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Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India.
Int J Infect Dis. 2019 Feb; 79:195-198.IJ

Abstract

BACKGROUND

The aim of this study was to estimate the seroprevalence of spotted fever group (SFG) and typhus group (TG) rickettsiae among individuals with acute febrile illness (AFI) in the scrub typhus endemic district of Gorakhpur in India. This district is one of the worst affected by annual seasonal acute encephalitis syndrome (AES) outbreaks.

METHODS

Antibodies against SFG and TG rickettsiae and the associated risk factors were determined in 294 individuals presenting with an AFI, encountered during a community-based survey conducted during the AES outbreak period October-November 2016.

RESULTS

Respective IgM and IgG seropositivity was 13.6% and 36.7% for SFG, and 7.1% and 15.3% for TG. SFG IgM positivity was significantly higher among females, while IgG positivity was significantly higher among individuals ≥45 years of age. IgM and IgG seropositivity for TG rickettsiae were significantly higher in individuals involved in outdoor activities and housewives, but did not differ according to age group, sex, or educational status.

CONCLUSION

The study results present serological evidence of SFG and TG rickettsiosis, in addition to scrub typhus, among individuals with AFI in Gorakhpur region and indicate the need to explore their roles as potential causes of AES in the region.

Authors+Show Affiliations

ICMR - National AIDS Research Institute, Pune, Maharashtra, India. Electronic address: amane@nariindia.org.ICMR - National AIDS Research Institute, Pune, Maharashtra, India.Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India.ICMR - National AIDS Research Institute, Pune, Maharashtra, India.ICMR - National AIDS Research Institute, Pune, Maharashtra, India.Indian Council of Medical Research, New Delhi, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30391326

Citation

Mane, Arati, et al. "Seroprevalence of Spotted Fever Group and Typhus Group Rickettsiae in Individuals With Acute Febrile Illness From Gorakhpur, India." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 79, 2019, pp. 195-198.
Mane A, Kamble S, Singh MK, et al. Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India. Int J Infect Dis. 2019;79:195-198.
Mane, A., Kamble, S., Singh, M. K., Ratnaparakhi, M., Nirmalkar, A., & Gangakhedkar, R. (2019). Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 79, 195-198. https://doi.org/10.1016/j.ijid.2018.10.024
Mane A, et al. Seroprevalence of Spotted Fever Group and Typhus Group Rickettsiae in Individuals With Acute Febrile Illness From Gorakhpur, India. Int J Infect Dis. 2019;79:195-198. PubMed PMID: 30391326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India. AU - Mane,Arati, AU - Kamble,Suchit, AU - Singh,Manish Kumar, AU - Ratnaparakhi,Manisha, AU - Nirmalkar,Amit, AU - Gangakhedkar,Raman, Y1 - 2018/11/02/ PY - 2018/08/23/received PY - 2018/10/08/revised PY - 2018/10/12/accepted PY - 2018/11/6/pubmed PY - 2019/4/30/medline PY - 2018/11/5/entrez KW - Gorakhpur KW - Indian tick typhus KW - Murine typhus KW - Rickettsia conorii KW - Rickettsia typhi KW - Spotted fever group rickettsiae KW - Typhus group rickettsiae SP - 195 EP - 198 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int. J. Infect. Dis. VL - 79 N2 - BACKGROUND: The aim of this study was to estimate the seroprevalence of spotted fever group (SFG) and typhus group (TG) rickettsiae among individuals with acute febrile illness (AFI) in the scrub typhus endemic district of Gorakhpur in India. This district is one of the worst affected by annual seasonal acute encephalitis syndrome (AES) outbreaks. METHODS: Antibodies against SFG and TG rickettsiae and the associated risk factors were determined in 294 individuals presenting with an AFI, encountered during a community-based survey conducted during the AES outbreak period October-November 2016. RESULTS: Respective IgM and IgG seropositivity was 13.6% and 36.7% for SFG, and 7.1% and 15.3% for TG. SFG IgM positivity was significantly higher among females, while IgG positivity was significantly higher among individuals ≥45 years of age. IgM and IgG seropositivity for TG rickettsiae were significantly higher in individuals involved in outdoor activities and housewives, but did not differ according to age group, sex, or educational status. CONCLUSION: The study results present serological evidence of SFG and TG rickettsiosis, in addition to scrub typhus, among individuals with AFI in Gorakhpur region and indicate the need to explore their roles as potential causes of AES in the region. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/30391326/Seroprevalence_of_spotted_fever_group_and_typhus_group_rickettsiae_in_individuals_with_acute_febrile_illness_from_Gorakhpur_India_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(18)34572-7 DB - PRIME DP - Unbound Medicine ER -