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Association between atopic dermatitis, depression, and suicidal ideation: A systematic review and meta-analysis.
J Am Acad Dermatol 2019; 80(2):402-410JA

Abstract

BACKGROUND

Atopic dermatitis (AD) is associated with psychologic distress. However, previous studies found conflicting results about whether AD is associated with increased depression or suicidality.

OBJECTIVES

To determine the complex relationship between AD and depression.

METHODS

A systematic review of all published observational studies in the MEDLINE, PubMed, Embase, Global Resource for Eczema Trials (GREAT), Latin American and Caribbean Health Sciences (LILACS), the Cochrane Library, Scopus, and PsychInfo databases that analyzed depression in AD was performed. Two reviewers performed study title and/or abstract review and data abstraction. Pooled meta-analysis was performed by using random-effects weighting.

RESULTS

Overall, 106 studies met the inclusion criteria; 36 had sufficient data for meta-analysis. The prevalence of any depression was higher in persons with versus without AD (20.1% vs 14.8%). Similar results were found in sensitivity analyses of studies assessing clinical depression, depressive symptoms, and adults; studies with healthy controls; and studies of low and high study quality. AD was associated with significantly higher depression scale scores, parental depression, antidepressant use, and suicidality. No publication bias was detected.

LIMITATIONS

Individual-level data were not available.

CONCLUSIONS

Patients with AD have higher odds of depression and suicidality.

Authors+Show Affiliations

Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address: JonathanISilverberg@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30365995

Citation

Patel, Kevin R., et al. "Association Between Atopic Dermatitis, Depression, and Suicidal Ideation: a Systematic Review and Meta-analysis." Journal of the American Academy of Dermatology, vol. 80, no. 2, 2019, pp. 402-410.
Patel KR, Immaneni S, Singam V, et al. Association between atopic dermatitis, depression, and suicidal ideation: A systematic review and meta-analysis. J Am Acad Dermatol. 2019;80(2):402-410.
Patel, K. R., Immaneni, S., Singam, V., Rastogi, S., & Silverberg, J. I. (2019). Association between atopic dermatitis, depression, and suicidal ideation: A systematic review and meta-analysis. Journal of the American Academy of Dermatology, 80(2), pp. 402-410. doi:10.1016/j.jaad.2018.08.063.
Patel KR, et al. Association Between Atopic Dermatitis, Depression, and Suicidal Ideation: a Systematic Review and Meta-analysis. J Am Acad Dermatol. 2019;80(2):402-410. PubMed PMID: 30365995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between atopic dermatitis, depression, and suicidal ideation: A systematic review and meta-analysis. AU - Patel,Kevin R, AU - Immaneni,Supriya, AU - Singam,Vivek, AU - Rastogi,Supriya, AU - Silverberg,Jonathan I, Y1 - 2018/10/23/ PY - 2018/06/24/received PY - 2018/07/25/revised PY - 2018/08/28/accepted PY - 2018/10/27/pubmed PY - 2019/3/6/medline PY - 2018/10/27/entrez KW - antidepressant KW - atopic dermatitis KW - comorbidity KW - depression KW - eczema KW - evidence KW - mood KW - suicidal ideation KW - suicide SP - 402 EP - 410 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 80 IS - 2 N2 - BACKGROUND: Atopic dermatitis (AD) is associated with psychologic distress. However, previous studies found conflicting results about whether AD is associated with increased depression or suicidality. OBJECTIVES: To determine the complex relationship between AD and depression. METHODS: A systematic review of all published observational studies in the MEDLINE, PubMed, Embase, Global Resource for Eczema Trials (GREAT), Latin American and Caribbean Health Sciences (LILACS), the Cochrane Library, Scopus, and PsychInfo databases that analyzed depression in AD was performed. Two reviewers performed study title and/or abstract review and data abstraction. Pooled meta-analysis was performed by using random-effects weighting. RESULTS: Overall, 106 studies met the inclusion criteria; 36 had sufficient data for meta-analysis. The prevalence of any depression was higher in persons with versus without AD (20.1% vs 14.8%). Similar results were found in sensitivity analyses of studies assessing clinical depression, depressive symptoms, and adults; studies with healthy controls; and studies of low and high study quality. AD was associated with significantly higher depression scale scores, parental depression, antidepressant use, and suicidality. No publication bias was detected. LIMITATIONS: Individual-level data were not available. CONCLUSIONS: Patients with AD have higher odds of depression and suicidality. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/30365995/Association_between_atopic_dermatitis_depression_and_suicidal_ideation:_A_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(18)32758-0 DB - PRIME DP - Unbound Medicine ER -