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Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
J Am Heart Assoc. 2018 10 02; 7(19):e009835.JA

Abstract

Background Previous studies have demonstrated a possible association between the induction of coenzyme Q10 (CoQ10) after statin treatment and statin-induced myopathy. However, whether CoQ10 supplementation ameliorates statin-induced myopathy remains unclear. Methods and Results PubMed, EMBASE , and Cochrane Library were searched to identify randomized controlled trials investigating the effect of CoQ10 on statin-induced myopathy. We calculated the pooled weighted mean difference (WMD) using a fixed-effect model and a random-effect model to assess the effects of CoQ10 supplementation on statin-associated muscle symptoms and plasma creatine kinase. The methodological quality of the studies was determined, according to the Cochrane Handbook. Publication bias was evaluated by a funnel plot, Egger regression test, and the Begg-Mazumdar correlation test. Twelve randomized controlled trials with a total of 575 patients were enrolled; of them, 294 patients were in the CoQ10 supplementation group and 281 were in the placebo group. Compared with placebo, CoQ10 supplementation ameliorated statin-associated muscle symptoms, such as muscle pain (WMD , -1.60; 95% confidence interval [ CI ], -1.75 to -1.44; P<0.001), muscle weakness (WMD , -2.28; 95% CI , -2.79 to -1.77; P=0.006), muscle cramp (WMD , -1.78; 95% CI , -2.31 to -1.24; P<0.001), and muscle tiredness (WMD , -1.75; 95% CI , -2.31 to -1.19; P<0.001), whereas no reduction in the plasma creatine kinase level was observed after CoQ10 supplementation (WMD , 0.09; 95% CI , -0.06 to 0.24; P=0.23). Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.

Authors+Show Affiliations

1 China Academy of Chinese Medical Sciences Beijing China. 4 Xiyuan Hospital China Academy of Traditional Chinese Beijing China.2 China Heart Institute of Chinese Medicine China Academy of Chinese Medical Sciences Beijing China.3 Beijing University of Traditional Chinese Medicine Beijing China. 4 Xiyuan Hospital China Academy of Traditional Chinese Beijing China.3 Beijing University of Traditional Chinese Medicine Beijing China. 4 Xiyuan Hospital China Academy of Traditional Chinese Beijing China.2 China Heart Institute of Chinese Medicine China Academy of Chinese Medical Sciences Beijing China. 4 Xiyuan Hospital China Academy of Traditional Chinese Beijing China.2 China Heart Institute of Chinese Medicine China Academy of Chinese Medical Sciences Beijing China. 4 Xiyuan Hospital China Academy of Traditional Chinese Beijing China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30371340

Citation

Qu, Hua, et al. "Effects of Coenzyme Q10 On Statin-Induced Myopathy: an Updated Meta-Analysis of Randomized Controlled Trials." Journal of the American Heart Association, vol. 7, no. 19, 2018, pp. e009835.
Qu H, Guo M, Chai H, et al. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2018;7(19):e009835.
Qu, H., Guo, M., Chai, H., Wang, W. T., Gao, Z. Y., & Shi, D. Z. (2018). Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of the American Heart Association, 7(19), e009835. https://doi.org/10.1161/JAHA.118.009835
Qu H, et al. Effects of Coenzyme Q10 On Statin-Induced Myopathy: an Updated Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2018 10 2;7(19):e009835. PubMed PMID: 30371340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials. AU - Qu,Hua, AU - Guo,Ming, AU - Chai,Hua, AU - Wang,Wen-Ting, AU - Gao,Zhu-Ye, AU - Shi,Da-Zhuo, PY - 2018/10/30/entrez PY - 2018/10/30/pubmed PY - 2019/11/13/medline KW - coenzyme Q10 KW - coronary disease KW - meta‐analysis KW - statin therapy KW - statin‐induced myopathy SP - e009835 EP - e009835 JF - Journal of the American Heart Association JO - J Am Heart Assoc VL - 7 IS - 19 N2 - Background Previous studies have demonstrated a possible association between the induction of coenzyme Q10 (CoQ10) after statin treatment and statin-induced myopathy. However, whether CoQ10 supplementation ameliorates statin-induced myopathy remains unclear. Methods and Results PubMed, EMBASE , and Cochrane Library were searched to identify randomized controlled trials investigating the effect of CoQ10 on statin-induced myopathy. We calculated the pooled weighted mean difference (WMD) using a fixed-effect model and a random-effect model to assess the effects of CoQ10 supplementation on statin-associated muscle symptoms and plasma creatine kinase. The methodological quality of the studies was determined, according to the Cochrane Handbook. Publication bias was evaluated by a funnel plot, Egger regression test, and the Begg-Mazumdar correlation test. Twelve randomized controlled trials with a total of 575 patients were enrolled; of them, 294 patients were in the CoQ10 supplementation group and 281 were in the placebo group. Compared with placebo, CoQ10 supplementation ameliorated statin-associated muscle symptoms, such as muscle pain (WMD , -1.60; 95% confidence interval [ CI ], -1.75 to -1.44; P<0.001), muscle weakness (WMD , -2.28; 95% CI , -2.79 to -1.77; P=0.006), muscle cramp (WMD , -1.78; 95% CI , -2.31 to -1.24; P<0.001), and muscle tiredness (WMD , -1.75; 95% CI , -2.31 to -1.19; P<0.001), whereas no reduction in the plasma creatine kinase level was observed after CoQ10 supplementation (WMD , 0.09; 95% CI , -0.06 to 0.24; P=0.23). Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy. SN - 2047-9980 UR - https://www.unboundmedicine.com/medline/citation/30371340/Effects_of_Coenzyme_Q10_on_Statin_Induced_Myopathy:_An_Updated_Meta_Analysis_of_Randomized_Controlled_Trials_ L2 - http://www.ahajournals.org/doi/full/10.1161/JAHA.118.009835?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -