Tags

Type your tag names separated by a space and hit enter

Biotransformation of anthocyanins from Vitis amurensis Rupr of "Beibinghong" extract by human intestinal microbiota.
Xenobiotica. 2019 Sep; 49(9):1025-1032.X

Abstract

1. Anthocyanins (ACNs) are a subclass of polyphenolic pigments belonging to the flavonoids and constitute an important group of human diets. There is accumulated evidence that consumption of ACN-rich diets such as Vitis amurensis Rupr of "Beibinghong" exerts protective activities against some human diseases. These beneficial properties may be due to the biotransformation by intestinal microbiota and its related bacterial dependent metabolism of ACNs. However, despite the compositional characterization of ACNs in extracts from V. amurensis Rupr, the biotransformation pathways of these compounds in the human intestinal tract have not been investigated so far. 2. In this study, the biotransformation of ACNs by the human intestinal microbiota and the derived metabolites were analyzed and characterized by RRLC-Q-TOF-MS and MS/MS methods. Eight kinds of ACNs were identified and could be bio-transformed under the action of human intestinal microbiota. The biotransformation pathway analysis showed that the microbiota acted by removing all glucosides to produce the corresponding aglycones, which were subsequently converted to phenolic acid and aldehydes. 3. These findings shed light on the mechanisms of ACNs degradation by the human intestinal microbiota and will lay a foundation for the industrial and pharmacological applications of the ACNs.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Zheng F
a College of Food Science and Engineering , Jilin Agricultural University , Changchun , China. b Jilin Ginseng Academy , Changchun University of Chinese Medicine , Changchun , China.
Han M
b Jilin Ginseng Academy , Changchun University of Chinese Medicine , Changchun , China.
He Y
a College of Food Science and Engineering , Jilin Agricultural University , Changchun , China.
Zhang Y
b Jilin Ginseng Academy , Changchun University of Chinese Medicine , Changchun , China.
Liu S
b Jilin Ginseng Academy , Changchun University of Chinese Medicine , Changchun , China.
Yue H
b Jilin Ginseng Academy , Changchun University of Chinese Medicine , Changchun , China.
Wen L
a College of Food Science and Engineering , Jilin Agricultural University , Changchun , China.

MeSH

AdultAnthocyaninsBiotransformationChromatography, LiquidGastrointestinal MicrobiomeHumansMalePlant ExtractsTandem Mass SpectrometryVitis

Pub Type(s)

Journal Article
Video-Audio Media

Language

eng

PubMed ID

30351210

Citation

Zheng, Fei, et al. "Biotransformation of Anthocyanins From Vitis Amurensis Rupr of "Beibinghong" Extract By Human Intestinal Microbiota." Xenobiotica; the Fate of Foreign Compounds in Biological Systems, vol. 49, no. 9, 2019, pp. 1025-1032.
Zheng F, Han M, He Y, et al. Biotransformation of anthocyanins from Vitis amurensis Rupr of "Beibinghong" extract by human intestinal microbiota. Xenobiotica. 2019;49(9):1025-1032.
Zheng, F., Han, M., He, Y., Zhang, Y., Liu, S., Yue, H., & Wen, L. (2019). Biotransformation of anthocyanins from Vitis amurensis Rupr of "Beibinghong" extract by human intestinal microbiota. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 49(9), 1025-1032. https://doi.org/10.1080/00498254.2018.1532132
Zheng F, et al. Biotransformation of Anthocyanins From Vitis Amurensis Rupr of "Beibinghong" Extract By Human Intestinal Microbiota. Xenobiotica. 2019;49(9):1025-1032. PubMed PMID: 30351210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biotransformation of anthocyanins from Vitis amurensis Rupr of "Beibinghong" extract by human intestinal microbiota. AU - Zheng,Fei, AU - Han,Mingxin, AU - He,Yang, AU - Zhang,Yan, AU - Liu,Shuying, AU - Yue,Hao, AU - Wen,Liankui, Y1 - 2019/01/04/ PY - 2018/10/24/pubmed PY - 2019/12/18/medline PY - 2018/10/24/entrez KW - Rupr KW - anthocyanins KW - biotransformation KW - intestinal microbiota KW - metabolism SP - 1025 EP - 1032 JF - Xenobiotica; the fate of foreign compounds in biological systems JO - Xenobiotica VL - 49 IS - 9 N2 - 1. Anthocyanins (ACNs) are a subclass of polyphenolic pigments belonging to the flavonoids and constitute an important group of human diets. There is accumulated evidence that consumption of ACN-rich diets such as Vitis amurensis Rupr of "Beibinghong" exerts protective activities against some human diseases. These beneficial properties may be due to the biotransformation by intestinal microbiota and its related bacterial dependent metabolism of ACNs. However, despite the compositional characterization of ACNs in extracts from V. amurensis Rupr, the biotransformation pathways of these compounds in the human intestinal tract have not been investigated so far. 2. In this study, the biotransformation of ACNs by the human intestinal microbiota and the derived metabolites were analyzed and characterized by RRLC-Q-TOF-MS and MS/MS methods. Eight kinds of ACNs were identified and could be bio-transformed under the action of human intestinal microbiota. The biotransformation pathway analysis showed that the microbiota acted by removing all glucosides to produce the corresponding aglycones, which were subsequently converted to phenolic acid and aldehydes. 3. These findings shed light on the mechanisms of ACNs degradation by the human intestinal microbiota and will lay a foundation for the industrial and pharmacological applications of the ACNs. SN - 1366-5928 UR - https://www.unboundmedicine.com/medline/citation/30351210/Biotransformation_of_anthocyanins_from_Vitis_amurensis_Rupr_of_"Beibinghong"_extract_by_human_intestinal_microbiota_ DB - PRIME DP - Unbound Medicine ER -