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What is pharmacoepidemiology? Definition, methods, interest and clinical applications.
Therapie. 2019 Apr; 74(2):169-174.T

Abstract

Clinical evaluation of drugs before approval is based on the experimental design of clinical trial with randomization of drug exposure. Unfortunately, conclusions of clinical trials are necessarily limited to patients included into the trials. It is thus necessary to compare these experimental data coming from clinical trials with the real use of drugs in clinical practice. Pharmacoepidemiology is the study of interactions between drugs and human populations, investigating, in real conditions of life, benefits, risks and use of drugs. Pharmacoepidemiology applies to drugs the methods and/or reasoning of both pharmacology and epidemiology. The development of pharmacoepidemiology should improve the "rational drug use".

Authors+Show Affiliations

Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France. Electronic address: jean-louis.montastruc@univ-tlse3.fr.Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30389102

Citation

Montastruc, Jean-Louis, et al. "What Is Pharmacoepidemiology? Definition, Methods, Interest and Clinical Applications." Therapie, vol. 74, no. 2, 2019, pp. 169-174.
Montastruc JL, Benevent J, Montastruc F, et al. What is pharmacoepidemiology? Definition, methods, interest and clinical applications. Therapie. 2019;74(2):169-174.
Montastruc, J. L., Benevent, J., Montastruc, F., Bagheri, H., Despas, F., Lapeyre-Mestre, M., & Sommet, A. (2019). What is pharmacoepidemiology? Definition, methods, interest and clinical applications. Therapie, 74(2), 169-174. https://doi.org/10.1016/j.therap.2018.08.001
Montastruc JL, et al. What Is Pharmacoepidemiology? Definition, Methods, Interest and Clinical Applications. Therapie. 2019;74(2):169-174. PubMed PMID: 30389102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What is pharmacoepidemiology? Definition, methods, interest and clinical applications. AU - Montastruc,Jean-Louis, AU - Benevent,Justine, AU - Montastruc,François, AU - Bagheri,Haleh, AU - Despas,Fabien, AU - Lapeyre-Mestre,Maryse, AU - Sommet,Agnès, Y1 - 2018/10/10/ PY - 2018/05/31/received PY - 2018/08/24/accepted PY - 2018/11/6/pubmed PY - 2019/7/18/medline PY - 2018/11/4/entrez KW - Adverse drug reactions KW - Clinical evaluation KW - Drug risk KW - Drugs KW - Effectiveness KW - Efficacy KW - Pharmacoepidemiology SP - 169 EP - 174 JF - Therapie JO - Therapie VL - 74 IS - 2 N2 - Clinical evaluation of drugs before approval is based on the experimental design of clinical trial with randomization of drug exposure. Unfortunately, conclusions of clinical trials are necessarily limited to patients included into the trials. It is thus necessary to compare these experimental data coming from clinical trials with the real use of drugs in clinical practice. Pharmacoepidemiology is the study of interactions between drugs and human populations, investigating, in real conditions of life, benefits, risks and use of drugs. Pharmacoepidemiology applies to drugs the methods and/or reasoning of both pharmacology and epidemiology. The development of pharmacoepidemiology should improve the "rational drug use". SN - 1958-5578 UR - https://www.unboundmedicine.com/medline/citation/30389102/What_is_pharmacoepidemiology_Definition_methods_interest_and_clinical_applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0040-5957(18)30221-X DB - PRIME DP - Unbound Medicine ER -