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Vitamin D and cardiovascular disease in chronic kidney disease.
Pediatr Nephrol. 2019 12; 34(12):2509-2522.PN

Abstract

Chronic kidney disease (CKD) is considered an independent risk factor for cardiovascular disease, with increased cardiovascular morbidity and mortality seen even in the early stages of CKD. Several studies have shown a high prevalence of vitamin D deficiency in individuals with CKD. Low vitamin D levels upregulate the renin-angiotensin-aldosterone system (RAAS), cause endothelial dysfunction, and increase inflammation. Epidemiological studies show an association between vitamin D deficiency and risk factors for cardiovascular disease, but a causal relationship has not been established. The high cardiovascular morbidity and mortality associated with CKD in adults requires therapies to decrease this elevated risk. However, results from several meta-analyses and randomized clinical trials in adults have not shown convincing evidence for the use of vitamin D therapy in improving cardiovascular outcomes. Lack of high-quality evidence from randomized clinical trials in children regarding the effectiveness and long-term safety of vitamin D treatment precludes any recommendations on its use to mitigate the cardiovascular burden of CKD.

Authors+Show Affiliations

State University of New York Downstate Medical Center, Brooklyn, NY, 11203, USA.Ross University School of Medicine, Portsmouth, Dominica.New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA. juk2013@med.cornell.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

30374603

Citation

Kaur, Gurpreet, et al. "Vitamin D and Cardiovascular Disease in Chronic Kidney Disease." Pediatric Nephrology (Berlin, Germany), vol. 34, no. 12, 2019, pp. 2509-2522.
Kaur G, Singh J, Kumar J. Vitamin D and cardiovascular disease in chronic kidney disease. Pediatr Nephrol. 2019;34(12):2509-2522.
Kaur, G., Singh, J., & Kumar, J. (2019). Vitamin D and cardiovascular disease in chronic kidney disease. Pediatric Nephrology (Berlin, Germany), 34(12), 2509-2522. https://doi.org/10.1007/s00467-018-4088-y
Kaur G, Singh J, Kumar J. Vitamin D and Cardiovascular Disease in Chronic Kidney Disease. Pediatr Nephrol. 2019;34(12):2509-2522. PubMed PMID: 30374603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and cardiovascular disease in chronic kidney disease. AU - Kaur,Gurpreet, AU - Singh,Jatinder, AU - Kumar,Juhi, Y1 - 2018/10/29/ PY - 2018/04/23/received PY - 2018/09/13/accepted PY - 2018/09/09/revised PY - 2018/10/31/pubmed PY - 2020/8/25/medline PY - 2018/10/31/entrez KW - Active vitamin D analogs KW - Cardiovascular risk KW - Children KW - Cholecalciferol KW - Chronic kidney disease KW - Ergocalciferol SP - 2509 EP - 2522 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 34 IS - 12 N2 - Chronic kidney disease (CKD) is considered an independent risk factor for cardiovascular disease, with increased cardiovascular morbidity and mortality seen even in the early stages of CKD. Several studies have shown a high prevalence of vitamin D deficiency in individuals with CKD. Low vitamin D levels upregulate the renin-angiotensin-aldosterone system (RAAS), cause endothelial dysfunction, and increase inflammation. Epidemiological studies show an association between vitamin D deficiency and risk factors for cardiovascular disease, but a causal relationship has not been established. The high cardiovascular morbidity and mortality associated with CKD in adults requires therapies to decrease this elevated risk. However, results from several meta-analyses and randomized clinical trials in adults have not shown convincing evidence for the use of vitamin D therapy in improving cardiovascular outcomes. Lack of high-quality evidence from randomized clinical trials in children regarding the effectiveness and long-term safety of vitamin D treatment precludes any recommendations on its use to mitigate the cardiovascular burden of CKD. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/30374603/Vitamin_D_and_cardiovascular_disease_in_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s00467-018-4088-y DB - PRIME DP - Unbound Medicine ER -