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Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis.
Atten Defic Hyperact Disord. 2019 Sep; 11(3):221-232.AD

Abstract

The aim of this article was to assess the differences in serum 25(OH)D levels between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. We used the PubMed (1966-2017), Scopus (2004-2017), ClinicalTrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (2000-2017), and Google Scholar (2004-2017) databases. Statistical meta-analysis was performed with RevMan 5.3. Εight studies were finally included in the present meta-analysis with a total number of 11,324 children. Among them, 2655 were diagnosed with ADHD, while the remaining 8669 were recruited as healthy controls. All eight trials reported significantly lower serum concentrations of 25(OH)D in patients diagnosed with ADHD compared to healthy controls. The pooled data showed that there was a significant difference between the ADHD group and the control group (SMD = - 0.73, 95% CI [- 1.00, - 0.46]). The systematic review and meta-analysis of observational studies demonstrated an inverse association between serum 25(OH)D and young patients with ADHD. Large cohort studies are required to investigate whether vitamin D-deficient infants are more likely to develop ADHD in the future. Also, whether children with ADHD should be supplemented with higher doses of vitamin D3 remains to be confirmed through long-term controlled clinical trials.

Authors+Show Affiliations

Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece. lila.kotsi@yahoo.com.Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece.Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30367389

Citation

Kotsi, Evangelia, et al. "Vitamin D Levels in Children and Adolescents With Attention-deficit Hyperactivity Disorder (ADHD): a Meta-analysis." Attention Deficit and Hyperactivity Disorders, vol. 11, no. 3, 2019, pp. 221-232.
Kotsi E, Kotsi E, Perrea DN. Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis. Atten Defic Hyperact Disord. 2019;11(3):221-232.
Kotsi, E., Kotsi, E., & Perrea, D. N. (2019). Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis. Attention Deficit and Hyperactivity Disorders, 11(3), 221-232. https://doi.org/10.1007/s12402-018-0276-7
Kotsi E, Kotsi E, Perrea DN. Vitamin D Levels in Children and Adolescents With Attention-deficit Hyperactivity Disorder (ADHD): a Meta-analysis. Atten Defic Hyperact Disord. 2019;11(3):221-232. PubMed PMID: 30367389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis. AU - Kotsi,Evangelia, AU - Kotsi,Elisavet, AU - Perrea,Despina N, Y1 - 2018/10/26/ PY - 2018/04/07/received PY - 2018/10/17/accepted PY - 2018/10/28/pubmed PY - 2020/2/11/medline PY - 2018/10/28/entrez KW - ADHD KW - Adolescents KW - Attention-deficit hyperactivity disorder KW - Children KW - Vitamin D SP - 221 EP - 232 JF - Attention deficit and hyperactivity disorders JO - Atten Defic Hyperact Disord VL - 11 IS - 3 N2 - The aim of this article was to assess the differences in serum 25(OH)D levels between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. We used the PubMed (1966-2017), Scopus (2004-2017), ClinicalTrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (2000-2017), and Google Scholar (2004-2017) databases. Statistical meta-analysis was performed with RevMan 5.3. Εight studies were finally included in the present meta-analysis with a total number of 11,324 children. Among them, 2655 were diagnosed with ADHD, while the remaining 8669 were recruited as healthy controls. All eight trials reported significantly lower serum concentrations of 25(OH)D in patients diagnosed with ADHD compared to healthy controls. The pooled data showed that there was a significant difference between the ADHD group and the control group (SMD = - 0.73, 95% CI [- 1.00, - 0.46]). The systematic review and meta-analysis of observational studies demonstrated an inverse association between serum 25(OH)D and young patients with ADHD. Large cohort studies are required to investigate whether vitamin D-deficient infants are more likely to develop ADHD in the future. Also, whether children with ADHD should be supplemented with higher doses of vitamin D3 remains to be confirmed through long-term controlled clinical trials. SN - 1866-6647 UR - https://www.unboundmedicine.com/medline/citation/30367389/Vitamin_D_levels_in_children_and_adolescents_with_attention_deficit_hyperactivity_disorder__ADHD_:_a_meta_analysis_ L2 - https://dx.doi.org/10.1007/s12402-018-0276-7 DB - PRIME DP - Unbound Medicine ER -