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Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing.
Transl Psychiatry. 2018 10 30; 8(1):238.TP

Abstract

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron emission tomography at baseline, 18 and 36 months: Only individuals categorised as "Aβ accumulators", and thus considered to be on the AD pathway, were included in the analysis (N = 77). The relationship between MeDi adherence, MeDi components, and change in cerebral Aβ load (baseline to 36 months) was evaluated using Generalised Linear Modelling, accounting for age, gender, education, Apolipoprotein E ε4 allele status, body mass index and total energy intake. Higher MeDi score was associated with less Aβ accumulation in our cohort (β = -0.01 ± 0.004, p = 0.0070). Of the individual MeDi score components, a high intake of fruit was associated with less accumulation of Aβ (β = -0.04 ± 0.01, p = 0.00036). Our results suggest MeDi adherence is associated with reduced cerebral AD pathology accumulation over time. When our results are considered collectively with previous data linking the MeDi to slower cognitive decline, it is apparent that MeDi adherence warrants further investigation in the quest to delay AD onset.

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Authors+Show Affiliations

Rainey-Smith SR
Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. s.rainey-smith@ecu.edu.au. Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia. s.rainey-smith@ecu.edu.au.
Gu Y
Taub Institute for Research of Alzheimer's Disease and the Ageing Brain, Columbia University, New York, NY, USA. Gertrude H. Sergievsky Centre, Columbia University, New York, NY, USA.
Gardener SL
Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia.
Doecke JD
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Brisbane, Queensland, Australia. Cooperative Research Centre for Mental Health, Carlton, VIC, Australia.
Villemagne VL
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
Brown BM
Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia. School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia.
Taddei K
Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia.
Laws SM
Cooperative Research Centre for Mental Health, Carlton, VIC, Australia. Collaborative Genomics Group, Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.
Sohrabi HR
Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia. School of Biomedical Sciences, Macquarie University, Macquarie Park, New South Wales, Australia.
Weinborn M
Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia. School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia.
Ames D
National Ageing Research Institute, Parkville, Victoria, Australia. Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia.
Fowler C
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Macaulay SL
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Brisbane, Queensland, Australia.
Maruff P
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. CogState Ltd., Melbourne, Victoria, Australia.
Masters CL
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Salvado O
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Brisbane, Queensland, Australia.
Rowe CC
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
Scarmeas N
Taub Institute for Research of Alzheimer's Disease and the Ageing Brain, Columbia University, New York, NY, USA. Gertrude H. Sergievsky Centre, Columbia University, New York, NY, USA. Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. Department of Social Medicine, Psychiatry, and Neurology, National and Kapodistrian University of Athens, Athens, Greece.
Martins RN
Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia. School of Biomedical Sciences, Macquarie University, Macquarie Park, New South Wales, Australia. School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Western Australia, Australia.

MeSH

AgedAged, 80 and overAgingAmyloid beta-PeptidesAustraliaBiomarkersCerebrumDiet, MediterraneanFemaleFollow-Up StudiesHumansLife StyleMaleMiddle AgedPositron-Emission Tomography

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30375373

Citation

Rainey-Smith, Stephanie R., et al. "Mediterranean Diet Adherence and Rate of Cerebral Aβ-amyloid Accumulation: Data From the Australian Imaging, Biomarkers and Lifestyle Study of Ageing." Translational Psychiatry, vol. 8, no. 1, 2018, p. 238.
Rainey-Smith SR, Gu Y, Gardener SL, et al. Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Transl Psychiatry. 2018;8(1):238.
Rainey-Smith, S. R., Gu, Y., Gardener, S. L., Doecke, J. D., Villemagne, V. L., Brown, B. M., Taddei, K., Laws, S. M., Sohrabi, H. R., Weinborn, M., Ames, D., Fowler, C., Macaulay, S. L., Maruff, P., Masters, C. L., Salvado, O., Rowe, C. C., Scarmeas, N., & Martins, R. N. (2018). Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Translational Psychiatry, 8(1), 238. https://doi.org/10.1038/s41398-018-0293-5
Rainey-Smith SR, et al. Mediterranean Diet Adherence and Rate of Cerebral Aβ-amyloid Accumulation: Data From the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Transl Psychiatry. 2018 10 30;8(1):238. PubMed PMID: 30375373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. AU - Rainey-Smith,Stephanie R, AU - Gu,Yian, AU - Gardener,Samantha L, AU - Doecke,James D, AU - Villemagne,Victor L, AU - Brown,Belinda M, AU - Taddei,Kevin, AU - Laws,Simon M, AU - Sohrabi,Hamid R, AU - Weinborn,Michael, AU - Ames,David, AU - Fowler,Christopher, AU - Macaulay,S Lance, AU - Maruff,Paul, AU - Masters,Colin L, AU - Salvado,Olivier, AU - Rowe,Christopher C, AU - Scarmeas,Nikolaos, AU - Martins,Ralph N, Y1 - 2018/10/30/ PY - 2018/02/19/received PY - 2018/07/24/accepted PY - 2018/07/15/revised PY - 2018/10/31/entrez PY - 2018/10/31/pubmed PY - 2019/4/19/medline SP - 238 EP - 238 JF - Translational psychiatry JO - Transl Psychiatry VL - 8 IS - 1 N2 - Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron emission tomography at baseline, 18 and 36 months: Only individuals categorised as "Aβ accumulators", and thus considered to be on the AD pathway, were included in the analysis (N = 77). The relationship between MeDi adherence, MeDi components, and change in cerebral Aβ load (baseline to 36 months) was evaluated using Generalised Linear Modelling, accounting for age, gender, education, Apolipoprotein E ε4 allele status, body mass index and total energy intake. Higher MeDi score was associated with less Aβ accumulation in our cohort (β = -0.01 ± 0.004, p = 0.0070). Of the individual MeDi score components, a high intake of fruit was associated with less accumulation of Aβ (β = -0.04 ± 0.01, p = 0.00036). Our results suggest MeDi adherence is associated with reduced cerebral AD pathology accumulation over time. When our results are considered collectively with previous data linking the MeDi to slower cognitive decline, it is apparent that MeDi adherence warrants further investigation in the quest to delay AD onset. SN - 2158-3188 UR - https://www.unboundmedicine.com/medline/citation/30375373/Mediterranean_diet_adherence_and_rate_of_cerebral_Aβ_amyloid_accumulation:_Data_from_the_Australian_Imaging_Biomarkers_and_Lifestyle_Study_of_Ageing_ DB - PRIME DP - Unbound Medicine ER -