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Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations.
Int J Cancer. 2019 05 15; 144(10):2381-2389.IJ

Abstract

Oral microbiome may play an important role in cancer pathogenesis. However, no study has prospectively investigated the association of the oral microbiome with subsequent risk of developing colorectal cancer (CRC). We conducted a nested case-control study including 231 incident CRC cases and 462 controls within the Southern Community Cohort Study with 75% of the subjects being African-Americans. The controls were individually matched to cases based on age, ethnic group, smoking, season-of-study enrollment and recruitment method. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Multiple bacterial taxa showed an association with CRC risk at p <0.05. Oral pathogens Treponema denticola and Prevotella intermedia were associated with an increased risk of CRC, with odds ratios (ORs) and 95% confidence intervals (CIs) of 1.76(1.19-2.60) and 1.55(1.08-2.22), respectively, for the individuals carrying these bacteria compared to non-carriers. In the phylum Actinobacteria, Bifidobacteriaceae was more abundant among CRC patients than among controls. In the phylum Bacteroidetes, Prevotella denticola and Prevotella sp. oral taxon 300 were associated with an increased CRC risk, while Prevotella melaninogenica was associated with a decreased risk of CRC. In the phylum Firmicutes, Carnobacteriaceae, Streptococcaceae, Erysipelotrichaceae, Streptococcus, Solobacterium, Streptococcus sp. oral taxon 058 and Solobacterium moorei showed associations with a decreased risk of CRC. Most of these associations were observed among both African- and European-Americans. Most of the associations were not significant after Bonferroni correction for multiple testing, which may be conservative. Our study suggests that the oral microbiome may play a significant role in CRC etiology.

Authors+Show Affiliations

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

30365870

Citation

Yang, Yaohua, et al. "Prospective Study of Oral Microbiome and Colorectal Cancer Risk in Low-income and African American Populations." International Journal of Cancer, vol. 144, no. 10, 2019, pp. 2381-2389.
Yang Y, Cai Q, Shu XO, et al. Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. Int J Cancer. 2019;144(10):2381-2389.
Yang, Y., Cai, Q., Shu, X. O., Steinwandel, M. D., Blot, W. J., Zheng, W., & Long, J. (2019). Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. International Journal of Cancer, 144(10), 2381-2389. https://doi.org/10.1002/ijc.31941
Yang Y, et al. Prospective Study of Oral Microbiome and Colorectal Cancer Risk in Low-income and African American Populations. Int J Cancer. 2019 05 15;144(10):2381-2389. PubMed PMID: 30365870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. AU - Yang,Yaohua, AU - Cai,Qiuyin, AU - Shu,Xiao-Ou, AU - Steinwandel,Mark D, AU - Blot,William J, AU - Zheng,Wei, AU - Long,Jirong, Y1 - 2018/12/11/ PY - 2018/08/23/received PY - 2018/10/15/accepted PY - 2018/10/27/pubmed PY - 2019/8/7/medline PY - 2018/10/27/entrez KW - 16S rRNA KW - colorectal cancer KW - oral microbiome SP - 2381 EP - 2389 JF - International journal of cancer JO - Int J Cancer VL - 144 IS - 10 N2 - Oral microbiome may play an important role in cancer pathogenesis. However, no study has prospectively investigated the association of the oral microbiome with subsequent risk of developing colorectal cancer (CRC). We conducted a nested case-control study including 231 incident CRC cases and 462 controls within the Southern Community Cohort Study with 75% of the subjects being African-Americans. The controls were individually matched to cases based on age, ethnic group, smoking, season-of-study enrollment and recruitment method. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Multiple bacterial taxa showed an association with CRC risk at p <0.05. Oral pathogens Treponema denticola and Prevotella intermedia were associated with an increased risk of CRC, with odds ratios (ORs) and 95% confidence intervals (CIs) of 1.76(1.19-2.60) and 1.55(1.08-2.22), respectively, for the individuals carrying these bacteria compared to non-carriers. In the phylum Actinobacteria, Bifidobacteriaceae was more abundant among CRC patients than among controls. In the phylum Bacteroidetes, Prevotella denticola and Prevotella sp. oral taxon 300 were associated with an increased CRC risk, while Prevotella melaninogenica was associated with a decreased risk of CRC. In the phylum Firmicutes, Carnobacteriaceae, Streptococcaceae, Erysipelotrichaceae, Streptococcus, Solobacterium, Streptococcus sp. oral taxon 058 and Solobacterium moorei showed associations with a decreased risk of CRC. Most of these associations were observed among both African- and European-Americans. Most of the associations were not significant after Bonferroni correction for multiple testing, which may be conservative. Our study suggests that the oral microbiome may play a significant role in CRC etiology. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/30365870/Prospective_study_of_oral_microbiome_and_colorectal_cancer_risk_in_low_income_and_African_American_populations_ L2 - https://doi.org/10.1002/ijc.31941 DB - PRIME DP - Unbound Medicine ER -