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Preeclampsia: A close look at renal dysfunction.
Biomed Pharmacother 2019; 109:408-416BP

Abstract

Preeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic factors originated from hypoxic placenta. It is simply defined by the new onset of hypertension (≥140/90 mmHg) and proteinuria (≥0.3 g/day) after 20 weeks of gestation. PE is associated with kidney dysfunction due to deficiency in podocyte specific vascular endothelial growth factor (VEGF). Hypoxic placenta in PE patients produces increased levels of fms-like tyrosine kinase 1(sFlt-1), a soluble receptor of VEGF. sFlt-1 abrogates binding of VEGF to its receptor on endothelial cells and podocytes, and ultimately damages the filtration barrier. Glomerular endotheliosis and thrombotic microangiopathy (TMA) are the main features of kidney involvement in PE and can induce clotting and vessel occlusion. This complex pathophysiology is ameliorated after delivery; however, permanent kidney damages may remain and is intensified thereafter. This review aims to highlight the biochemical, genetic, and immunological-involved factors in the initiation of PE and explores the relationship between the kidney and PE. This work mainly discusses the pathologic mechanisms of kidney involvement in PE through the lens of the imbalanced VEGF-VEGF receptor signaling pathway.

Authors+Show Affiliations

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: ardalan34@yahoo.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30399576

Citation

Moghaddas Sani, Hakimeh, et al. "Preeclampsia: a Close Look at Renal Dysfunction." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 109, 2019, pp. 408-416.
Moghaddas Sani H, Zununi Vahed S, Ardalan M. Preeclampsia: A close look at renal dysfunction. Biomed Pharmacother. 2019;109:408-416.
Moghaddas Sani, H., Zununi Vahed, S., & Ardalan, M. (2019). Preeclampsia: A close look at renal dysfunction. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 109, pp. 408-416. doi:10.1016/j.biopha.2018.10.082.
Moghaddas Sani H, Zununi Vahed S, Ardalan M. Preeclampsia: a Close Look at Renal Dysfunction. Biomed Pharmacother. 2019;109:408-416. PubMed PMID: 30399576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preeclampsia: A close look at renal dysfunction. AU - Moghaddas Sani,Hakimeh, AU - Zununi Vahed,Sepideh, AU - Ardalan,Mohammadreza, Y1 - 2018/11/03/ PY - 2018/07/02/received PY - 2018/10/06/revised PY - 2018/10/14/accepted PY - 2018/11/7/pubmed PY - 2019/3/26/medline PY - 2018/11/7/entrez KW - Glomerular endotheliosis KW - Hypertension KW - Placenta KW - Podocytopathy KW - Proteinuria KW - Renal dysfunction SP - 408 EP - 416 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed. Pharmacother. VL - 109 N2 - Preeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic factors originated from hypoxic placenta. It is simply defined by the new onset of hypertension (≥140/90 mmHg) and proteinuria (≥0.3 g/day) after 20 weeks of gestation. PE is associated with kidney dysfunction due to deficiency in podocyte specific vascular endothelial growth factor (VEGF). Hypoxic placenta in PE patients produces increased levels of fms-like tyrosine kinase 1(sFlt-1), a soluble receptor of VEGF. sFlt-1 abrogates binding of VEGF to its receptor on endothelial cells and podocytes, and ultimately damages the filtration barrier. Glomerular endotheliosis and thrombotic microangiopathy (TMA) are the main features of kidney involvement in PE and can induce clotting and vessel occlusion. This complex pathophysiology is ameliorated after delivery; however, permanent kidney damages may remain and is intensified thereafter. This review aims to highlight the biochemical, genetic, and immunological-involved factors in the initiation of PE and explores the relationship between the kidney and PE. This work mainly discusses the pathologic mechanisms of kidney involvement in PE through the lens of the imbalanced VEGF-VEGF receptor signaling pathway. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/30399576/Preeclampsia:_A_close_look_at_renal_dysfunction L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(18)34492-5 DB - PRIME DP - Unbound Medicine ER -