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Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential.
Molecules. 2018 Nov 06; 23(11)M

Abstract

The proanthocyanidins from ethanol extracts (80%, v/v) of Acacia mearnsii (A. mearnsii) bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of A. mearnsii bark were found by using normal-phase HPLC. In addition, HPLC-ESI-TOF/MS and MALDI-TOF/TOF MS analyses indicated that proanthocyanidins from A. mearnsii bark exhibited with a degree of polymerization ranging from 1 to 11. These results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from A. mearnsii bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response.

Authors+Show Affiliations

Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. 13770765711@163.com.Food Bioprocessing and Nutrition Sciences Department, Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. jxiong5@ncsu.edu.Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. shuang@njfu.edu.cn.Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. xunlee@163.com.Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. yuzhang@njfu.edu.cn.College of Materials Sciences and Technology, Beijing Forestry University, Beijing 100083, China. zhanglp418@163.com.Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. hgwf@njfu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30404154

Citation

Chen, Xiao, et al. "Analytical Profiling of Proanthocyanidins From Acacia Mearnsii Bark and in Vitro Assessment of Antioxidant and Antidiabetic Potential." Molecules (Basel, Switzerland), vol. 23, no. 11, 2018.
Chen X, Xiong J, Huang S, et al. Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential. Molecules. 2018;23(11).
Chen, X., Xiong, J., Huang, S., Li, X., Zhang, Y., Zhang, L., & Wang, F. (2018). Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential. Molecules (Basel, Switzerland), 23(11). https://doi.org/10.3390/molecules23112891
Chen X, et al. Analytical Profiling of Proanthocyanidins From Acacia Mearnsii Bark and in Vitro Assessment of Antioxidant and Antidiabetic Potential. Molecules. 2018 Nov 6;23(11) PubMed PMID: 30404154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential. AU - Chen,Xiao, AU - Xiong,Jia, AU - Huang,Shenlin, AU - Li,Xun, AU - Zhang,Yu, AU - Zhang,Liping, AU - Wang,Fei, Y1 - 2018/11/06/ PY - 2018/10/16/received PY - 2018/10/31/revised PY - 2018/11/01/accepted PY - 2018/11/9/entrez PY - 2018/11/9/pubmed PY - 2019/2/5/medline KW - HPLC/MS KW - MALDI-TOF/MS KW - antidiabetic KW - antioxidant KW - degree of polymerization KW - proanthocyanidins JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 11 N2 - The proanthocyanidins from ethanol extracts (80%, v/v) of Acacia mearnsii (A. mearnsii) bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of A. mearnsii bark were found by using normal-phase HPLC. In addition, HPLC-ESI-TOF/MS and MALDI-TOF/TOF MS analyses indicated that proanthocyanidins from A. mearnsii bark exhibited with a degree of polymerization ranging from 1 to 11. These results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from A. mearnsii bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/30404154/Analytical_Profiling_of_Proanthocyanidins_from_Acacia_mearnsii_Bark_and_In_Vitro_Assessment_of_Antioxidant_and_Antidiabetic_Potential_ L2 - https://www.mdpi.com/resolver?pii=molecules23112891 DB - PRIME DP - Unbound Medicine ER -