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A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases.
CNS Neurol Disord Drug Targets. 2019; 18(2):103-114.CN

Abstract

BACKGROUND & OBJECTIVE

Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms.

CONCLUSION

This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhao J
Department of Chinese Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
Zhu M
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
Kumar M
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
Ngo FY
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
Li Y
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
Lao L
Department of Chinese Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
Rong J
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. Institute of Research and Innovation (HKU-SIRI), The University of Hong Kong Shenzhen, Shenzhen, China.

MeSH

Alzheimer DiseaseAnimalsFlavonoidsHumansNeurodegenerative DiseasesNeuroprotectionNeuroprotective AgentsParkinson Disease

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30394219

Citation

Zhao, Jia, et al. "A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases." CNS & Neurological Disorders Drug Targets, vol. 18, no. 2, 2019, pp. 103-114.
Zhao J, Zhu M, Kumar M, et al. A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases. CNS Neurol Disord Drug Targets. 2019;18(2):103-114.
Zhao, J., Zhu, M., Kumar, M., Ngo, F. Y., Li, Y., Lao, L., & Rong, J. (2019). A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases. CNS & Neurological Disorders Drug Targets, 18(2), 103-114. https://doi.org/10.2174/1871527317666181105093834
Zhao J, et al. A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases. CNS Neurol Disord Drug Targets. 2019;18(2):103-114. PubMed PMID: 30394219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases. AU - Zhao,Jia, AU - Zhu,Mengxia, AU - Kumar,Mukesh, AU - Ngo,Fung Yin, AU - Li,Yinghui, AU - Lao,Lixing, AU - Rong,Jianhui, PY - 2018/09/08/received PY - 2018/10/22/revised PY - 2018/10/29/accepted PY - 2018/11/6/pubmed PY - 2020/5/14/medline PY - 2018/11/6/entrez KW - Neurodegenerative diseases KW - flavonoids KW - neuroprotective KW - neurorestorative KW - pathogenesis KW - pharmacological appraisal. SP - 103 EP - 114 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 18 IS - 2 N2 - BACKGROUND & OBJECTIVE: Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms. CONCLUSION: This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/30394219/A_Pharmacological_Appraisal_of_Neuroprotective_and_Neurorestorative_Flavonoids_Against_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -