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Intrauterine Fetal Growth Delay During Late Pregnancy After Maternal Gastric Bypass Surgery.
Ultraschall Med. 2020 Feb; 41(1):52-59.UM

Abstract

PURPOSE

To investigate intrauterine fetal growth development and birth anthropometry of fetuses conceived after maternal gastric bypass surgery.

MATERIALS AND METHODS

Longitudinal cohort study describing longitudinal growth estimated by ultrasound on 43 singleton pregnancies after gastric bypass compared to 43 BMI-matched controls.

RESULTS

In fetuses after maternal gastric bypass surgery, growth percentiles decreased markedly from the beginning of the second trimester until the end of the third trimester (decrease of 3.1 fetal abdomen circumference percentiles (95 %CI 0.9-5.3, p = 0.007) per four gestational weeks). While in the second trimester, fetal anthropometric measures did not differ between the groups, the mean abdomen circumference percentiles appeared significantly smaller during the third trimester in offspring of mothers after gastric bypass (mean difference 25.1 percentiles, p < 0.001). Similar tendencies have been observed in estimated fetal weight resulting in significantly more SGA offspring at delivery in the gastric bypass group. In children born after maternal gastric bypass surgery, weight percentiles (32.12th vs. 55.86th percentile, p < 0.001) as well as placental weight (525.2 g vs. 635.7 g, p < 0.001) were significantly reduced compared to controls.

CONCLUSION

In fetuses conceived after maternal gastric bypass, intrauterine fetal growth distinctively declined in the second and third trimester, most prominently observed in fetal abdomen circumferences. Birth weight and placental weight at birth was significantly lower compared to BMI-matched controls, possibly due to altered maternal metabolic factors and comparable to mothers experiencing chronic hunger episodes.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria. Wunschbaby Institut Feichtinger, Vienna, Austria. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30360008

Citation

Feichtinger, Michael, et al. "Intrauterine Fetal Growth Delay During Late Pregnancy After Maternal Gastric Bypass Surgery." Ultraschall in Der Medizin (Stuttgart, Germany : 1980), vol. 41, no. 1, 2020, pp. 52-59.
Feichtinger M, Falcone V, Schoenleitner T, et al. Intrauterine Fetal Growth Delay During Late Pregnancy After Maternal Gastric Bypass Surgery. Ultraschall Med. 2020;41(1):52-59.
Feichtinger, M., Falcone, V., Schoenleitner, T., Stopp, T., Husslein, P. W., Eppel, W., Chalubinski, K. M., & Göbl, C. S. (2020). Intrauterine Fetal Growth Delay During Late Pregnancy After Maternal Gastric Bypass Surgery. Ultraschall in Der Medizin (Stuttgart, Germany : 1980), 41(1), 52-59. https://doi.org/10.1055/a-0651-0424
Feichtinger M, et al. Intrauterine Fetal Growth Delay During Late Pregnancy After Maternal Gastric Bypass Surgery. Ultraschall Med. 2020;41(1):52-59. PubMed PMID: 30360008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrauterine Fetal Growth Delay During Late Pregnancy After Maternal Gastric Bypass Surgery. AU - Feichtinger,Michael, AU - Falcone,Veronica, AU - Schoenleitner,Theresa, AU - Stopp,Tina, AU - Husslein,Peter Wolf, AU - Eppel,Wolfgang, AU - Chalubinski,Kinga M, AU - Göbl,Christian S, Y1 - 2018/10/25/ PY - 2018/10/26/pubmed PY - 2020/2/11/medline PY - 2018/10/26/entrez SP - 52 EP - 59 JF - Ultraschall in der Medizin (Stuttgart, Germany : 1980) JO - Ultraschall Med VL - 41 IS - 1 N2 - PURPOSE: To investigate intrauterine fetal growth development and birth anthropometry of fetuses conceived after maternal gastric bypass surgery. MATERIALS AND METHODS: Longitudinal cohort study describing longitudinal growth estimated by ultrasound on 43 singleton pregnancies after gastric bypass compared to 43 BMI-matched controls. RESULTS: In fetuses after maternal gastric bypass surgery, growth percentiles decreased markedly from the beginning of the second trimester until the end of the third trimester (decrease of 3.1 fetal abdomen circumference percentiles (95 %CI 0.9-5.3, p = 0.007) per four gestational weeks). While in the second trimester, fetal anthropometric measures did not differ between the groups, the mean abdomen circumference percentiles appeared significantly smaller during the third trimester in offspring of mothers after gastric bypass (mean difference 25.1 percentiles, p < 0.001). Similar tendencies have been observed in estimated fetal weight resulting in significantly more SGA offspring at delivery in the gastric bypass group. In children born after maternal gastric bypass surgery, weight percentiles (32.12th vs. 55.86th percentile, p < 0.001) as well as placental weight (525.2 g vs. 635.7 g, p < 0.001) were significantly reduced compared to controls. CONCLUSION: In fetuses conceived after maternal gastric bypass, intrauterine fetal growth distinctively declined in the second and third trimester, most prominently observed in fetal abdomen circumferences. Birth weight and placental weight at birth was significantly lower compared to BMI-matched controls, possibly due to altered maternal metabolic factors and comparable to mothers experiencing chronic hunger episodes. SN - 1438-8782 UR - https://www.unboundmedicine.com/medline/citation/30360008/Intrauterine_Fetal_Growth_Delay_During_Late_Pregnancy_After_Maternal_Gastric_Bypass_Surgery_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0651-0424 DB - PRIME DP - Unbound Medicine ER -