Tags

Type your tag names separated by a space and hit enter

Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain.
Curr Pharm Biotechnol. 2018; 19(11):848-855.CP

Abstract

Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain. The majority of the research has been focused on Nav1.7 in particular, other VGSC subtypes, such as Nav1.1, Nav1.3, Nav1.6, Nav1.8 and Nav1.9 have recently come to the forefront of analgesic research. Peptides from scorpion have been proved to be a valuable tool in neuroscience, playing a significant role in the identification and characterization of VGSC subtypes and many of them resulting in analgesia in pain. This review assesses the potential of scorpion toxin targeting VGSCs for analgesic development.

Authors+Show Affiliations

School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, 110004, CN, China.College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, CN, China.School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30398114

Citation

Xu, Yijia, et al. "Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated With Pain." Current Pharmaceutical Biotechnology, vol. 19, no. 11, 2018, pp. 848-855.
Xu Y, Sun J, Liu H, et al. Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain. Curr Pharm Biotechnol. 2018;19(11):848-855.
Xu, Y., Sun, J., Liu, H., Sun, J., Yu, Y., Su, Y., Cui, Y., Zhao, M., & Zhang, J. (2018). Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain. Current Pharmaceutical Biotechnology, 19(11), 848-855. https://doi.org/10.2174/1389201019666181105160744
Xu Y, et al. Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated With Pain. Curr Pharm Biotechnol. 2018;19(11):848-855. PubMed PMID: 30398114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain. AU - Xu,Yijia, AU - Sun,Junxin, AU - Liu,Hongyu, AU - Sun,Jianfang, AU - Yu,Yue, AU - Su,Yang, AU - Cui,Yong, AU - Zhao,Mingyi, AU - Zhang,Jinghai, PY - 2018/09/20/received PY - 2018/10/23/revised PY - 2018/10/24/accepted PY - 2018/11/7/pubmed PY - 2019/3/12/medline PY - 2018/11/7/entrez KW - NSAIDs KW - Pain KW - VGSC KW - autoimmune diseases KW - peptide KW - scorpion toxin. SP - 848 EP - 855 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 19 IS - 11 N2 - Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain. The majority of the research has been focused on Nav1.7 in particular, other VGSC subtypes, such as Nav1.1, Nav1.3, Nav1.6, Nav1.8 and Nav1.9 have recently come to the forefront of analgesic research. Peptides from scorpion have been proved to be a valuable tool in neuroscience, playing a significant role in the identification and characterization of VGSC subtypes and many of them resulting in analgesia in pain. This review assesses the potential of scorpion toxin targeting VGSCs for analgesic development. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/30398114/Scorpion_Toxins_Targeting_Voltage_gated_Sodium_Channels_Associated_with_Pain_ L2 - http://www.eurekaselect.com/167056/article DB - PRIME DP - Unbound Medicine ER -