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Top-ranking drugs out of 3312 drug-induced liver injury cases evaluated by the Roussel Uclaf Causality Assessment Method.
Expert Opin Drug Metab Toxicol. 2018 Nov; 14(11):1169-1187.EO

Abstract

INTRODUCTION

A list presenting a valid ranking of drugs most commonly implicated is hardly to be found. Areas covered: Published cases of drug-induced liver injury (DILI) with verified causality using RUCAM (Roussel Uclaf Causality Assessment Method) were used for a ranking of drugs most commonly implicated in causing DILI. Expert opinion: RUCAM-based DILI cases were retrieved from 15 reports published by six international databases of DILI registries and three large medical centers, which provided 3312 cases. Overall 48 drugs with the highest number of DILI cases were listed. Among the top 10 ranking drugs implicated in causing DILI were, in decreasing order: amoxicillin-clavulanate, flucloxacilllin, atorvastatin, disulfiram, diclofenac, simvastatin, carbamazepine, ibuprofen, erythromycin, and anabolic steroids as bodybuilding agents. For these 10 drugs, respective DILI case numbers were highest for Amoxicillin-clavulanate (n=333) and lowest for anabolic steroids (n=26). The author classifies the databases of national DILI registries and large medical centers as best sources of drugs implicated in DILI. Presently discouraged is the use of the LiverTox website because many cases were derived from published cases of poor quality and could previously not be classified as DILI, calling for the inclusion of DILI cases with established causality by the updated RUCAM.

Authors+Show Affiliations

a Department of Internal Medicine II, Division of Gastroenterology and Hepatology , Klinikum Hanau , Hanau , Germany. b Academic Teaching Hospital of the Medical Faculty , Goethe University Frankfurt/Main , Frankfurt/Main , Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30354694

Citation

Teschke, Rolf. "Top-ranking Drugs Out of 3312 Drug-induced Liver Injury Cases Evaluated By the Roussel Uclaf Causality Assessment Method." Expert Opinion On Drug Metabolism & Toxicology, vol. 14, no. 11, 2018, pp. 1169-1187.
Teschke R. Top-ranking drugs out of 3312 drug-induced liver injury cases evaluated by the Roussel Uclaf Causality Assessment Method. Expert Opin Drug Metab Toxicol. 2018;14(11):1169-1187.
Teschke, R. (2018). Top-ranking drugs out of 3312 drug-induced liver injury cases evaluated by the Roussel Uclaf Causality Assessment Method. Expert Opinion On Drug Metabolism & Toxicology, 14(11), 1169-1187. https://doi.org/10.1080/17425255.2018.1539077
Teschke R. Top-ranking Drugs Out of 3312 Drug-induced Liver Injury Cases Evaluated By the Roussel Uclaf Causality Assessment Method. Expert Opin Drug Metab Toxicol. 2018;14(11):1169-1187. PubMed PMID: 30354694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Top-ranking drugs out of 3312 drug-induced liver injury cases evaluated by the Roussel Uclaf Causality Assessment Method. A1 - Teschke,Rolf, Y1 - 2018/10/29/ PY - 2018/10/26/pubmed PY - 2018/12/12/medline PY - 2018/10/26/entrez KW - DILI registries KW - Drug-induced liver injury KW - Roussel Uclaf Causality Assessment Method KW - alternative causes KW - clinical DILI centers KW - herb-induced liver injury SP - 1169 EP - 1187 JF - Expert opinion on drug metabolism & toxicology JO - Expert Opin Drug Metab Toxicol VL - 14 IS - 11 N2 - INTRODUCTION: A list presenting a valid ranking of drugs most commonly implicated is hardly to be found. Areas covered: Published cases of drug-induced liver injury (DILI) with verified causality using RUCAM (Roussel Uclaf Causality Assessment Method) were used for a ranking of drugs most commonly implicated in causing DILI. Expert opinion: RUCAM-based DILI cases were retrieved from 15 reports published by six international databases of DILI registries and three large medical centers, which provided 3312 cases. Overall 48 drugs with the highest number of DILI cases were listed. Among the top 10 ranking drugs implicated in causing DILI were, in decreasing order: amoxicillin-clavulanate, flucloxacilllin, atorvastatin, disulfiram, diclofenac, simvastatin, carbamazepine, ibuprofen, erythromycin, and anabolic steroids as bodybuilding agents. For these 10 drugs, respective DILI case numbers were highest for Amoxicillin-clavulanate (n=333) and lowest for anabolic steroids (n=26). The author classifies the databases of national DILI registries and large medical centers as best sources of drugs implicated in DILI. Presently discouraged is the use of the LiverTox website because many cases were derived from published cases of poor quality and could previously not be classified as DILI, calling for the inclusion of DILI cases with established causality by the updated RUCAM. SN - 1744-7607 UR - https://www.unboundmedicine.com/medline/citation/30354694/Top_ranking_drugs_out_of_3312_drug_induced_liver_injury_cases_evaluated_by_the_Roussel_Uclaf_Causality_Assessment_Method_ L2 - http://www.tandfonline.com/doi/full/10.1080/17425255.2018.1539077 DB - PRIME DP - Unbound Medicine ER -