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Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial.
J Hum Nutr Diet. 2019 04; 32(2):185-197.JH

Abstract

BACKGROUND

Childhood asthma is the most common respiratory disorder worldwide, being associated with increased morbidity and a decreased quality of life. Omega-3 fatty acids have anti-inflammatory and immunomodulating properties; however, their efficacy in asthma is controversial. The present study aimed to examine the efficacy of a Mediterranean diet supplemented with a high omega-3 'fatty' fish intake in Greek asthmatic children.

METHODS

A single-centred, 6-month, parallel randomised controlled trial compared the consumption of a Mediterranean diet supplemented with two meals of 150 g of cooked fatty fish weekly (intervention) with the usual diet (control) with respect to pulmonary function in children (aged 5-12 years) with mild asthma. Pulmonary function was assessed using spirometry and bronchial inflammation by fractional exhaled nitric oxide analysis.

RESULTS

Sixty-four children (52% male, 48% female) successfully completed the trial. Fatty fish intake increased in the intervention group from 17 g day-1 at baseline to 46 g day-1 at 6 months (P < 0.001). In the unadjusted analysis, the effect of the intervention was of borderline significance (P = 0.06, β = -11.93; 95% confidence interval = -24.32 to 0.46). However, after adjusting for age, sex, body mass index and regular physical activity, a significant effect was observed (P = 0.04, β = -14.15 ppb; 95% confidence interval = -27.39 to -0.91). No difference was observed for spirometry, asthma control and quality of life scores.

CONCLUSIONS

A Mediterranean diet supplemented with two fatty fish meals per week might be a potential strategy for reducing airway inflammation in childhood asthma. Future robust clinical trials are warranted to replicate and corroborate these findings.

Authors+Show Affiliations

Department of Rehabilitation, Nutrition & Sport, School of Allied Health, La Trobe University, Melbourne, VIC, Australia.National & Kapodistrian University of Athens, Athens, Greece.Department of Public Health, School of Psychology & Public Health, La Trobe University, Melbourne, VIC, Australia.European Institute of Nutritional Medicine, Rome, Italy.National & Kapodistrian University of Athens, Athens, Greece.Department of Public Health, School of Psychology & Public Health, La Trobe University, Melbourne, VIC, Australia.Department of Rehabilitation, Nutrition & Sport, School of Allied Health, La Trobe University, Melbourne, VIC, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30378203

Citation

Papamichael, M M., et al. "Efficacy of a Mediterranean Diet Supplemented With Fatty Fish in Ameliorating Inflammation in Paediatric Asthma: a Randomised Controlled Trial." Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, vol. 32, no. 2, 2019, pp. 185-197.
Papamichael MM, Katsardis C, Lambert K, et al. Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial. J Hum Nutr Diet. 2019;32(2):185-197.
Papamichael, M. M., Katsardis, C., Lambert, K., Tsoukalas, D., Koutsilieris, M., Erbas, B., & Itsiopoulos, C. (2019). Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial. Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, 32(2), 185-197. https://doi.org/10.1111/jhn.12609
Papamichael MM, et al. Efficacy of a Mediterranean Diet Supplemented With Fatty Fish in Ameliorating Inflammation in Paediatric Asthma: a Randomised Controlled Trial. J Hum Nutr Diet. 2019;32(2):185-197. PubMed PMID: 30378203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial. AU - Papamichael,M M, AU - Katsardis,Ch, AU - Lambert,K, AU - Tsoukalas,D, AU - Koutsilieris,M, AU - Erbas,B, AU - Itsiopoulos,C, Y1 - 2018/10/30/ PY - 2018/11/1/pubmed PY - 2020/6/25/medline PY - 2018/11/1/entrez KW - asthma KW - bronchial inflammation KW - children KW - fatty fish KW - omega-3 fatty acids SP - 185 EP - 197 JF - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JO - J Hum Nutr Diet VL - 32 IS - 2 N2 - BACKGROUND: Childhood asthma is the most common respiratory disorder worldwide, being associated with increased morbidity and a decreased quality of life. Omega-3 fatty acids have anti-inflammatory and immunomodulating properties; however, their efficacy in asthma is controversial. The present study aimed to examine the efficacy of a Mediterranean diet supplemented with a high omega-3 'fatty' fish intake in Greek asthmatic children. METHODS: A single-centred, 6-month, parallel randomised controlled trial compared the consumption of a Mediterranean diet supplemented with two meals of 150 g of cooked fatty fish weekly (intervention) with the usual diet (control) with respect to pulmonary function in children (aged 5-12 years) with mild asthma. Pulmonary function was assessed using spirometry and bronchial inflammation by fractional exhaled nitric oxide analysis. RESULTS: Sixty-four children (52% male, 48% female) successfully completed the trial. Fatty fish intake increased in the intervention group from 17 g day-1 at baseline to 46 g day-1 at 6 months (P < 0.001). In the unadjusted analysis, the effect of the intervention was of borderline significance (P = 0.06, β = -11.93; 95% confidence interval = -24.32 to 0.46). However, after adjusting for age, sex, body mass index and regular physical activity, a significant effect was observed (P = 0.04, β = -14.15 ppb; 95% confidence interval = -27.39 to -0.91). No difference was observed for spirometry, asthma control and quality of life scores. CONCLUSIONS: A Mediterranean diet supplemented with two fatty fish meals per week might be a potential strategy for reducing airway inflammation in childhood asthma. Future robust clinical trials are warranted to replicate and corroborate these findings. SN - 1365-277X UR - https://www.unboundmedicine.com/medline/citation/30378203/Efficacy_of_a_Mediterranean_diet_supplemented_with_fatty_fish_in_ameliorating_inflammation_in_paediatric_asthma:_a_randomised_controlled_trial_ L2 - https://doi.org/10.1111/jhn.12609 DB - PRIME DP - Unbound Medicine ER -