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Curcumin attenuates nephrotoxicity induced by zinc oxide nanoparticles in rats.
Environ Sci Pollut Res Int. 2019 Jan; 26(1):179-187.ES

Abstract

Curcumin (Cur) effects on renal injury induced by zinc oxide nanoparticles (NZnO) in rats were investigated. NZnO at a dose of 50 mg/kg for 14 days was administered to rats as intoxicated group. In protection group, Cur at a dose of 200 mg/kg was administered for 7 days prior to NZnO treatment and followed by concomitant administration of NZnO for 14 days. Plasma concentrations of uric acid, creatinine (Cr), and blood urea nitrogen (BUN) were detected to evaluate renal injury. Malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels were determined for evaluation oxidative stress. TUNEL staining and histological changes were also performed. Administration of NZnO caused a significant elevation in the uric acid, Cr, and BUN levels. Oxidative stress was increased in the kidney by NZnO through enhancing MDA contents and reducing activities of SOD and GPx enzymes. According to histological examinations, treatment with NZnO caused proximal tubule damages, which was accompanied by the accumulation of red blood cells, infiltration of inflammatory cells, and reducing glomerular diameters. Significant increase was observed in the apoptotic index of the renal tubules in NZnO-treated rats. In present work, pretreatment of Cur reduced the histological changes, decreased biomarker levels, attenuated apoptotic index, and ameliorated oxidative stress by decreasing the MDA contents and increasing the activities of SOD and GPx enzymes. These findings indicate that Cur effectively protects against NZnO-induced nephrotoxicity in the rats.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Heidai-Moghadam A
Student Research committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Khorsandi L
Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. khorsandi_cmrc@yahoo.com.
Jozi Z
Student Research committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

MeSH

AnimalsAntioxidantsBlood Urea NitrogenCreatinineCurcumaCurcuminGlutathione PeroxidaseKidneyKidney DiseasesMaleMalondialdehydeNanoparticlesOxidative StressPhytotherapyPlant ExtractsProtective AgentsRats, WistarSuperoxide DismutaseZinc Oxide

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30387060

Citation

Heidai-Moghadam, Abbas, et al. "Curcumin Attenuates Nephrotoxicity Induced By Zinc Oxide Nanoparticles in Rats." Environmental Science and Pollution Research International, vol. 26, no. 1, 2019, pp. 179-187.
Heidai-Moghadam A, Khorsandi L, Jozi Z. Curcumin attenuates nephrotoxicity induced by zinc oxide nanoparticles in rats. Environ Sci Pollut Res Int. 2019;26(1):179-187.
Heidai-Moghadam, A., Khorsandi, L., & Jozi, Z. (2019). Curcumin attenuates nephrotoxicity induced by zinc oxide nanoparticles in rats. Environmental Science and Pollution Research International, 26(1), 179-187. https://doi.org/10.1007/s11356-018-3514-9
Heidai-Moghadam A, Khorsandi L, Jozi Z. Curcumin Attenuates Nephrotoxicity Induced By Zinc Oxide Nanoparticles in Rats. Environ Sci Pollut Res Int. 2019;26(1):179-187. PubMed PMID: 30387060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin attenuates nephrotoxicity induced by zinc oxide nanoparticles in rats. AU - Heidai-Moghadam,Abbas, AU - Khorsandi,Layasadat, AU - Jozi,Zahra, Y1 - 2018/11/01/ PY - 2018/08/07/received PY - 2018/10/16/accepted PY - 2018/11/6/pubmed PY - 2019/2/15/medline PY - 2018/11/3/entrez KW - Antioxidants KW - Curcumin KW - Nephrotoxicity KW - Oxidative stress KW - Rats KW - Zinc oxide nanoparticles SP - 179 EP - 187 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 1 N2 - Curcumin (Cur) effects on renal injury induced by zinc oxide nanoparticles (NZnO) in rats were investigated. NZnO at a dose of 50 mg/kg for 14 days was administered to rats as intoxicated group. In protection group, Cur at a dose of 200 mg/kg was administered for 7 days prior to NZnO treatment and followed by concomitant administration of NZnO for 14 days. Plasma concentrations of uric acid, creatinine (Cr), and blood urea nitrogen (BUN) were detected to evaluate renal injury. Malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels were determined for evaluation oxidative stress. TUNEL staining and histological changes were also performed. Administration of NZnO caused a significant elevation in the uric acid, Cr, and BUN levels. Oxidative stress was increased in the kidney by NZnO through enhancing MDA contents and reducing activities of SOD and GPx enzymes. According to histological examinations, treatment with NZnO caused proximal tubule damages, which was accompanied by the accumulation of red blood cells, infiltration of inflammatory cells, and reducing glomerular diameters. Significant increase was observed in the apoptotic index of the renal tubules in NZnO-treated rats. In present work, pretreatment of Cur reduced the histological changes, decreased biomarker levels, attenuated apoptotic index, and ameliorated oxidative stress by decreasing the MDA contents and increasing the activities of SOD and GPx enzymes. These findings indicate that Cur effectively protects against NZnO-induced nephrotoxicity in the rats. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/30387060/Curcumin_attenuates_nephrotoxicity_induced_by_zinc_oxide_nanoparticles_in_rats_ DB - PRIME DP - Unbound Medicine ER -