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Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study.
Arch Oral Biol. 2019 Jan; 97:170-175.AO

Abstract

OBJECTIVE

The objective was to investigate dental phenotypes in individuals with non-syndromic Pierre Robin Sequence (ns-PRS) and compare the prevalence of these phenotypes with subjects with non-syndromic cleft palate (ns-CP) and a control group with subjects without any craniofacial anomalies.

METHODS

A total of 760 panoramic radiographs of 330 individuals (110 with ns-PRS; 110 with ns-CP and 110 without any malformations) were digitized and evaluated regarding the diagnosis of taurodontism, tooth agenesis, root dilaceration and tooth transposition. Chi-square test was applied to compare the occurrence of dental phenotypes between groups. A P value of less than 0.05 was considered statistically significant.

RESULTS

Total prevalence of dental phenotypes was 94.5% of ns-PRS; 54.5% of ns-CP and 59.1% of the control group subjects with a statistically significant difference for the ns-PRS when compared to the other two groups. Two dental phenotypes, taurodontism and dental agenesis were identified with statistically significant higher prevalences in subjects with ns-PRS when compared with the ns-CP group and the control group (p < 0.001). Taurodontism was the most prevalent dental phenotype, with 92.73% in the ns-PRS group, 40.91% for ns-CP and 44.55% in the control group. Tooth agenesis had a prevalence of 22.7% for ns-PRS, 4.5% for ns-CP and no case in the control group. For the prevalence of root dilaceration and tooth transposition, no statistically significant differences were observed between the three groups.

CONCLUSIONS

Due to the high frequency of taurodontism in individuals with ns-PRS, we suggested that this novel phenotype would be important in the phenotypic screening of ns-PRS and could be considered as a phenotype associated with ns-PRS.

Authors+Show Affiliations

Post-Graduation Program in Rehabilitation Sciences, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Brazil.Oral Diagnosis Section - Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Brazil.Oral Diagnosis Section - Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Brazil.Post-Graduation Program in Rehabilitation Sciences, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Brazil.Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Post-Graduation Program in Rehabilitation Sciences, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Brazil. Electronic address: lucimaraneves@fob.usp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30391793

Citation

Mateo-Castillo, Jose Francisco, et al. "Novel Dental Phenotype in Non-syndromic Pierre Robin Sequence: a Retrospective Study." Archives of Oral Biology, vol. 97, 2019, pp. 170-175.
Mateo-Castillo JF, Pagin O, Marchi Carvalho IM, et al. Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study. Arch Oral Biol. 2019;97:170-175.
Mateo-Castillo, J. F., Pagin, O., Marchi Carvalho, I. M., Olano-Dextre, T. L., & Teixeira das Neves, L. (2019). Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study. Archives of Oral Biology, 97, 170-175. https://doi.org/10.1016/j.archoralbio.2018.10.031
Mateo-Castillo JF, et al. Novel Dental Phenotype in Non-syndromic Pierre Robin Sequence: a Retrospective Study. Arch Oral Biol. 2019;97:170-175. PubMed PMID: 30391793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study. AU - Mateo-Castillo,Jose Francisco, AU - Pagin,Otavio, AU - Marchi Carvalho,Izabel Maria, AU - Olano-Dextre,Tulio Lorenzo, AU - Teixeira das Neves,Lucimara, Y1 - 2018/10/29/ PY - 2018/03/15/received PY - 2018/10/09/revised PY - 2018/10/26/accepted PY - 2018/11/6/pubmed PY - 2019/4/20/medline PY - 2018/11/5/entrez KW - Cleft palate KW - Dental diseases KW - Developmental disorders KW - Pierre Robin Sequence KW - Taurodontism KW - Tooth abnormalities SP - 170 EP - 175 JF - Archives of oral biology JO - Arch. Oral Biol. VL - 97 N2 - OBJECTIVE: The objective was to investigate dental phenotypes in individuals with non-syndromic Pierre Robin Sequence (ns-PRS) and compare the prevalence of these phenotypes with subjects with non-syndromic cleft palate (ns-CP) and a control group with subjects without any craniofacial anomalies. METHODS: A total of 760 panoramic radiographs of 330 individuals (110 with ns-PRS; 110 with ns-CP and 110 without any malformations) were digitized and evaluated regarding the diagnosis of taurodontism, tooth agenesis, root dilaceration and tooth transposition. Chi-square test was applied to compare the occurrence of dental phenotypes between groups. A P value of less than 0.05 was considered statistically significant. RESULTS: Total prevalence of dental phenotypes was 94.5% of ns-PRS; 54.5% of ns-CP and 59.1% of the control group subjects with a statistically significant difference for the ns-PRS when compared to the other two groups. Two dental phenotypes, taurodontism and dental agenesis were identified with statistically significant higher prevalences in subjects with ns-PRS when compared with the ns-CP group and the control group (p < 0.001). Taurodontism was the most prevalent dental phenotype, with 92.73% in the ns-PRS group, 40.91% for ns-CP and 44.55% in the control group. Tooth agenesis had a prevalence of 22.7% for ns-PRS, 4.5% for ns-CP and no case in the control group. For the prevalence of root dilaceration and tooth transposition, no statistically significant differences were observed between the three groups. CONCLUSIONS: Due to the high frequency of taurodontism in individuals with ns-PRS, we suggested that this novel phenotype would be important in the phenotypic screening of ns-PRS and could be considered as a phenotype associated with ns-PRS. SN - 1879-1506 UR - https://www.unboundmedicine.com/medline/citation/30391793/Novel_dental_phenotype_in_non_syndromic_Pierre_Robin_Sequence:_A_retrospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(18)30734-9 DB - PRIME DP - Unbound Medicine ER -