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Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial.
Am J Clin Nutr. 2018 12 01; 108(6):1229-1237.AJ

Abstract

Background

Flavanols are an important class of food bioactives that can improve vascular function even in healthy subjects. Cocoa flavanols (CFs) are composed principally of the monomer (-)-epicatechin (∼20%), with a degree of polymerisation (DP) of 1 (DP1), and oligomeric procyanidins (∼80%, DP2-10).

Objective

Our objective was to investigate the relative contribution of procyanidins and (-)-epicatechin to CF intake-related improvements in vascular function in healthy volunteers.

Design

In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 45 healthy men (aged 18-35 y) consumed the following once daily for 1 mo: 1) a DP1-10 cocoa extract containing 130 mg (-)-epicatechin and 560 mg procyanidins, 2) a DP2-10 cocoa extract containing 20 mg (-)-epicatechin and 540 mg procyanidins, or 3) a control capsule, which was flavanol-free but had identical micro- and macronutrient composition.

Results

Consumption of DP1-10, but not of either DP2-10 or the control capsule, significantly increased flow-mediated vasodilation (primary endpoint) and the concentration of structurally related (-)-epicatechin metabolites (SREMs) in the circulatory system while decreasing pulse wave velocity and blood pressure. Total cholesterol significantly decreased after daily intake of both DP1-10 and DP2-10 as compared with the control.

Conclusions

CF-related improvements in vascular function are predominantly related to the intake of flavanol monomers and circulating SREMs in healthy humans but not to the more abundant procyanidins and gut microbiome-derived CF catabolites. Reduction in total cholesterol was linked to consumption of procyanidins but not necessarily to that of (-)-epicatechin. This trial was registered at clinicaltrials.gov as NCT02728466.

Authors+Show Affiliations

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Dusseldorf, Dusseldorf, Germany.Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Dusseldorf, Dusseldorf, Germany.University of Surrey, Faculty of Health and Medical Sciences, Guildford, United Kingdom.Mars, Inc., McLean, VA.Nutrition Department, University of California, Davis, Davis, CA.Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Dusseldorf, Dusseldorf, Germany.Mars, Inc., McLean, VA.Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Dusseldorf, Dusseldorf, Germany. University of Surrey, Faculty of Health and Medical Sciences, Guildford, United Kingdom.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30358831

Citation

Rodriguez-Mateos, Ana, et al. "Assessing the Respective Contributions of Dietary Flavanol Monomers and Procyanidins in Mediating Cardiovascular Effects in Humans: Randomized, Controlled, Double-masked Intervention Trial." The American Journal of Clinical Nutrition, vol. 108, no. 6, 2018, pp. 1229-1237.
Rodriguez-Mateos A, Weber T, Skene SS, et al. Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial. Am J Clin Nutr. 2018;108(6):1229-1237.
Rodriguez-Mateos, A., Weber, T., Skene, S. S., Ottaviani, J. I., Crozier, A., Kelm, M., Schroeter, H., & Heiss, C. (2018). Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial. The American Journal of Clinical Nutrition, 108(6), 1229-1237. https://doi.org/10.1093/ajcn/nqy229
Rodriguez-Mateos A, et al. Assessing the Respective Contributions of Dietary Flavanol Monomers and Procyanidins in Mediating Cardiovascular Effects in Humans: Randomized, Controlled, Double-masked Intervention Trial. Am J Clin Nutr. 2018 12 1;108(6):1229-1237. PubMed PMID: 30358831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial. AU - Rodriguez-Mateos,Ana, AU - Weber,Timon, AU - Skene,Simon S, AU - Ottaviani,Javier I, AU - Crozier,Alan, AU - Kelm,Malte, AU - Schroeter,Hagen, AU - Heiss,Christian, PY - 2018/04/27/received PY - 2018/08/13/accepted PY - 2018/10/26/pubmed PY - 2019/9/7/medline PY - 2018/10/26/entrez SP - 1229 EP - 1237 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 108 IS - 6 N2 - Background: Flavanols are an important class of food bioactives that can improve vascular function even in healthy subjects. Cocoa flavanols (CFs) are composed principally of the monomer (-)-epicatechin (∼20%), with a degree of polymerisation (DP) of 1 (DP1), and oligomeric procyanidins (∼80%, DP2-10). Objective: Our objective was to investigate the relative contribution of procyanidins and (-)-epicatechin to CF intake-related improvements in vascular function in healthy volunteers. Design: In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 45 healthy men (aged 18-35 y) consumed the following once daily for 1 mo: 1) a DP1-10 cocoa extract containing 130 mg (-)-epicatechin and 560 mg procyanidins, 2) a DP2-10 cocoa extract containing 20 mg (-)-epicatechin and 540 mg procyanidins, or 3) a control capsule, which was flavanol-free but had identical micro- and macronutrient composition. Results: Consumption of DP1-10, but not of either DP2-10 or the control capsule, significantly increased flow-mediated vasodilation (primary endpoint) and the concentration of structurally related (-)-epicatechin metabolites (SREMs) in the circulatory system while decreasing pulse wave velocity and blood pressure. Total cholesterol significantly decreased after daily intake of both DP1-10 and DP2-10 as compared with the control. Conclusions: CF-related improvements in vascular function are predominantly related to the intake of flavanol monomers and circulating SREMs in healthy humans but not to the more abundant procyanidins and gut microbiome-derived CF catabolites. Reduction in total cholesterol was linked to consumption of procyanidins but not necessarily to that of (-)-epicatechin. This trial was registered at clinicaltrials.gov as NCT02728466. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/30358831/Assessing_the_respective_contributions_of_dietary_flavanol_monomers_and_procyanidins_in_mediating_cardiovascular_effects_in_humans:_randomized_controlled_double_masked_intervention_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/nqy229 DB - PRIME DP - Unbound Medicine ER -