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Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats.
Pharm Biol. 2018 Dec; 56(1):535-547.PB

Abstract

CONTEXT

Crataegus aronia (syn. Azarolus L.) (Rosaceae) is used in traditional medicine due to its hypolipidaemic and antioxidant properties.

OBJECTIVES

This study investigates the effect of C. aronia whole plant aqueous extract on sperm parameter and testicular structure in control and non-alcoholic fatty liver disease (NAFLD)-induced rats.

MATERIALS AND METHODS

Male rats were divided into six groups (10 rats each) as control fed a standard diet (STD) (10% kcal), STD + C. aronia (200 mg/kg), high-fat diet (HFD) (45% kcal), HFD + C. aronia, HFD followed by C. aronia, and C. aronia followed by HFD. Rats were treated with C. aronia (once/day, orally) for four weeks.

RESULTS

Compared with STD rats, STD rats co-treated with C. aronia had lower hepatic triglycerides (0.58 vs. 0.42 mg/g) and cholesterol (5.4 vs. 3.27 mg/g) contents, higher levels of testosterone (8.43 vs. 10.9 ng/mL), luteinizing hormone (6.05 vs. 8.1 mIU/mL) and follicle-stimulating hormone (5.8 vs. 8.0 mIU/mL) and increased epididymis weight (1.28 vs. 1.5g) and sperm count (133.2 vs. 148.3 million/0.1 mg) and motility (66.8%vs. 77.6%). They showed increased testicular levels of glutathione (6.3 vs. 7.75 µM/L) and higher protein levels of Nrf2 (0.37 vs. 0.79), γ-glutamylcysteine synthetase (0.27 vs. 0.5) and superoxide dismutase (0.92 vs. 2.1). Concomitant or post-treatment of C. aronia to NAFLD rats prevented the declines in sperm parameters and damage in the testis by similar effects like those found in the STD rats.

DISCUSSION AND CONCLUSIONS

This study encourages the use of C. aronia in further future clinical studies.

Authors+Show Affiliations

a Department of Physiology , College of Medicine, King Khalid University , Abha , Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30375253

Citation

Dallak, Mohammad. "Crataegus Aronia Enhances Sperm Parameters and Preserves Testicular Architecture in Both Control and Non-alcoholic Fatty Liver Disease-induced Rats." Pharmaceutical Biology, vol. 56, no. 1, 2018, pp. 535-547.
Dallak M. Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats. Pharm Biol. 2018;56(1):535-547.
Dallak, M. (2018). Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats. Pharmaceutical Biology, 56(1), 535-547. https://doi.org/10.1080/13880209.2018.1523934
Dallak M. Crataegus Aronia Enhances Sperm Parameters and Preserves Testicular Architecture in Both Control and Non-alcoholic Fatty Liver Disease-induced Rats. Pharm Biol. 2018;56(1):535-547. PubMed PMID: 30375253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats. A1 - Dallak,Mohammad, PY - 2018/10/31/entrez PY - 2018/10/31/pubmed PY - 2019/1/5/medline KW - Testis KW - high-fat diet KW - oxidative stress KW - sperm KW - testosterone SP - 535 EP - 547 JF - Pharmaceutical biology JO - Pharm Biol VL - 56 IS - 1 N2 - CONTEXT: Crataegus aronia (syn. Azarolus L.) (Rosaceae) is used in traditional medicine due to its hypolipidaemic and antioxidant properties. OBJECTIVES: This study investigates the effect of C. aronia whole plant aqueous extract on sperm parameter and testicular structure in control and non-alcoholic fatty liver disease (NAFLD)-induced rats. MATERIALS AND METHODS: Male rats were divided into six groups (10 rats each) as control fed a standard diet (STD) (10% kcal), STD + C. aronia (200 mg/kg), high-fat diet (HFD) (45% kcal), HFD + C. aronia, HFD followed by C. aronia, and C. aronia followed by HFD. Rats were treated with C. aronia (once/day, orally) for four weeks. RESULTS: Compared with STD rats, STD rats co-treated with C. aronia had lower hepatic triglycerides (0.58 vs. 0.42 mg/g) and cholesterol (5.4 vs. 3.27 mg/g) contents, higher levels of testosterone (8.43 vs. 10.9 ng/mL), luteinizing hormone (6.05 vs. 8.1 mIU/mL) and follicle-stimulating hormone (5.8 vs. 8.0 mIU/mL) and increased epididymis weight (1.28 vs. 1.5g) and sperm count (133.2 vs. 148.3 million/0.1 mg) and motility (66.8%vs. 77.6%). They showed increased testicular levels of glutathione (6.3 vs. 7.75 µM/L) and higher protein levels of Nrf2 (0.37 vs. 0.79), γ-glutamylcysteine synthetase (0.27 vs. 0.5) and superoxide dismutase (0.92 vs. 2.1). Concomitant or post-treatment of C. aronia to NAFLD rats prevented the declines in sperm parameters and damage in the testis by similar effects like those found in the STD rats. DISCUSSION AND CONCLUSIONS: This study encourages the use of C. aronia in further future clinical studies. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/30375253/Crataegus_aronia_enhances_sperm_parameters_and_preserves_testicular_architecture_in_both_control_and_non_alcoholic_fatty_liver_disease_induced_rats_ L2 - http://www.tandfonline.com/doi/full/10.1080/13880209.2018.1523934 DB - PRIME DP - Unbound Medicine ER -