Tags

Type your tag names separated by a space and hit enter

High-fat-diet-induced inflammation depresses the appetite of blunt snout bream (Megalobrama amblycephala) through the transcriptional regulation of leptin/mammalian target of rapamycin.
Br J Nutr 2018; 120(12):1422-1431BJ

Abstract

The aim of this article was to investigate the mechanism of appetite suppression induced by high-fat diets (HFD) in blunt snout bream (Megalobrama amblycephala). Fish (average initial weight 40·0 (sem 0·35) g) were fed diets with two fat levels (6 and 11 %) with four replicates. HFD feeding for 30 d could significantly increase the weight gain rate, but feeding for 60 d cannot. Food intake of M. amblycephala began to decline significantly in fish fed the HFD for 48 d. HFD feeding for 60 d significantly reduced the expression of neuropeptide Y and elevated the expression of cocaine- and amphetamine-regulated transcript (CART), actions both in favour of suppression of appetite. The activation of fatty acid sensing was partly responsible for the weakened appetite. In addition, inflammatory factors induced by the HFD may be involved in the regulation of appetite by increasing the secretion of leptin and then activating the mammalian target of rapamycin (mTOR). Lipopolysaccharide (LPS, 2·0 mg/kg of fish weight) was administered to induce inflammation, and sampling was performed after 3, 6, 9, 12, 18, 24 and 48 h of LPS injection. Within 6-24 h of LPS injection, the food intake and appetite of M. amblycephala decreased significantly, whereas the mRNA expression of leptin and mTOR increased significantly. Our results indicate that inflammatory cytokines may be the cause of appetite suppression in M. amblycephala fed a HFD.

Authors+Show Affiliations

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province,College of Animal Science and Technology,Nanjing Agricultural University,No. 1 Weigang Road,Nanjing 210095,Jiangsu Province,People's Republic of China.Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province,College of Animal Science and Technology,Nanjing Agricultural University,No. 1 Weigang Road,Nanjing 210095,Jiangsu Province,People's Republic of China.Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province,College of Animal Science and Technology,Nanjing Agricultural University,No. 1 Weigang Road,Nanjing 210095,Jiangsu Province,People's Republic of China.Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province,College of Animal Science and Technology,Nanjing Agricultural University,No. 1 Weigang Road,Nanjing 210095,Jiangsu Province,People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30370882

Citation

Dai, Yong-Jun, et al. "High-fat-diet-induced Inflammation Depresses the Appetite of Blunt Snout Bream (Megalobrama Amblycephala) Through the Transcriptional Regulation of Leptin/mammalian Target of Rapamycin." The British Journal of Nutrition, vol. 120, no. 12, 2018, pp. 1422-1431.
Dai YJ, Jiang GZ, Yuan XY, et al. High-fat-diet-induced inflammation depresses the appetite of blunt snout bream (Megalobrama amblycephala) through the transcriptional regulation of leptin/mammalian target of rapamycin. Br J Nutr. 2018;120(12):1422-1431.
Dai, Y. J., Jiang, G. Z., Yuan, X. Y., & Liu, W. B. (2018). High-fat-diet-induced inflammation depresses the appetite of blunt snout bream (Megalobrama amblycephala) through the transcriptional regulation of leptin/mammalian target of rapamycin. The British Journal of Nutrition, 120(12), pp. 1422-1431. doi:10.1017/S000711451800288X.
Dai YJ, et al. High-fat-diet-induced Inflammation Depresses the Appetite of Blunt Snout Bream (Megalobrama Amblycephala) Through the Transcriptional Regulation of Leptin/mammalian Target of Rapamycin. Br J Nutr. 2018;120(12):1422-1431. PubMed PMID: 30370882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-fat-diet-induced inflammation depresses the appetite of blunt snout bream (Megalobrama amblycephala) through the transcriptional regulation of leptin/mammalian target of rapamycin. AU - Dai,Yong-Jun, AU - Jiang,Guang-Zhen, AU - Yuan,Xiang-Yang, AU - Liu,Wen-Bin, Y1 - 2018/10/29/ PY - 2018/10/30/pubmed PY - 2019/9/10/medline PY - 2018/10/30/entrez KW - Megalobrama amblycephala KW - AKT protein kinase B KW - CART cocaine- and amphetamine-regulated transcript KW - CPT1 carnitine palmitoyltransferase 1 KW - FA fatty acid KW - FAT fatty acid translocase KW - HFD high-fat diet KW - IκB inhibitor of κB KW - LPS lipopolysaccharide KW - NFD normal-fat diet KW - NPY neuropeptide Y KW - SREBP1c sterol regulatory element-binding protein type 1c KW - mTOR mammalian target of rapamycin KW - Appetite KW - Food intake KW - High-fat diets KW - Inflammatory factors SP - 1422 EP - 1431 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 120 IS - 12 N2 - The aim of this article was to investigate the mechanism of appetite suppression induced by high-fat diets (HFD) in blunt snout bream (Megalobrama amblycephala). Fish (average initial weight 40·0 (sem 0·35) g) were fed diets with two fat levels (6 and 11 %) with four replicates. HFD feeding for 30 d could significantly increase the weight gain rate, but feeding for 60 d cannot. Food intake of M. amblycephala began to decline significantly in fish fed the HFD for 48 d. HFD feeding for 60 d significantly reduced the expression of neuropeptide Y and elevated the expression of cocaine- and amphetamine-regulated transcript (CART), actions both in favour of suppression of appetite. The activation of fatty acid sensing was partly responsible for the weakened appetite. In addition, inflammatory factors induced by the HFD may be involved in the regulation of appetite by increasing the secretion of leptin and then activating the mammalian target of rapamycin (mTOR). Lipopolysaccharide (LPS, 2·0 mg/kg of fish weight) was administered to induce inflammation, and sampling was performed after 3, 6, 9, 12, 18, 24 and 48 h of LPS injection. Within 6-24 h of LPS injection, the food intake and appetite of M. amblycephala decreased significantly, whereas the mRNA expression of leptin and mTOR increased significantly. Our results indicate that inflammatory cytokines may be the cause of appetite suppression in M. amblycephala fed a HFD. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/30370882/High_fat_diet_induced_inflammation_depresses_the_appetite_of_blunt_snout_bream__Megalobrama_amblycephala__through_the_transcriptional_regulation_of_leptin/mammalian_target_of_rapamycin_ L2 - https://www.cambridge.org/core/product/identifier/S000711451800288X/type/journal_article DB - PRIME DP - Unbound Medicine ER -