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The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: A Review.
Mov Disord Clin Pract 2016 Jan-Feb; 3(1):4-8MD

Abstract

Background

Cognitive and motor decline, along with psychiatric symptoms, have a major impact on independence, nursing home admission, caregiver burden, and mortality in Parkinson's disease (PD). The single most common genetic risk factor for developing PD is a mutation in the glucocerebrosidase (GBA) gene.

Methods

This work is a literature review regarding "GBA" and "Parkinson's disease" as conducted by PubMed search.

Results

There is a higher prevalence of cognitive decline and more rapid trajectory of disease progression in PD-GBA carriers, compared to noncarriers. PD-GBA carriers also have domain-specific cognitive impairment, particularly in visual memory tasks. PD-GBA carriers may also have a more aggressive motor phenotype than noncarriers.

Conclusions

Early identification of PD-GBA carriers may lead to targeted therapies and development of new treatments.

Authors+Show Affiliations

Department of Neurological Sciences Rush University Chicago Illinois USA.Department of Anatomy & Cell Biology Rush University Chicago Illinois USA.Department of Anatomy & Cell Biology Rush University Chicago Illinois USA.Department of Neurological Sciences Rush University Chicago Illinois USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30363594

Citation

Pal, Gian, et al. "The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: a Review." Movement Disorders Clinical Practice, vol. 3, no. 1, 2016, pp. 4-8.
Pal G, Robertson E, O'Keefe J, et al. The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: A Review. Mov Disord Clin Pract. 2016;3(1):4-8.
Pal, G., Robertson, E., O'Keefe, J., & Hall, D. (2016). The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: A Review. Movement Disorders Clinical Practice, 3(1), pp. 4-8. doi:10.1002/mdc3.12229.
Pal G, et al. The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: a Review. Mov Disord Clin Pract. 2016;3(1):4-8. PubMed PMID: 30363594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: A Review. AU - Pal,Gian, AU - Robertson,Erin, AU - O'Keefe,Joan, AU - Hall,Deborah, Y1 - 2015/09/16/ PY - 2015/03/11/received PY - 2015/05/21/revised PY - 2015/06/25/accepted PY - 2018/10/27/entrez PY - 2015/9/16/pubmed PY - 2015/9/16/medline KW - GBA KW - Parkinson's disease KW - genetics KW - glucocerebrosidase SP - 4 EP - 8 JF - Movement disorders clinical practice JO - Mov Disord Clin Pract VL - 3 IS - 1 N2 - Background: Cognitive and motor decline, along with psychiatric symptoms, have a major impact on independence, nursing home admission, caregiver burden, and mortality in Parkinson's disease (PD). The single most common genetic risk factor for developing PD is a mutation in the glucocerebrosidase (GBA) gene. Methods: This work is a literature review regarding "GBA" and "Parkinson's disease" as conducted by PubMed search. Results: There is a higher prevalence of cognitive decline and more rapid trajectory of disease progression in PD-GBA carriers, compared to noncarriers. PD-GBA carriers also have domain-specific cognitive impairment, particularly in visual memory tasks. PD-GBA carriers may also have a more aggressive motor phenotype than noncarriers. Conclusions: Early identification of PD-GBA carriers may lead to targeted therapies and development of new treatments. SN - 2330-1619 UR - https://www.unboundmedicine.com/medline/citation/30363594/The_Neuropsychiatric_and_Motor_Profile_of_GBA_Associated_Parkinson's_Disease:_A_Review_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30363594/ DB - PRIME DP - Unbound Medicine ER -