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Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children.
Int J Environ Res Public Health. 2018 10 31; 15(11)IJ

Abstract

Studies have demonstrated that, for urban children, dust represents the main exposure to sources of metals like lead (Pb) and manganese (Mn). We aimed to investigate the exposure to these metals and their association with intellectual deficit in children living in an industrial region. This cross-sectional study recruited volunteers from four elementary schools in the town of Simões Filho, Brazil. We evaluated 225 school-aged children (7⁻12 years) for blood lead (PbB) and manganese hair (MnH) and toenails (MnTn) by graphite furnace atomic absorption spectrometry. Child and maternal IQs were estimated using the Wechsler Abbreviated Scale for Intelligence (WASI). Median and range PbB were 1.2 (0.3⁻15.6) μg/dL. MnH and MnTn medians (ranges) were 0.74 (0.16⁻8.79) μg/g and 0.85 (0.15⁻13.30) μg/g, respectively. After adjusting for maternal IQ, age and Mn exposure, child IQ drops by 8.6 points for a 10-fold increase in PbB levels. Moreover, an effect modification of Mn co-exposure was observed. In children with low MnTn, association between Pb and child IQ was not significant (β = -6.780, p = 0.172). However, in those with high MnTn, the association was increased by 27.9% (β = -8.70, p = 0.036). Low Pb exposure is associated with intellectual deficit in children, especially in those with high MnTn.

Authors+Show Affiliations

Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. antomen@ufba.br.Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. chrissie.carvalho@pro.ucsal.br.Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. julgrodrigues3@gmail.com.Environmental and Public Health Program, National School of Public Health, Oswald Cruz Foundation, Rio de Janeiro 21041-210, Brazil. cecilia.araujo@posgrad.ensp.fiocruz.br.Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. nathalias@ufba.br.Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. cassio.lima@ufba.br.Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. matheus.jesus@ufba.br.Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. lsmbrenoa@gmail.com.Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. anjos.ana@ufba.br.Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. ferreol40@hotmail.com.Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. neander.abreu@ufba.br.Centre de Recherche Interdisciplinaire sur la Biologie, la Santé, la Société et l'Environnement (CINBIOSE), Université du Québec a Montreal, Montreal, QC H3C 3P8, Canada. philibert.aline@uqam.ca.Centre de Recherche Interdisciplinaire sur la Biologie, la Santé, la Société et l'Environnement (CINBIOSE), Université du Québec a Montreal, Montreal, QC H3C 3P8, Canada. mergler.donna@uqam.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30384464

Citation

Menezes-Filho, José A., et al. "Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children." International Journal of Environmental Research and Public Health, vol. 15, no. 11, 2018.
Menezes-Filho JA, Carvalho CF, Rodrigues JLG, et al. Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children. Int J Environ Res Public Health. 2018;15(11).
Menezes-Filho, J. A., Carvalho, C. F., Rodrigues, J. L. G., Araújo, C. F. S., Dos Santos, N. R., Lima, C. S., Bandeira, M. J., Marques, B. L. S., Anjos, A. L. S., Bah, H. A. F., Abreu, N., Philibert, A., & Mergler, D. (2018). Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children. International Journal of Environmental Research and Public Health, 15(11). https://doi.org/10.3390/ijerph15112418
Menezes-Filho JA, et al. Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children. Int J Environ Res Public Health. 2018 10 31;15(11) PubMed PMID: 30384464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children. AU - Menezes-Filho,José A, AU - Carvalho,Chrissie F, AU - Rodrigues,Juliana L G, AU - Araújo,Cecília F S, AU - Dos Santos,Nathália R, AU - Lima,Cássio S, AU - Bandeira,Matheus J, AU - Marques,Breno L de S, AU - Anjos,Ana Laura S, AU - Bah,Homegnon A F, AU - Abreu,Neander, AU - Philibert,Alline, AU - Mergler,Donna, Y1 - 2018/10/31/ PY - 2018/09/30/received PY - 2018/10/21/revised PY - 2018/10/27/accepted PY - 2018/11/3/entrez PY - 2018/11/6/pubmed PY - 2019/2/27/medline KW - children KW - environmental contamination KW - intellectual function KW - lead KW - manganese JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 15 IS - 11 N2 - Studies have demonstrated that, for urban children, dust represents the main exposure to sources of metals like lead (Pb) and manganese (Mn). We aimed to investigate the exposure to these metals and their association with intellectual deficit in children living in an industrial region. This cross-sectional study recruited volunteers from four elementary schools in the town of Simões Filho, Brazil. We evaluated 225 school-aged children (7⁻12 years) for blood lead (PbB) and manganese hair (MnH) and toenails (MnTn) by graphite furnace atomic absorption spectrometry. Child and maternal IQs were estimated using the Wechsler Abbreviated Scale for Intelligence (WASI). Median and range PbB were 1.2 (0.3⁻15.6) μg/dL. MnH and MnTn medians (ranges) were 0.74 (0.16⁻8.79) μg/g and 0.85 (0.15⁻13.30) μg/g, respectively. After adjusting for maternal IQ, age and Mn exposure, child IQ drops by 8.6 points for a 10-fold increase in PbB levels. Moreover, an effect modification of Mn co-exposure was observed. In children with low MnTn, association between Pb and child IQ was not significant (β = -6.780, p = 0.172). However, in those with high MnTn, the association was increased by 27.9% (β = -8.70, p = 0.036). Low Pb exposure is associated with intellectual deficit in children, especially in those with high MnTn. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/30384464/Environmental_Co_Exposure_to_Lead_and_Manganese_and_Intellectual_Deficit_in_School_Aged_Children_ L2 - https://www.mdpi.com/resolver?pii=ijerph15112418 DB - PRIME DP - Unbound Medicine ER -