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Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin.
Psychopharmacology (Berl). 2019 Feb; 236(2):641-655.P

Abstract

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. The present study investigated the effects of 50 and 100 mg/kg berberine (BRB) on recognition memory, oxidative stress, and purinergic neurotransmission, in a model of sporadic dementia of the Alzheimer's type induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats. Rats were submitted to ICV-STZ 3 mg/kg or saline, and 3 days later, were started on a treatment of BRB or saline for 21 days. The results demonstrated that BRB was effective in protecting against memory impairment, increased reactive oxygen species, and the subsequent increase in protein and lipid oxidation in the cerebral cortex and hippocampus, as well as δ-aminolevulinate dehydratase inhibition in the cerebral cortex. Moreover, the decrease in total thiols, and the reduced glutathione and glutathione S-transferase activity in the cerebral cortex and hippocampus of ICV-STZ rats, was prevented by BRB treatment. Besides an antioxidant effect, BRB treatment was capable of preventing decreases in ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase (EC-5'-Nt), and adenosine deaminase (ADA) activities in synaptosomes of the cerebral cortex and hippocampus. Thus, our data suggest that BRB exerts a neuroprotective effect on recognition memory, as well as on oxidative stress and oxidative stress-related damage, such as dysfunction of the purinergic system. This suggests that BRB may act as a promising multipotent agent for the treatment of AD.

Authors+Show Affiliations

Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. juliana_sorraila@hotmail.com. Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry of the Center of Natural and Exact Sciences of the Federal University of Santa Maria, Santa Maria, RS, Brazil. juliana_sorraila@hotmail.com.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós graduação em Medicina Veterinária, Centro de Ciência Rurais/Departamento de Clínica de Pequenos Animais, Laboratório de Patologia Clínica Veternária/Hospital Veterinário, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry of the Center of Natural and Exact Sciences of the Federal University of Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Laboratório de Neuropsicofarmacologia Universidade Federal de Santa Maria, Santa Maria, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry of the Center of Natural and Exact Sciences of the Federal University of Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Laboratório de Neuropsicofarmacologia Universidade Federal de Santa Maria, Santa Maria, Brazil.Programa de Pós graduação em Medicina Veterinária, Centro de Ciência Rurais/Departamento de Clínica de Pequenos Animais, Laboratório de Patologia Clínica Veternária/Hospital Veterinário, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Department of Small Animal Clinic, Center of Rural Sciences Federal University of Santa Maria, Santa Maria, RS, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30377748

Citation

de Oliveira, Juliana Sorraila, et al. "Neuroprotective Effects of Berberine On Recognition Memory Impairment, Oxidative Stress, and Damage to the Purinergic System in Rats Submitted to Intracerebroventricular Injection of Streptozotocin." Psychopharmacology, vol. 236, no. 2, 2019, pp. 641-655.
de Oliveira JS, Abdalla FH, Dornelles GL, et al. Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin. Psychopharmacology (Berl). 2019;236(2):641-655.
de Oliveira, J. S., Abdalla, F. H., Dornelles, G. L., Palma, T. V., Signor, C., da Silva Bernardi, J., Baldissarelli, J., Lenz, L. S., de Oliveira, V. A., Chitolina Schetinger, M. R., Melchiors Morsch, V. M., Rubin, M. A., & de Andrade, C. M. (2019). Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin. Psychopharmacology, 236(2), 641-655. https://doi.org/10.1007/s00213-018-5090-6
de Oliveira JS, et al. Neuroprotective Effects of Berberine On Recognition Memory Impairment, Oxidative Stress, and Damage to the Purinergic System in Rats Submitted to Intracerebroventricular Injection of Streptozotocin. Psychopharmacology (Berl). 2019;236(2):641-655. PubMed PMID: 30377748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin. AU - de Oliveira,Juliana Sorraila, AU - Abdalla,Fátima Husein, AU - Dornelles,Guilherme Lopes, AU - Palma,Taís Vidal, AU - Signor,Cristiane, AU - da Silva Bernardi,Jamile, AU - Baldissarelli,Jucimara, AU - Lenz,Luana Suéling, AU - de Oliveira,Vitor Antunes, AU - Chitolina Schetinger,Maria Rosa, AU - Melchiors Morsch,Vera Maria, AU - Rubin,Maribel Antonello, AU - de Andrade,Cinthia Melazzo, Y1 - 2018/10/30/ PY - 2018/03/05/received PY - 2018/10/21/accepted PY - 2018/11/1/pubmed PY - 2019/5/8/medline PY - 2018/11/1/entrez KW - Alzheimer KW - Antioxidant KW - Ectoenzymes KW - Reactive species SP - 641 EP - 655 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 236 IS - 2 N2 - Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. The present study investigated the effects of 50 and 100 mg/kg berberine (BRB) on recognition memory, oxidative stress, and purinergic neurotransmission, in a model of sporadic dementia of the Alzheimer's type induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats. Rats were submitted to ICV-STZ 3 mg/kg or saline, and 3 days later, were started on a treatment of BRB or saline for 21 days. The results demonstrated that BRB was effective in protecting against memory impairment, increased reactive oxygen species, and the subsequent increase in protein and lipid oxidation in the cerebral cortex and hippocampus, as well as δ-aminolevulinate dehydratase inhibition in the cerebral cortex. Moreover, the decrease in total thiols, and the reduced glutathione and glutathione S-transferase activity in the cerebral cortex and hippocampus of ICV-STZ rats, was prevented by BRB treatment. Besides an antioxidant effect, BRB treatment was capable of preventing decreases in ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase (EC-5'-Nt), and adenosine deaminase (ADA) activities in synaptosomes of the cerebral cortex and hippocampus. Thus, our data suggest that BRB exerts a neuroprotective effect on recognition memory, as well as on oxidative stress and oxidative stress-related damage, such as dysfunction of the purinergic system. This suggests that BRB may act as a promising multipotent agent for the treatment of AD. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/30377748/Neuroprotective_effects_of_berberine_on_recognition_memory_impairment_oxidative_stress_and_damage_to_the_purinergic_system_in_rats_submitted_to_intracerebroventricular_injection_of_streptozotocin_ L2 - https://dx.doi.org/10.1007/s00213-018-5090-6 DB - PRIME DP - Unbound Medicine ER -