeast Asian countries, few were confirmed with causative ciguatoxins (CTXs), and reliable information on the symptoms still remains rather limited. In the present study, CTXs in red snapper Lutjanus bohar, implicated in two suspected CFP cases in Vietnam in 2014 and 2016, were determined by use of the single-quadrupole selected ion monitoring (SIM) liquid chromatography/mass spectrometry (LC/MS). Ciguatoxin-1B (CTX-1B), 54-deoxyCTX-1B, and 52-epi-54-deoxyCTX-1B were detected in the red snapper by our LC/MS method. Moreover, CTX-1B, 54-deoxyCTX-1B, and 52-epi-54-deoxyCTX-1B were further identified by the time of flight (TOF) LC/MS with the exact mass spectrum. The CTX profile of the red snapper in Vietnam is similar to those of ciguatera fish from Australia, Okinawa Islands in Japan, Kiribati, and Hong Kong. This is the first comprehensive report unambiguously identifying the causative toxins in fish implicated with reliable information on the poisoning symptoms in CFP in Vietnam and/or Southeast Asian countries.

Links

Publisher Full Text
ncbi.nlm.nih.gov
mdpi.com
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Authors+Show Affiliations

Ha DV
Institute of Oceanography, Vietnam Academy of Science and Technology, 01 Cau Da, Nha Trang 650000, Vietnam. dvha@vast.org.vn.
Uesugi A
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. auesugi@affrc.go.jp.
Uchida H
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. huchida@affrc.go.jp.
Ky PX
Institute of Oceanography, Vietnam Academy of Science and Technology, 01 Cau Da, Nha Trang 650000, Vietnam. phamkx@vnio.org.vn.
Minh DQ
Institute of Oceanography, Vietnam Academy of Science and Technology, 01 Cau Da, Nha Trang 650000, Vietnam. qminh2005@yahoo.com.
Watanabe R
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. rwatanabe@affrc.go.jp.
Matsushima R
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. matsur@affrc.go.jp.
Oikawa H
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. oikawah@fra.affrc.go.jp.
Nagai S
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. snagai@affrc.go.jp.
Iwataki M
Asian Natural Environmental Science Center, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan. iwataki@anesc.u-tokyo.ac.jp.
Fukuyo Y
Asian Natural Environmental Science Center, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan. ufukuyo@mail.ecc.u-tokyo.ac.jp.
Suzuki T
National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama 236-8648, Japan. tsuzuki@affrc.go.jp.

MeSH

AnimalsCiguatera PoisoningCiguatoxinsEnvironmental MonitoringFishesFood ContaminationMice, Inbred ICRVietnam

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30347818

Citation

Ha, Dao Viet, et al. "Identification of Causative Ciguatoxins in Red Snappers Lutjanus Bohar Implicated in Ciguatera Fish Poisonings in Vietnam." Toxins, vol. 10, no. 10, 2018.
Ha DV, Uesugi A, Uchida H, et al. Identification of Causative Ciguatoxins in Red Snappers Lutjanus bohar Implicated in Ciguatera Fish Poisonings in Vietnam. Toxins (Basel). 2018;10(10).
Ha, D. V., Uesugi, A., Uchida, H., Ky, P. X., Minh, D. Q., Watanabe, R., Matsushima, R., Oikawa, H., Nagai, S., Iwataki, M., Fukuyo, Y., & Suzuki, T. (2018). Identification of Causative Ciguatoxins in Red Snappers Lutjanus bohar Implicated in Ciguatera Fish Poisonings in Vietnam. Toxins, 10(10). https://doi.org/10.3390/toxins10100420
Ha DV, et al. Identification of Causative Ciguatoxins in Red Snappers Lutjanus Bohar Implicated in Ciguatera Fish Poisonings in Vietnam. Toxins (Basel). 2018 10 20;10(10) PubMed PMID: 30347818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of Causative Ciguatoxins in Red Snappers Lutjanus bohar Implicated in Ciguatera Fish Poisonings in Vietnam. AU - Ha,Dao Viet, AU - Uesugi,Aya, AU - Uchida,Hajime, AU - Ky,Pham Xuan, AU - Minh,Dang Quoc, AU - Watanabe,Ryuichi, AU - Matsushima,Ryoji, AU - Oikawa,Hiroshi, AU - Nagai,Satoshi, AU - Iwataki,Mitsunori, AU - Fukuyo,Yasuwo, AU - Suzuki,Toshiyuki, Y1 - 2018/10/20/ PY - 2018/08/13/received PY - 2018/10/08/revised PY - 2018/10/17/accepted PY - 2018/10/24/entrez PY - 2018/10/24/pubmed PY - 2019/9/10/medline KW - LC/MS KW - TOF KW - Vietnam KW - ciguatera fish poisoning (CFP) KW - ciguatoxin-1B (CTX-1B) KW - red snapper JF - Toxins JO - Toxins (Basel) VL - 10 IS - 10 N2 - Ciguatera fish poisoning (CFP) is a type of food poisoning caused by the consumption of a variety of toxic ciguatera fish species in the tropical and subtropical waters. Although there have been a large number of suspected CFP cases in the Southeast Asian countries, few were confirmed with causative ciguatoxins (CTXs), and reliable information on the symptoms still remains rather limited. In the present study, CTXs in red snapper Lutjanus bohar, implicated in two suspected CFP cases in Vietnam in 2014 and 2016, were determined by use of the single-quadrupole selected ion monitoring (SIM) liquid chromatography/mass spectrometry (LC/MS). Ciguatoxin-1B (CTX-1B), 54-deoxyCTX-1B, and 52-epi-54-deoxyCTX-1B were detected in the red snapper by our LC/MS method. Moreover, CTX-1B, 54-deoxyCTX-1B, and 52-epi-54-deoxyCTX-1B were further identified by the time of flight (TOF) LC/MS with the exact mass spectrum. The CTX profile of the red snapper in Vietnam is similar to those of ciguatera fish from Australia, Okinawa Islands in Japan, Kiribati, and Hong Kong. This is the first comprehensive report unambiguously identifying the causative toxins in fish implicated with reliable information on the poisoning symptoms in CFP in Vietnam and/or Southeast Asian countries. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/30347818/Identification_of_Causative_Ciguatoxins_in_Red_Snappers_Lutjanus_bohar_Implicated_in_Ciguatera_Fish_Poisonings_in_Vietnam_ L2 - https://www.mdpi.com/resolver?pii=toxins10100420 DB - PRIME DP - Unbound Medicine ER -