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Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches.
Int J Pharm. 2019 Jan 10; 554:116-124.IJ

Abstract

Tablet final properties are mainly determined during the compaction process by the evolution of the stresses applied to the powder. Any process or product parameter that may influence this stress evolution may have a direct impact on the tablet final properties. In this article, we studied the influence of the friction between the tooling and the powder on the evolution of the die-wall pressure during compaction using flat and concave punches. Experimental studies were performed on microcrystalline cellulose as well as numerical studies using finite element method (FEM) simulation. Both methodologies indicate that increasing the friction between the powder and the tooling promotes an increase in the die-wall pressure during tableting. This is in contradiction with results that can be found in the literature. Moreover, the results of this study showed that for flat punches, the stress evolution is mainly driven by the die/powder friction. On the contrary, for concave punches, changing the punches/powder friction have also a consequence in the evolution of the die-wall pressure. This could have practical consequences in sticking situations where, due film formation on the punches, the friction between the punches and the powder may change during tableting.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mazel V
Université de Bordeaux, CNRS, I2M Bordeaux, 146 rue Léo Saignat, 33000 Bordeaux, France. Electronic address: vincent.mazel@u-bordeaux.fr.
Diarra H
Université de Bordeaux, CNRS, I2M Bordeaux, 146 rue Léo Saignat, 33000 Bordeaux, France.
Tchoreloff P
Université de Bordeaux, CNRS, I2M Bordeaux, 146 rue Léo Saignat, 33000 Bordeaux, France.

MeSH

CelluloseChemistry, PharmaceuticalDrug CompoundingExcipientsFinite Element AnalysisFrictionPowdersPressureTabletsTechnology, Pharmaceutical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30395955

Citation

Mazel, V, et al. "Effect of Friction Between Powder and Tooling On the Die-wall Pressure Evolution During Tableting: Experimental and Numerical Results for Flat and Concave Punches." International Journal of Pharmaceutics, vol. 554, 2019, pp. 116-124.
Mazel V, Diarra H, Tchoreloff P. Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches. Int J Pharm. 2019;554:116-124.
Mazel, V., Diarra, H., & Tchoreloff, P. (2019). Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches. International Journal of Pharmaceutics, 554, 116-124. https://doi.org/10.1016/j.ijpharm.2018.11.003
Mazel V, Diarra H, Tchoreloff P. Effect of Friction Between Powder and Tooling On the Die-wall Pressure Evolution During Tableting: Experimental and Numerical Results for Flat and Concave Punches. Int J Pharm. 2019 Jan 10;554:116-124. PubMed PMID: 30395955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches. AU - Mazel,V, AU - Diarra,H, AU - Tchoreloff,P, Y1 - 2018/11/02/ PY - 2018/09/12/received PY - 2018/10/30/revised PY - 2018/11/01/accepted PY - 2018/11/6/pubmed PY - 2019/4/4/medline PY - 2018/11/6/entrez KW - Die-wall pressure KW - FEM KW - Friction KW - Sticking KW - Tableting SP - 116 EP - 124 JF - International journal of pharmaceutics JO - Int J Pharm VL - 554 N2 - Tablet final properties are mainly determined during the compaction process by the evolution of the stresses applied to the powder. Any process or product parameter that may influence this stress evolution may have a direct impact on the tablet final properties. In this article, we studied the influence of the friction between the tooling and the powder on the evolution of the die-wall pressure during compaction using flat and concave punches. Experimental studies were performed on microcrystalline cellulose as well as numerical studies using finite element method (FEM) simulation. Both methodologies indicate that increasing the friction between the powder and the tooling promotes an increase in the die-wall pressure during tableting. This is in contradiction with results that can be found in the literature. Moreover, the results of this study showed that for flat punches, the stress evolution is mainly driven by the die/powder friction. On the contrary, for concave punches, changing the punches/powder friction have also a consequence in the evolution of the die-wall pressure. This could have practical consequences in sticking situations where, due film formation on the punches, the friction between the punches and the powder may change during tableting. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/30395955/Effect_of_friction_between_powder_and_tooling_on_the_die_wall_pressure_evolution_during_tableting:_Experimental_and_numerical_results_for_flat_and_concave_punches_ DB - PRIME DP - Unbound Medicine ER -