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Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques.
J Med Virol. 1987 Jun; 22(2):99-111.JM

Abstract

A nonhuman primate model for Argentine hemorrhagic fever has been developed that closely mimics the human clinical syndrome. Parenteral infection of adult Macaca mulatta with low-passage isolates of two Junin viral strains resulted in distinctive hemorrhagic or neurological disease in rhesus macaques that correlated with clinical illness patterns present in the humans from whom the viral strains were obtained. Transient leukopenia, together with thrombocytopenia and secondary bacterial septicemia, were documented among animals infected with both viral strains. In contrast, differing patterns of viremia, oropharyngeal viral shedding, and antibody response occurred in the two virus-infected groups. These results, together with postmortem virologic and histopathologic findings, suggest that viral-strain-specific factors are important determinants of clinical disease patterns in this model system.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3039054

Citation

McKee, K T., et al. "Virus-specific Factors in Experimental Argentine Hemorrhagic Fever in Rhesus Macaques." Journal of Medical Virology, vol. 22, no. 2, 1987, pp. 99-111.
McKee KT, Mahlandt BG, Maiztegui JI, et al. Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. J Med Virol. 1987;22(2):99-111.
McKee, K. T., Mahlandt, B. G., Maiztegui, J. I., Green, D. E., & Peters, C. J. (1987). Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. Journal of Medical Virology, 22(2), 99-111.
McKee KT, et al. Virus-specific Factors in Experimental Argentine Hemorrhagic Fever in Rhesus Macaques. J Med Virol. 1987;22(2):99-111. PubMed PMID: 3039054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. AU - McKee,K T,Jr AU - Mahlandt,B G, AU - Maiztegui,J I, AU - Green,D E, AU - Peters,C J, PY - 1987/6/1/pubmed PY - 2001/3/28/medline PY - 1987/6/1/entrez SP - 99 EP - 111 JF - Journal of medical virology JO - J Med Virol VL - 22 IS - 2 N2 - A nonhuman primate model for Argentine hemorrhagic fever has been developed that closely mimics the human clinical syndrome. Parenteral infection of adult Macaca mulatta with low-passage isolates of two Junin viral strains resulted in distinctive hemorrhagic or neurological disease in rhesus macaques that correlated with clinical illness patterns present in the humans from whom the viral strains were obtained. Transient leukopenia, together with thrombocytopenia and secondary bacterial septicemia, were documented among animals infected with both viral strains. In contrast, differing patterns of viremia, oropharyngeal viral shedding, and antibody response occurred in the two virus-infected groups. These results, together with postmortem virologic and histopathologic findings, suggest that viral-strain-specific factors are important determinants of clinical disease patterns in this model system. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/3039054/Virus_specific_factors_in_experimental_Argentine_hemorrhagic_fever_in_rhesus_macaques_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1987&volume=22&issue=2&spage=99 DB - PRIME DP - Unbound Medicine ER -