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Immune regulation in the aging retina.
Prog Retin Eye Res. 2019 03; 69:159-172.PR

Abstract

The retina is an immune privileged tissue, which is protected from external and internal insults by its blood-retina barriers and immune suppressive microenvironment. Apart from the avoidance and tolerance strategies, the retina is also protected by its own defense system, i.e., microglia and the complement system. The immune privilege and defense mechanisms work together to maintain retinal homeostasis. During aging, the retina is at an increased risk of developing various degenerative diseases such as age-related macular degeneration, diabetic retinopathy, and glaucomatous retinopathy. Previously, we have shown that aging induces a para-inflammatory response in the retina. In this review, we explore the impact of aging on retinal immune regulation and the connection between homeostatic control of retinal immune privilege and para-inflammation under aging conditions and present a view that may explain why aging puts the retina at risk of developing degenerative diseases.

Authors+Show Affiliations

Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, UK.Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, UK; Aier Eye Institute, Aier School of Ophthalmology, Central South University, China.Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, UK.Infection and Immunity, School of Medicine, University of Aberdeen, UK.Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, UK; Aier Eye Institute, Aier School of Ophthalmology, Central South University, China. Electronic address: heping.xu@qub.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30352305

Citation

Chen, Mei, et al. "Immune Regulation in the Aging Retina." Progress in Retinal and Eye Research, vol. 69, 2019, pp. 159-172.
Chen M, Luo C, Zhao J, et al. Immune regulation in the aging retina. Prog Retin Eye Res. 2019;69:159-172.
Chen, M., Luo, C., Zhao, J., Devarajan, G., & Xu, H. (2019). Immune regulation in the aging retina. Progress in Retinal and Eye Research, 69, 159-172. https://doi.org/10.1016/j.preteyeres.2018.10.003
Chen M, et al. Immune Regulation in the Aging Retina. Prog Retin Eye Res. 2019;69:159-172. PubMed PMID: 30352305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune regulation in the aging retina. AU - Chen,Mei, AU - Luo,Chang, AU - Zhao,Jiawu, AU - Devarajan,Gayathri, AU - Xu,Heping, Y1 - 2018/10/20/ PY - 2018/06/28/received PY - 2018/10/13/revised PY - 2018/10/19/accepted PY - 2018/10/24/pubmed PY - 2019/5/2/medline PY - 2018/10/24/entrez KW - Aging KW - Blood-retina barrier KW - Complement KW - Inflammation KW - Microglia KW - Retinal degeneration SP - 159 EP - 172 JF - Progress in retinal and eye research JO - Prog Retin Eye Res VL - 69 N2 - The retina is an immune privileged tissue, which is protected from external and internal insults by its blood-retina barriers and immune suppressive microenvironment. Apart from the avoidance and tolerance strategies, the retina is also protected by its own defense system, i.e., microglia and the complement system. The immune privilege and defense mechanisms work together to maintain retinal homeostasis. During aging, the retina is at an increased risk of developing various degenerative diseases such as age-related macular degeneration, diabetic retinopathy, and glaucomatous retinopathy. Previously, we have shown that aging induces a para-inflammatory response in the retina. In this review, we explore the impact of aging on retinal immune regulation and the connection between homeostatic control of retinal immune privilege and para-inflammation under aging conditions and present a view that may explain why aging puts the retina at risk of developing degenerative diseases. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/30352305/Immune_regulation_in_the_aging_retina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(18)30044-2 DB - PRIME DP - Unbound Medicine ER -