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New Metabolites from Endophytic Fungus Chaetomium globosum CDW7.
Molecules. 2018 Nov 04; 23(11)M

Abstract

Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3⁻5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%).

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Authors+Show Affiliations

Yan W
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. yanwei@njau.edu.cn. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. yanwei@njau.edu.cn.
Cao LL
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. 2015202050@njau.edu.cn. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. 2015202050@njau.edu.cn.
Zhang YY
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. zyy2857@163.com. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. zyy2857@163.com.
Zhao R
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. 2017102130@njau.edu.cn. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. 2017102130@njau.edu.cn.
Zhao SS
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. 2017202055@njau.edu.cn. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. 2017202055@njau.edu.cn.
Khan B
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. babarkhan.uaf@gmail.com. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. babarkhan.uaf@gmail.com.
Ye YH
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. yeyh@njau.edu.cn. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. yeyh@njau.edu.cn.

MeSH

AlkaloidsAntifungal AgentsAscomycotaChaetomiumCircular DichroismIndole AlkaloidsMagnetic Resonance SpectroscopySpectrometry, Mass, Electrospray Ionization

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30400338

Citation

Yan, Wei, et al. "New Metabolites From Endophytic Fungus Chaetomium Globosum CDW7." Molecules (Basel, Switzerland), vol. 23, no. 11, 2018.
Yan W, Cao LL, Zhang YY, et al. New Metabolites from Endophytic Fungus Chaetomium globosum CDW7. Molecules. 2018;23(11).
Yan, W., Cao, L. L., Zhang, Y. Y., Zhao, R., Zhao, S. S., Khan, B., & Ye, Y. H. (2018). New Metabolites from Endophytic Fungus Chaetomium globosum CDW7. Molecules (Basel, Switzerland), 23(11). https://doi.org/10.3390/molecules23112873
Yan W, et al. New Metabolites From Endophytic Fungus Chaetomium Globosum CDW7. Molecules. 2018 Nov 4;23(11) PubMed PMID: 30400338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New Metabolites from Endophytic Fungus Chaetomium globosum CDW7. AU - Yan,Wei, AU - Cao,Ling-Ling, AU - Zhang,Yang-Yang, AU - Zhao,Ran, AU - Zhao,Shuang-Shuang, AU - Khan,Babar, AU - Ye,Yong-Hao, Y1 - 2018/11/04/ PY - 2018/10/10/received PY - 2018/10/26/revised PY - 2018/11/01/accepted PY - 2018/11/8/entrez PY - 2018/11/8/pubmed PY - 2019/2/5/medline KW - Chaetomium globosum KW - antifungal activity KW - indole alkaloid KW - isocoumarin derivatives JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 11 N2 - Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3⁻5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%). SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/30400338/New_Metabolites_from_Endophytic_Fungus_Chaetomium_globosum_CDW7_ DB - PRIME DP - Unbound Medicine ER -