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[Production of H2S, H2Sn, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase].
Nihon Yakurigaku Zasshi. 2018; 152(5):216-222.NY

Abstract

Accumulating evidence shows that hydrogen sulfide (H2S) has physiological roles in various tissues and organs, including the regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced from l-cysteine by pyridoxal 5'-phosphate (PLP)-dependent enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). 3-Mercaptopyruvate sulfurtransferase (3MST) is the third H2S-producing enzyme, and its substrate 3-mercaptopyruvate (3MP) is provided from l-cysteine and α-ketoglutarate (α-KG) by a PLP-dependent cysteine aminotransferase (CAT). An additional pathway for the production of H2S from d-cysteine metabolized by d-amino acid oxidase (DAO) together with 3MST has been identified. Recent studies have shown that hydrogen polysulfides (H2Sn) have been found to stimulate transient receptor potential ankyrin1 (TRPA1) channel, much more potently than does H2S. 3MST produces cysteine-persulfide (CysSSH) and its glutathione counterpart (GSSH), potential redox regulators, together with the potential signaling molecules H2Sn. In addition, the interaction between H2S and nitric oxide (NO) also generates H2Sn. These observations provide new insights into the production and physiological roles of these molecules.

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Authors+Show Affiliations

Shibuya N
National Institute of Neuroscience, National Center of Neurology and Psychiatry.

MeSH

Cystathionine beta-SynthaseCystathionine gamma-LyaseCysteineHumansHydrogen SulfideSulfidesSulfurtransferases

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

30393252

Citation

Shibuya, Norihiro. "[Production of H2S, H2Sn, and Persulfide Species (CysSSH and GSSH) By 3-mercaptopyruvate Sulfurtransferase]." Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica, vol. 152, no. 5, 2018, pp. 216-222.
Shibuya N. [Production of H2S, H2Sn, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase]. Nihon Yakurigaku Zasshi. 2018;152(5):216-222.
Shibuya, N. (2018). [Production of H2S, H2Sn, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica, 152(5), 216-222. https://doi.org/10.1254/fpj.152.216
Shibuya N. [Production of H2S, H2Sn, and Persulfide Species (CysSSH and GSSH) By 3-mercaptopyruvate Sulfurtransferase]. Nihon Yakurigaku Zasshi. 2018;152(5):216-222. PubMed PMID: 30393252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Production of H2S, H2Sn, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase]. A1 - Shibuya,Norihiro, PY - 2018/11/6/entrez PY - 2018/11/6/pubmed PY - 2019/6/14/medline SP - 216 EP - 222 JF - Nihon yakurigaku zasshi. Folia pharmacologica Japonica JO - Nihon Yakurigaku Zasshi VL - 152 IS - 5 N2 - Accumulating evidence shows that hydrogen sulfide (H2S) has physiological roles in various tissues and organs, including the regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced from l-cysteine by pyridoxal 5'-phosphate (PLP)-dependent enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). 3-Mercaptopyruvate sulfurtransferase (3MST) is the third H2S-producing enzyme, and its substrate 3-mercaptopyruvate (3MP) is provided from l-cysteine and α-ketoglutarate (α-KG) by a PLP-dependent cysteine aminotransferase (CAT). An additional pathway for the production of H2S from d-cysteine metabolized by d-amino acid oxidase (DAO) together with 3MST has been identified. Recent studies have shown that hydrogen polysulfides (H2Sn) have been found to stimulate transient receptor potential ankyrin1 (TRPA1) channel, much more potently than does H2S. 3MST produces cysteine-persulfide (CysSSH) and its glutathione counterpart (GSSH), potential redox regulators, together with the potential signaling molecules H2Sn. In addition, the interaction between H2S and nitric oxide (NO) also generates H2Sn. These observations provide new insights into the production and physiological roles of these molecules. SN - 0015-5691 UR - https://www.unboundmedicine.com/medline/citation/30393252/[Production_of_H2S_H2Sn_and_persulfide_species__CysSSH_and_GSSH__by_3_mercaptopyruvate_sulfurtransferase]_ L2 - https://dx.doi.org/10.1254/fpj.152.216 DB - PRIME DP - Unbound Medicine ER -