Tags

Type your tag names separated by a space and hit enter

Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells.
Evid Based Complement Alternat Med. 2018; 2018:1762478.EB

Abstract

Glucocorticoids are a risk factor for age-induced skin structure and function defects, and the glucocorticoid-activating enzyme, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), represents a promising therapeutic target. Prunella vulgaris L. (PV) is a perennial and an edible herbaceous plant normally cultivated in Asia and Europe. A recent study demonstrated a broad range of biological activities of PV including immune modulatory, antiviral, antiallergic, anti-inflammatory, antioxidant, and antidiabetic. However, little is known about the inhibitory effect of PV on 11β-HSD1. In this study, we investigated the inhibitory effect of Prunella vulgaris L. extract (PVE) and the underlying mechanism of 11β-HSD11 inhibition. Consistent with these results, cortisol levels were also reduced by PVE in vitro. The cortisone-induced translocation of glucocorticoids receptor (GR) was also attenuated. In addition, PVE inhibited a cortisone-mediated decrease in collagen content in skin. Collectively, these results suggest the beneficial effects of PVE in maintaining skin integrity.

Authors+Show Affiliations

Biospectrum Life Science Institute, Yongin 16827, Republic of Korea.Biospectrum Life Science Institute, Yongin 16827, Republic of Korea.Biospectrum Life Science Institute, Yongin 16827, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30402116

Citation

Roh, Kyung-Baeg, et al. "Inhibitory Effects of Prunella Vulgaris L. Extract On 11β-HSD1 in Human Skin Cells." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2018, 2018, p. 1762478.
Roh KB, Park D, Jung E. Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells. Evid Based Complement Alternat Med. 2018;2018:1762478.
Roh, K. B., Park, D., & Jung, E. (2018). Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells. Evidence-based Complementary and Alternative Medicine : ECAM, 2018, 1762478. https://doi.org/10.1155/2018/1762478
Roh KB, Park D, Jung E. Inhibitory Effects of Prunella Vulgaris L. Extract On 11β-HSD1 in Human Skin Cells. Evid Based Complement Alternat Med. 2018;2018:1762478. PubMed PMID: 30402116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells. AU - Roh,Kyung-Baeg, AU - Park,Deokhoon, AU - Jung,Eunsun, Y1 - 2018/10/04/ PY - 2018/02/07/received PY - 2018/06/05/revised PY - 2018/09/03/accepted PY - 2018/11/8/entrez PY - 2018/11/8/pubmed PY - 2018/11/8/medline SP - 1762478 EP - 1762478 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2018 N2 - Glucocorticoids are a risk factor for age-induced skin structure and function defects, and the glucocorticoid-activating enzyme, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), represents a promising therapeutic target. Prunella vulgaris L. (PV) is a perennial and an edible herbaceous plant normally cultivated in Asia and Europe. A recent study demonstrated a broad range of biological activities of PV including immune modulatory, antiviral, antiallergic, anti-inflammatory, antioxidant, and antidiabetic. However, little is known about the inhibitory effect of PV on 11β-HSD1. In this study, we investigated the inhibitory effect of Prunella vulgaris L. extract (PVE) and the underlying mechanism of 11β-HSD11 inhibition. Consistent with these results, cortisol levels were also reduced by PVE in vitro. The cortisone-induced translocation of glucocorticoids receptor (GR) was also attenuated. In addition, PVE inhibited a cortisone-mediated decrease in collagen content in skin. Collectively, these results suggest the beneficial effects of PVE in maintaining skin integrity. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/30402116/Inhibitory_Effects_of_Prunella_vulgaris_L__Extract_on_11β_HSD1_in_Human_Skin_Cells_ L2 - https://dx.doi.org/10.1155/2018/1762478 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.