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Vitamin E intake and risk of stroke: a meta-analysis.
Br J Nutr 2018; 120(10):1181-1188BJ

Abstract

Findings from observational studies on the associations between vitamin E intake and stroke risk remain controversial, and the dose-response relationship between vitamin E intake and risk of stroke remains to be determined. We conducted a meta-analysis of prospective studies aiming to clarify the relationships between vitamin E intake and risk of stroke. Relevant studies were identified by searching online databases through to June 2018. We computed summary relative risks (RR) with corresponding 95 % CI. Among 3156 articles retrieved from online databases and relevant bibliographies, nine studies involving 3284 events and 220 371 participants were included in the final analyses. High dietary vitamin E intake was inversely associated with the risk of overall stroke (RR=0·83, 95 % CI 0·73, 0·94), and with the risk of stroke for individuals who were followed-up for <10 (RR=0·84, 95 % CI 0·72, 0·91). There was a non-linear association between dietary vitamin E intake and stroke risk (P=0·0249). Omission of any single study did not alter the summary result. In conclusion, this meta-analysis suggests that there is a significant inverse relationship between dietary vitamin E intake and stroke risk. This meta-analysis provides evidence that a higher dietary vitamin E intake is associated with a lower stroke risk.

Authors+Show Affiliations

1Department of Neurology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.1Department of Neurology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.1Department of Neurology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.2Department of Histology and Embryology,School of Basic Medical Sciences,Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.1Department of Neurology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.3Department of Cardiology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.1Department of Neurology,The First Affiliated Hospital of Jiamusi University,154002 Jiamusi,Heilongjiang Province,People's Republic of China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30401005

Citation

Cheng, Pengfei, et al. "Vitamin E Intake and Risk of Stroke: a Meta-analysis." The British Journal of Nutrition, vol. 120, no. 10, 2018, pp. 1181-1188.
Cheng P, Wang L, Ning S, et al. Vitamin E intake and risk of stroke: a meta-analysis. Br J Nutr. 2018;120(10):1181-1188.
Cheng, P., Wang, L., Ning, S., Liu, Z., Lin, H., Chen, S., & Zhu, J. (2018). Vitamin E intake and risk of stroke: a meta-analysis. The British Journal of Nutrition, 120(10), pp. 1181-1188. doi:10.1017/S0007114518002647.
Cheng P, et al. Vitamin E Intake and Risk of Stroke: a Meta-analysis. Br J Nutr. 2018;120(10):1181-1188. PubMed PMID: 30401005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E intake and risk of stroke: a meta-analysis. AU - Cheng,Pengfei, AU - Wang,Lihua, AU - Ning,Shujun, AU - Liu,Zichun, AU - Lin,Hao, AU - Chen,Shuli, AU - Zhu,Jiaying, PY - 2018/11/8/entrez PY - 2018/11/8/pubmed PY - 2019/9/10/medline KW - RCT KW - RR KW - randomised controlled trial KW - relative risk KW - Dose–response relationships KW - Meta-analyses KW - Stroke risk KW - Vitamin E intake SP - 1181 EP - 1188 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 120 IS - 10 N2 - Findings from observational studies on the associations between vitamin E intake and stroke risk remain controversial, and the dose-response relationship between vitamin E intake and risk of stroke remains to be determined. We conducted a meta-analysis of prospective studies aiming to clarify the relationships between vitamin E intake and risk of stroke. Relevant studies were identified by searching online databases through to June 2018. We computed summary relative risks (RR) with corresponding 95 % CI. Among 3156 articles retrieved from online databases and relevant bibliographies, nine studies involving 3284 events and 220 371 participants were included in the final analyses. High dietary vitamin E intake was inversely associated with the risk of overall stroke (RR=0·83, 95 % CI 0·73, 0·94), and with the risk of stroke for individuals who were followed-up for <10 (RR=0·84, 95 % CI 0·72, 0·91). There was a non-linear association between dietary vitamin E intake and stroke risk (P=0·0249). Omission of any single study did not alter the summary result. In conclusion, this meta-analysis suggests that there is a significant inverse relationship between dietary vitamin E intake and stroke risk. This meta-analysis provides evidence that a higher dietary vitamin E intake is associated with a lower stroke risk. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/30401005/Vitamin_E_intake_and_risk_of_stroke:_a_meta_analysis_ L2 - https://www.cambridge.org/core/product/identifier/S0007114518002647/type/journal_article DB - PRIME DP - Unbound Medicine ER -