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Screening of Novel Psychoactive Substances in Postmortem Matrices by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS).
J Anal Toxicol. 2018 Oct 01; 42(8):562-569.JA

Abstract

Novel psychoactive substances (NPS) are newly emerging compounds, natural and synthetic, that are often sold as "legal" alternatives to controlled substances. These substances can include phenethylamines, tryptamines, synthetic cathinones, piperazines and others. Most novel psychoactive substances and similar designer drugs are often based on the chemical backbone of classic drugs of abuse but are not regularly encountered in postmortem casework. These compounds may go undetected in forensic toxicology labs where suitable identification methods for NPS may not exist. In order to keep up with this ever-expanding list of pharmacologically active and toxicologically hazardous substances, there is an increased need for a screening panel suitable for postmortem human samples such as whole blood and urine. In order to address this increased prevalence of NPS, a method was developed and validated to identify 50 NPS in postmortem samples using liquid chromatography triple quadrupole mass spectrometry. The data presented here represents a validated liquid chromatography triple quadrupole mass spectrometry method to qualitatively identify NPS in postmortem samples. The limit of detection for all compounds was set at 2.5 ng/mL. To evaluate the prevalence of NPS in the region, blood and urine specimens from 110 postmortem cases were submitted for analysis based on initial screening results and/or case history. Of those cases, 28% were positive for several NPS, though only a few were included in the cause of death. The robustness of this method proves that it is suitable for the continual addition of newer substances, ensuring up-to-date simultaneous drug detection.

Authors+Show Affiliations

Nassau County Medical Examiner - Department of Forensic Toxicology, 2251 Hempstead Turnpike-Building R, East Meadow, NY, USA.Nassau County Medical Examiner - Department of Forensic Toxicology, 2251 Hempstead Turnpike-Building R, East Meadow, NY, USA.Nassau County Medical Examiner - Department of Forensic Toxicology, 2251 Hempstead Turnpike-Building R, East Meadow, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30371846

Citation

Fagiola, Michael, et al. "Screening of Novel Psychoactive Substances in Postmortem Matrices By Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS)." Journal of Analytical Toxicology, vol. 42, no. 8, 2018, pp. 562-569.
Fagiola M, Hahn T, Avella J. Screening of Novel Psychoactive Substances in Postmortem Matrices by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS). J Anal Toxicol. 2018;42(8):562-569.
Fagiola, M., Hahn, T., & Avella, J. (2018). Screening of Novel Psychoactive Substances in Postmortem Matrices by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS). Journal of Analytical Toxicology, 42(8), 562-569. https://doi.org/10.1093/jat/bky050
Fagiola M, Hahn T, Avella J. Screening of Novel Psychoactive Substances in Postmortem Matrices By Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS). J Anal Toxicol. 2018 Oct 1;42(8):562-569. PubMed PMID: 30371846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of Novel Psychoactive Substances in Postmortem Matrices by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS). AU - Fagiola,Michael, AU - Hahn,Timothy, AU - Avella,Joseph, PY - 2018/02/21/received PY - 2018/07/17/accepted PY - 2018/10/30/entrez PY - 2018/10/30/pubmed PY - 2019/1/12/medline SP - 562 EP - 569 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 42 IS - 8 N2 - Novel psychoactive substances (NPS) are newly emerging compounds, natural and synthetic, that are often sold as "legal" alternatives to controlled substances. These substances can include phenethylamines, tryptamines, synthetic cathinones, piperazines and others. Most novel psychoactive substances and similar designer drugs are often based on the chemical backbone of classic drugs of abuse but are not regularly encountered in postmortem casework. These compounds may go undetected in forensic toxicology labs where suitable identification methods for NPS may not exist. In order to keep up with this ever-expanding list of pharmacologically active and toxicologically hazardous substances, there is an increased need for a screening panel suitable for postmortem human samples such as whole blood and urine. In order to address this increased prevalence of NPS, a method was developed and validated to identify 50 NPS in postmortem samples using liquid chromatography triple quadrupole mass spectrometry. The data presented here represents a validated liquid chromatography triple quadrupole mass spectrometry method to qualitatively identify NPS in postmortem samples. The limit of detection for all compounds was set at 2.5 ng/mL. To evaluate the prevalence of NPS in the region, blood and urine specimens from 110 postmortem cases were submitted for analysis based on initial screening results and/or case history. Of those cases, 28% were positive for several NPS, though only a few were included in the cause of death. The robustness of this method proves that it is suitable for the continual addition of newer substances, ensuring up-to-date simultaneous drug detection. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/30371846/Screening_of_Novel_Psychoactive_Substances_in_Postmortem_Matrices_by_Liquid_Chromatography_Tandem_Mass_Spectrometry__LC_MS_MS__ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bky050 DB - PRIME DP - Unbound Medicine ER -