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Atorvastatin potentiates the effect of selenomethionine on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis.
Curr Med Res Opin 2019; 35(4):675-681CM

Abstract

OBJECTIVE

In many studies, selenium supplementation decreased serum titers of thyroid antibodies. The aim of the study was to investigate whether statin therapy determines selenium action on thyroid autoimmunity.

METHODS

This prospective case-control study enrolled 42 euthyroid women with Hashimoto's thyroiditis and normal vitamin D status, 20 of whom had been treated with atorvastatin (40 mg daily) for at least 6 months. All patients received selenomethionine (200 µg daily) for 6 months. Plasma levels of lipids, serum titers of thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) antibodies, as well as serum levels of thyrotropin, free thyroid hormones, and 25-hydroxyvitamin D were determined at the beginning and at the end of the study.

RESULTS

At baseline, there were no differences between both treatment arms in plasma lipids, titers of thyroid antibodies, serum levels of thyrotropin, free thyroid hormones, and 25-hydroxyvitamin D. Selenometionine decreased titers of TPOAb (from 843 ± 228 to 562 ± 189 U/mL) and TgAb (from 795 ± 286 to 501 ± 216 U/mL) in atorvastatin-treated women, as well as titers of TPOAb (from 892 ± 247 to 705 ± 205 U/mL) and TgAb (from 810 ± 301 to 645 ± 224 U/mL) in statin-naive women. The changes in antibody titers were more pronounced in women receiving atorvastatin (between-group difference: 94 [32-156] [TPOAb]; 129 [52-206] [TgAb]). Treatment-induced changes in TPOAb and TgAb correlated positively with baseline thyroid antibody titers. Circulating levels of lipids, free thyroxine, free triiodothyronine, and 25-hydroxyvitamin D remained at similar levels throughout the study.

CONCLUSIONS

The obtained results indicate that the decrease in titers of thyroid antibodies was potentiated by atorvastatin use.

Authors+Show Affiliations

a Department of Internal Medicine and Clinical Pharmacology , Medical University of Silesia , Katowice , Poland.a Department of Internal Medicine and Clinical Pharmacology , Medical University of Silesia , Katowice , Poland.a Department of Internal Medicine and Clinical Pharmacology , Medical University of Silesia , Katowice , Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30354702

Citation

Krysiak, Robert, et al. "Atorvastatin Potentiates the Effect of Selenomethionine On Thyroid Autoimmunity in Euthyroid Women With Hashimoto's Thyroiditis." Current Medical Research and Opinion, vol. 35, no. 4, 2019, pp. 675-681.
Krysiak R, Szkróbka W, Okopień B. Atorvastatin potentiates the effect of selenomethionine on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis. Curr Med Res Opin. 2019;35(4):675-681.
Krysiak, R., Szkróbka, W., & Okopień, B. (2019). Atorvastatin potentiates the effect of selenomethionine on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis. Current Medical Research and Opinion, 35(4), pp. 675-681. doi:10.1080/03007995.2018.1541314.
Krysiak R, Szkróbka W, Okopień B. Atorvastatin Potentiates the Effect of Selenomethionine On Thyroid Autoimmunity in Euthyroid Women With Hashimoto's Thyroiditis. Curr Med Res Opin. 2019;35(4):675-681. PubMed PMID: 30354702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atorvastatin potentiates the effect of selenomethionine on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2018/11/27/ PY - 2018/10/26/pubmed PY - 2018/10/26/medline PY - 2018/10/26/entrez KW - Hypothalamic-pituitary-thyroid axis KW - Selenium KW - Statins KW - Thyroiditis SP - 675 EP - 681 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 35 IS - 4 N2 - OBJECTIVE: In many studies, selenium supplementation decreased serum titers of thyroid antibodies. The aim of the study was to investigate whether statin therapy determines selenium action on thyroid autoimmunity. METHODS: This prospective case-control study enrolled 42 euthyroid women with Hashimoto's thyroiditis and normal vitamin D status, 20 of whom had been treated with atorvastatin (40 mg daily) for at least 6 months. All patients received selenomethionine (200 µg daily) for 6 months. Plasma levels of lipids, serum titers of thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) antibodies, as well as serum levels of thyrotropin, free thyroid hormones, and 25-hydroxyvitamin D were determined at the beginning and at the end of the study. RESULTS: At baseline, there were no differences between both treatment arms in plasma lipids, titers of thyroid antibodies, serum levels of thyrotropin, free thyroid hormones, and 25-hydroxyvitamin D. Selenometionine decreased titers of TPOAb (from 843 ± 228 to 562 ± 189 U/mL) and TgAb (from 795 ± 286 to 501 ± 216 U/mL) in atorvastatin-treated women, as well as titers of TPOAb (from 892 ± 247 to 705 ± 205 U/mL) and TgAb (from 810 ± 301 to 645 ± 224 U/mL) in statin-naive women. The changes in antibody titers were more pronounced in women receiving atorvastatin (between-group difference: 94 [32-156] [TPOAb]; 129 [52-206] [TgAb]). Treatment-induced changes in TPOAb and TgAb correlated positively with baseline thyroid antibody titers. Circulating levels of lipids, free thyroxine, free triiodothyronine, and 25-hydroxyvitamin D remained at similar levels throughout the study. CONCLUSIONS: The obtained results indicate that the decrease in titers of thyroid antibodies was potentiated by atorvastatin use. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/30354702/Atorvastatin_potentiates_the_effect_of_selenomethionine_on_thyroid_autoimmunity_in_euthyroid_women_with_Hashimoto's_thyroiditis_ L2 - http://www.tandfonline.com/doi/full/10.1080/03007995.2018.1541314 DB - PRIME DP - Unbound Medicine ER -