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Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis.
Int J Ophthalmol. 2018; 11(10):1649-1656.IJ

Abstract

AIM

To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ON.

METHODS

This prospective study was conducted at the Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Thailand, between January, 2015 and December, 2016. We enlisted patients over 18 years of age with history of ON and categorized patients into 4 groups: 1) aquaporin 4 antibodies (AQP4-IgG) positive; 2) multiple sclerosis (MS); 3) myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) positive; 4) idiopathic-ON patients. Healthy controls were also included during the same study period. All patients underwent complete ophthalmological examination and spectral domain optical coherence tomography (OCT) imaging to analyze RNFL and GCIPL thickness after at least 3mo since the last episode of acute ON. The generalized estimating equation (GEE) models were used to compare the data amongst ON groups.

RESULTS

Among 87 previous ON eyes from 57 patients (43 AQP4-IgG+ON, 17 MS-ON, 8 MOG-IgG+ON, and 19 idiopathic-ON), mean logMAR visual acuity of AQP4-IgG+ON, MS-ON, MOG-IgG+ON, and idiopathic-ON groups was 0.76±0.88, 0.12±0.25, 0.39±0.31, and 0.75±1.08, respectively. Average, superior, and inferior RNFL were significantly reduced in AQP4-IgG+ON, MOG-IgG+ON and idiopathic-ON eyes, relative to those of MS-ON. Differences were not statistically significant for RNFL or GCIPL between the AQP4-IgG+ON and MOG-IgG+ON groups, whereas visual acuity in MOG-IgG+ON was slightly, but not significantly, better (0.39 vs 0.76). Although RNFL thickness in MOG-IgG+ON was significantly reduced as compared to MS-ON, mean visual acuity and GCIPL were not different.

CONCLUSION

Thinning of superior and inferior quadrants of RNFL are more commonly seen in MOG-IgG+ON and AQP4-IgG+ON. Long term visual acuity in MOG-IgG+ON is often better than AQP4-IgG+ON, whereas the structural change from OCT is comparable.

Authors+Show Affiliations

Department of Ophthalmology, Naresuan University Hospital, Naresuan University, Phitsanulok 65000, Thailand.Department of Ophthalmology, Mettapracharak Hospital, Nakhon Pathom 73110, Thailand.Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Bumrungrad International Hospital, Bangkok 10110, Thailand.Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Bangkok Hospital Headquarters, Bangkok 10310, Thailand.Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.Department of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30364209

Citation

Mekhasingharak, Nattapong, et al. "Optical Coherence Tomography in Central Nervous System Demyelinating Diseases Related Optic Neuritis." International Journal of Ophthalmology, vol. 11, no. 10, 2018, pp. 1649-1656.
Mekhasingharak N, Laowanapiban P, Siritho S, et al. Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis. Int J Ophthalmol. 2018;11(10):1649-1656.
Mekhasingharak, N., Laowanapiban, P., Siritho, S., Satukijchai, C., Prayoonwiwat, N., Jitprapaikulsan, J., & Chirapapaisan, N. (2018). Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis. International Journal of Ophthalmology, 11(10), 1649-1656. https://doi.org/10.18240/ijo.2018.10.12
Mekhasingharak N, et al. Optical Coherence Tomography in Central Nervous System Demyelinating Diseases Related Optic Neuritis. Int J Ophthalmol. 2018;11(10):1649-1656. PubMed PMID: 30364209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis. AU - Mekhasingharak,Nattapong, AU - Laowanapiban,Poramaet, AU - Siritho,Sasitorn, AU - Satukijchai,Chanjira, AU - Prayoonwiwat,Naraporn, AU - Jitprapaikulsan,Jiraporn, AU - Chirapapaisan,Niphon, AU - ,, Y1 - 2018/10/18/ PY - 2017/10/18/received PY - 2018/04/10/accepted PY - 2018/10/27/entrez PY - 2018/10/27/pubmed PY - 2018/10/27/medline KW - multiple sclerosis KW - myelin oligodendrocyte glycoprotein antibody KW - neuromyelitis optica KW - optic neuritis KW - optical coherence tomography SP - 1649 EP - 1656 JF - International journal of ophthalmology JO - Int J Ophthalmol VL - 11 IS - 10 N2 - AIM: To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ON. METHODS: This prospective study was conducted at the Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Thailand, between January, 2015 and December, 2016. We enlisted patients over 18 years of age with history of ON and categorized patients into 4 groups: 1) aquaporin 4 antibodies (AQP4-IgG) positive; 2) multiple sclerosis (MS); 3) myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) positive; 4) idiopathic-ON patients. Healthy controls were also included during the same study period. All patients underwent complete ophthalmological examination and spectral domain optical coherence tomography (OCT) imaging to analyze RNFL and GCIPL thickness after at least 3mo since the last episode of acute ON. The generalized estimating equation (GEE) models were used to compare the data amongst ON groups. RESULTS: Among 87 previous ON eyes from 57 patients (43 AQP4-IgG+ON, 17 MS-ON, 8 MOG-IgG+ON, and 19 idiopathic-ON), mean logMAR visual acuity of AQP4-IgG+ON, MS-ON, MOG-IgG+ON, and idiopathic-ON groups was 0.76±0.88, 0.12±0.25, 0.39±0.31, and 0.75±1.08, respectively. Average, superior, and inferior RNFL were significantly reduced in AQP4-IgG+ON, MOG-IgG+ON and idiopathic-ON eyes, relative to those of MS-ON. Differences were not statistically significant for RNFL or GCIPL between the AQP4-IgG+ON and MOG-IgG+ON groups, whereas visual acuity in MOG-IgG+ON was slightly, but not significantly, better (0.39 vs 0.76). Although RNFL thickness in MOG-IgG+ON was significantly reduced as compared to MS-ON, mean visual acuity and GCIPL were not different. CONCLUSION: Thinning of superior and inferior quadrants of RNFL are more commonly seen in MOG-IgG+ON and AQP4-IgG+ON. Long term visual acuity in MOG-IgG+ON is often better than AQP4-IgG+ON, whereas the structural change from OCT is comparable. SN - 2222-3959 UR - https://www.unboundmedicine.com/medline/citation/30364209/Optical_coherence_tomography_in_central_nervous_system_demyelinating_diseases_related_optic_neuritis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30364209/ DB - PRIME DP - Unbound Medicine ER -