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Disorders of the autonomic nervous system: Part 1. Pathophysiology and clinical features.
Ann Neurol. 1987 May; 21(5):419-30.AN

Abstract

Autonomic dysfunction may result from diseases that affect primarily either the central nervous system or the peripheral autonomic nervous system. The most common pathogenesis of disturbed autonomic function in central nervous system diseases is degeneration of the intermediolateral cell columns (progressive autonomic failure) or disease or damage to descending pathways that synapse on the intermediolateral column cells (spinal cord lesions, cerebrovascular disease, brainstem tumors, multiple sclerosis). The peripheral autonomic nervous system may be damaged in isolation in the acute and subacute autonomic neuropathies or in association with a generalized peripheral neuropathy. The peripheral neuropathies most likely to cause severe autonomic disturbance are those in which small myelinated and unmyelinated fibers are damaged in the baroreflex afferents, the vagal efferents to the heart, and the sympathetic efferent pathways to the mesenteric vascular bed. Acute demyelination of the sympathetic and parasympathetic nerves in the Guillain-Barré syndrome may also cause acute autonomic dysfunction. Although autonomic disturbances may occur in other types of peripheral neuropathy, they are rarely clinically important.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3035997

Citation

McLeod, J G., and R R. Tuck. "Disorders of the Autonomic Nervous System: Part 1. Pathophysiology and Clinical Features." Annals of Neurology, vol. 21, no. 5, 1987, pp. 419-30.
McLeod JG, Tuck RR. Disorders of the autonomic nervous system: Part 1. Pathophysiology and clinical features. Ann Neurol. 1987;21(5):419-30.
McLeod, J. G., & Tuck, R. R. (1987). Disorders of the autonomic nervous system: Part 1. Pathophysiology and clinical features. Annals of Neurology, 21(5), 419-30.
McLeod JG, Tuck RR. Disorders of the Autonomic Nervous System: Part 1. Pathophysiology and Clinical Features. Ann Neurol. 1987;21(5):419-30. PubMed PMID: 3035997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disorders of the autonomic nervous system: Part 1. Pathophysiology and clinical features. AU - McLeod,J G, AU - Tuck,R R, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 419 EP - 30 JF - Annals of neurology JO - Ann Neurol VL - 21 IS - 5 N2 - Autonomic dysfunction may result from diseases that affect primarily either the central nervous system or the peripheral autonomic nervous system. The most common pathogenesis of disturbed autonomic function in central nervous system diseases is degeneration of the intermediolateral cell columns (progressive autonomic failure) or disease or damage to descending pathways that synapse on the intermediolateral column cells (spinal cord lesions, cerebrovascular disease, brainstem tumors, multiple sclerosis). The peripheral autonomic nervous system may be damaged in isolation in the acute and subacute autonomic neuropathies or in association with a generalized peripheral neuropathy. The peripheral neuropathies most likely to cause severe autonomic disturbance are those in which small myelinated and unmyelinated fibers are damaged in the baroreflex afferents, the vagal efferents to the heart, and the sympathetic efferent pathways to the mesenteric vascular bed. Acute demyelination of the sympathetic and parasympathetic nerves in the Guillain-Barré syndrome may also cause acute autonomic dysfunction. Although autonomic disturbances may occur in other types of peripheral neuropathy, they are rarely clinically important. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/3035997/Disorders_of_the_autonomic_nervous_system:_Part_1__Pathophysiology_and_clinical_features_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1987&volume=21&issue=5&spage=419 DB - PRIME DP - Unbound Medicine ER -