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Factors associated with freezing of gait in patients with Parkinson's disease.
Neurol Sci. 2019 Feb; 40(2):293-298.NS

Abstract

BACKGROUND

Freezing of gait (FOG) is a common and debilitating problem in patients with Parkinson's disease (PD). The aim of this study was to estimate the prevalence of FOG, and to identify factors that independently contribute to FOG in patients with PD.

METHOD

We included 157 PD patients. FOG was assessed using the FOG Questionnaire (FOG-Q). Patients with or without FOG were defined as item 3 in the FOG-Q.

RESULTS

One hundred eleven (70.7%) out of 157 PD patients presented with FOG. Patients with FOG were older, had long disease duration, were taking higher doses of dopaminergic agents, and had higher motor and non-motor scores than those without FOG. Multivariate linear regression analysis showed that high modified Hoehn and Yahr (mHY) stage, Unified PD Rating Scale (UPDRS) part II score, and non-motor symptom assessment scale for PD (NMSS) total score were significant predictors of a high FOG-Q score. Patients with FOG had significantly higher scores for cardiovascular, gastrointestinal tract, urinary, and miscellaneous NMSS domains than those without FOG.

CONCLUSIONS

FOG in PD was associated with higher mHY stage, UPDRS part II score, and total NMSS score. Therefore, clinicians should consider non-motor, motor features and activities of daily living states for the proper management of FOG.

Authors+Show Affiliations

Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea. National Research Center for Dementia, Gwangju, South Korea. Department of Neurology, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju, 61469, South Korea.Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea.Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea.Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea. byeong.kim7@gmail.com. National Research Center for Dementia, Gwangju, South Korea. byeong.kim7@gmail.com. Department of Neurology, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju, 61469, South Korea. byeong.kim7@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30386934

Citation

Choi, Seong-Min, et al. "Factors Associated With Freezing of Gait in Patients With Parkinson's Disease." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 40, no. 2, 2019, pp. 293-298.
Choi SM, Jung HJ, Yoon GJ, et al. Factors associated with freezing of gait in patients with Parkinson's disease. Neurol Sci. 2019;40(2):293-298.
Choi, S. M., Jung, H. J., Yoon, G. J., & Kim, B. C. (2019). Factors associated with freezing of gait in patients with Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 40(2), 293-298. https://doi.org/10.1007/s10072-018-3625-6
Choi SM, et al. Factors Associated With Freezing of Gait in Patients With Parkinson's Disease. Neurol Sci. 2019;40(2):293-298. PubMed PMID: 30386934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with freezing of gait in patients with Parkinson's disease. AU - Choi,Seong-Min, AU - Jung,Hyun-Jung, AU - Yoon,Geum-Jin, AU - Kim,Byeong C, Y1 - 2018/11/01/ PY - 2018/08/29/received PY - 2018/10/25/accepted PY - 2018/11/6/pubmed PY - 2019/3/12/medline PY - 2018/11/3/entrez KW - Freezing of gait KW - Non-motor symptoms KW - Parkinson’s disease SP - 293 EP - 298 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 40 IS - 2 N2 - BACKGROUND: Freezing of gait (FOG) is a common and debilitating problem in patients with Parkinson's disease (PD). The aim of this study was to estimate the prevalence of FOG, and to identify factors that independently contribute to FOG in patients with PD. METHOD: We included 157 PD patients. FOG was assessed using the FOG Questionnaire (FOG-Q). Patients with or without FOG were defined as item 3 in the FOG-Q. RESULTS: One hundred eleven (70.7%) out of 157 PD patients presented with FOG. Patients with FOG were older, had long disease duration, were taking higher doses of dopaminergic agents, and had higher motor and non-motor scores than those without FOG. Multivariate linear regression analysis showed that high modified Hoehn and Yahr (mHY) stage, Unified PD Rating Scale (UPDRS) part II score, and non-motor symptom assessment scale for PD (NMSS) total score were significant predictors of a high FOG-Q score. Patients with FOG had significantly higher scores for cardiovascular, gastrointestinal tract, urinary, and miscellaneous NMSS domains than those without FOG. CONCLUSIONS: FOG in PD was associated with higher mHY stage, UPDRS part II score, and total NMSS score. Therefore, clinicians should consider non-motor, motor features and activities of daily living states for the proper management of FOG. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/30386934/Factors_associated_with_freezing_of_gait_in_patients_with_Parkinson's_disease_ L2 - https://link.springer.com/10.1007/s10072-018-3625-6 DB - PRIME DP - Unbound Medicine ER -